Mutation S110L of H1N1 Influenza Virus Hemagglutinin: A Potent Determinant of Attenuation in the Mouse Model

Mutation S110L of H1N1 Influenza Virus Hemagglutinin: A Potent Determinant of Attenuation in the Mouse Model

Characterization of a pandemic 2009 H1N1 influenza virus isolated from a fatal case patient (F-IAV), showed the presence of three different mutations; potential determinants of its high pathogenicity that were located in the polymerase subunits (PB2 A221T and PA D529N) and the hemagglutinin (HA S110...

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Bibliographic Details
Main Authors: Amelia Nieto, Jasmina Vasilijevic, Nuno Brito Santos, Noelia Zamarreño, Pablo López, Maria Joao Amorim, Ana Falcon
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
influenza virus
HA S110L mutation
attenuation
in vivo pathogenicity
viral entry
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00132/full

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