Nano-Formulations for Pulmonary Delivery: Past, Present, and Future Perspectives
With the development of nanotechnology and confronting the problems of traditional pharmaceutical formulations in treating lung diseases, inhalable nano-formulations have attracted interest. Inhalable nano-formulations for treating lung diseases allow for precise pulmonary drug delivery, overcoming...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/16/2/161 |
| _version_ | 1797297266706350080 |
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| author | Siyuan Peng Wenhao Wang Rui Zhang Chuanbin Wu Xin Pan Zhengwei Huang |
| author_facet | Siyuan Peng Wenhao Wang Rui Zhang Chuanbin Wu Xin Pan Zhengwei Huang |
| author_sort | Siyuan Peng |
| collection | DOAJ |
| description | With the development of nanotechnology and confronting the problems of traditional pharmaceutical formulations in treating lung diseases, inhalable nano-formulations have attracted interest. Inhalable nano-formulations for treating lung diseases allow for precise pulmonary drug delivery, overcoming physiological barriers, improving aerosol lung deposition rates, and increasing drug bioavailability. They are expected to solve the difficulties faced in treating lung diseases. However, limited success has been recorded in the industrialization translation of inhalable nano-formulations. Only one relevant product has been approved by the FDA to date, suggesting that there are still many issues to be resolved in the clinical application of inhalable nano-formulations. These systems are characterized by a dependence on inhalation devices, while the adaptability of device formulation is still inconclusive, which is the most important issue impeding translational research. In this review, we categorized various inhalable nano-formulations, summarized the advantages of inhalable nano-formulations over conventional inhalation formulations, and listed the inhalable nano-formulations undergoing clinical studies. We focused on the influence of inhalation devices on nano-formulations and analyzed their adaptability. After extensive analysis of the drug delivery mechanisms, technical processes, and limitations of different inhalation devices, we concluded that vibrating mesh nebulizers might be most suitable for delivering inhalable nano-formulations, and related examples were introduced to validate our view. Finally, we presented the challenges and outlook for future development. We anticipate providing an informative reference for the field. |
| first_indexed | 2024-03-07T22:17:50Z |
| format | Article |
| id | doaj.art-599f5ec076054b61b0a52faf1802f487 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-07T22:17:50Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-599f5ec076054b61b0a52faf1802f4872024-02-23T15:30:57ZengMDPI AGPharmaceutics1999-49232024-01-0116216110.3390/pharmaceutics16020161Nano-Formulations for Pulmonary Delivery: Past, Present, and Future PerspectivesSiyuan Peng0Wenhao Wang1Rui Zhang2Chuanbin Wu3Xin Pan4Zhengwei Huang5School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510275, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510275, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510275, ChinaCollege of Pharmacy, Jinan University, Guangzhou 510632, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510275, ChinaCollege of Pharmacy, Jinan University, Guangzhou 510632, ChinaWith the development of nanotechnology and confronting the problems of traditional pharmaceutical formulations in treating lung diseases, inhalable nano-formulations have attracted interest. Inhalable nano-formulations for treating lung diseases allow for precise pulmonary drug delivery, overcoming physiological barriers, improving aerosol lung deposition rates, and increasing drug bioavailability. They are expected to solve the difficulties faced in treating lung diseases. However, limited success has been recorded in the industrialization translation of inhalable nano-formulations. Only one relevant product has been approved by the FDA to date, suggesting that there are still many issues to be resolved in the clinical application of inhalable nano-formulations. These systems are characterized by a dependence on inhalation devices, while the adaptability of device formulation is still inconclusive, which is the most important issue impeding translational research. In this review, we categorized various inhalable nano-formulations, summarized the advantages of inhalable nano-formulations over conventional inhalation formulations, and listed the inhalable nano-formulations undergoing clinical studies. We focused on the influence of inhalation devices on nano-formulations and analyzed their adaptability. After extensive analysis of the drug delivery mechanisms, technical processes, and limitations of different inhalation devices, we concluded that vibrating mesh nebulizers might be most suitable for delivering inhalable nano-formulations, and related examples were introduced to validate our view. Finally, we presented the challenges and outlook for future development. We anticipate providing an informative reference for the field.https://www.mdpi.com/1999-4923/16/2/161inhalable nano-formulationsinhalation devicesindustrializationnebulizers |
| spellingShingle | Siyuan Peng Wenhao Wang Rui Zhang Chuanbin Wu Xin Pan Zhengwei Huang Nano-Formulations for Pulmonary Delivery: Past, Present, and Future Perspectives Pharmaceutics inhalable nano-formulations inhalation devices industrialization nebulizers |
| title | Nano-Formulations for Pulmonary Delivery: Past, Present, and Future Perspectives |
| title_full | Nano-Formulations for Pulmonary Delivery: Past, Present, and Future Perspectives |
| title_fullStr | Nano-Formulations for Pulmonary Delivery: Past, Present, and Future Perspectives |
| title_full_unstemmed | Nano-Formulations for Pulmonary Delivery: Past, Present, and Future Perspectives |
| title_short | Nano-Formulations for Pulmonary Delivery: Past, Present, and Future Perspectives |
| title_sort | nano formulations for pulmonary delivery past present and future perspectives |
| topic | inhalable nano-formulations inhalation devices industrialization nebulizers |
| url | https://www.mdpi.com/1999-4923/16/2/161 |
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