A Systematic Review of the Biological Effects of Cordycepin
We conducted a systematic review of the literature on the effects of cordycepin on cell survival and proliferation, inflammation, signal transduction and animal models. A total of 1204 publications on cordycepin were found by the cut-off date of 1 February 2021. After application of the exclusion cr...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/19/5886 |
| _version_ | 1797515917704298496 |
|---|---|
| author | Masar Radhi Sadaf Ashraf Steven Lawrence Asta Arendt Tranholm Peter Arthur David Wellham Abdul Hafeez Ammar Sabah Khamis Robert Thomas Daniel McWilliams Cornelia Huiberdina de Moor |
| author_facet | Masar Radhi Sadaf Ashraf Steven Lawrence Asta Arendt Tranholm Peter Arthur David Wellham Abdul Hafeez Ammar Sabah Khamis Robert Thomas Daniel McWilliams Cornelia Huiberdina de Moor |
| author_sort | Masar Radhi |
| collection | DOAJ |
| description | We conducted a systematic review of the literature on the effects of cordycepin on cell survival and proliferation, inflammation, signal transduction and animal models. A total of 1204 publications on cordycepin were found by the cut-off date of 1 February 2021. After application of the exclusion criteria, 791 papers remained. These were read and data on the chosen subjects were extracted. We found 192 papers on the effects of cordycepin on cell survival and proliferation and calculated a median inhibitory concentration (IC<sub>50</sub>) of 135 µM. Cordycepin consistently repressed cell migration (26 papers) and cellular inflammation (53 papers). Evaluation of 76 papers on signal transduction indicated consistently reduced PI3K/mTOR/AKT and ERK signalling and activation of AMPK. In contrast, the effects of cordycepin on the p38 and Jun kinases were variable, as were the effects on cell cycle arrest (53 papers), suggesting these are cell-specific responses. The examination of 150 animal studies indicated that purified cordycepin has many potential therapeutic effects, including the reduction of tumour growth (37 papers), repression of pain and inflammation (9 papers), protecting brain function (11 papers), improvement of respiratory and cardiac conditions (8 and 19 papers) and amelioration of metabolic disorders (8 papers). Nearly all these data are consistent with cordycepin mediating its therapeutic effects through activating AMPK, inhibiting PI3K/mTOR/AKT and repressing the inflammatory response. We conclude that cordycepin has excellent potential as a lead for drug development, especially for age-related diseases. In addition, we discuss the remaining issues around the mechanism of action, toxicity and biodistribution of cordycepin. |
| first_indexed | 2024-03-10T06:53:59Z |
| format | Article |
| id | doaj.art-59a407acdfd042a49779ca8750d493a6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T06:53:59Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-59a407acdfd042a49779ca8750d493a62023-11-22T16:34:06ZengMDPI AGMolecules1420-30492021-09-012619588610.3390/molecules26195886A Systematic Review of the Biological Effects of CordycepinMasar Radhi0Sadaf Ashraf1Steven Lawrence2Asta Arendt Tranholm3Peter Arthur David Wellham4Abdul Hafeez5Ammar Sabah Khamis6Robert Thomas7Daniel McWilliams8Cornelia Huiberdina de Moor9Pain Centre Versus Arthritis, University of Nottingham, Nottingham NG7 2RD, UKAberdeen Centre for Arthritis and Musculoskeletal Health, Institute of Medical Sciences, Aberdeen AB25 2ZD, UKSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UKPain Centre Versus Arthritis, University of Nottingham, Nottingham NG7 2RD, UKSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UKSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UKSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UKThe Primrose Oncology Unit, Bedford Hospital NHS Trust, Bedford MK42 9DJ, UKPain Centre Versus Arthritis, University of Nottingham, Nottingham NG7 2RD, UKPain Centre Versus Arthritis, University of Nottingham, Nottingham NG7 2RD, UKWe conducted a systematic review of the literature on the effects of cordycepin on cell survival and proliferation, inflammation, signal transduction and animal models. A total of 1204 publications on cordycepin were found by the cut-off date of 1 February 2021. After application of the exclusion criteria, 791 papers remained. These were read and data on the chosen subjects were extracted. We found 192 papers on the effects of cordycepin on cell survival and proliferation and calculated a median inhibitory concentration (IC<sub>50</sub>) of 135 µM. Cordycepin consistently repressed cell migration (26 papers) and cellular inflammation (53 papers). Evaluation of 76 papers on signal transduction indicated consistently reduced PI3K/mTOR/AKT and ERK signalling and activation of AMPK. In contrast, the effects of cordycepin on the p38 and Jun kinases were variable, as were the effects on cell cycle arrest (53 papers), suggesting these are cell-specific responses. The examination of 150 animal studies indicated that purified cordycepin has many potential therapeutic effects, including the reduction of tumour growth (37 papers), repression of pain and inflammation (9 papers), protecting brain function (11 papers), improvement of respiratory and cardiac conditions (8 and 19 papers) and amelioration of metabolic disorders (8 papers). Nearly all these data are consistent with cordycepin mediating its therapeutic effects through activating AMPK, inhibiting PI3K/mTOR/AKT and repressing the inflammatory response. We conclude that cordycepin has excellent potential as a lead for drug development, especially for age-related diseases. In addition, we discuss the remaining issues around the mechanism of action, toxicity and biodistribution of cordycepin.https://www.mdpi.com/1420-3049/26/19/5886cordycepinnatural productsignal transductionAKTmTORAMPK |
| spellingShingle | Masar Radhi Sadaf Ashraf Steven Lawrence Asta Arendt Tranholm Peter Arthur David Wellham Abdul Hafeez Ammar Sabah Khamis Robert Thomas Daniel McWilliams Cornelia Huiberdina de Moor A Systematic Review of the Biological Effects of Cordycepin Molecules cordycepin natural product signal transduction AKT mTOR AMPK |
| title | A Systematic Review of the Biological Effects of Cordycepin |
| title_full | A Systematic Review of the Biological Effects of Cordycepin |
| title_fullStr | A Systematic Review of the Biological Effects of Cordycepin |
| title_full_unstemmed | A Systematic Review of the Biological Effects of Cordycepin |
| title_short | A Systematic Review of the Biological Effects of Cordycepin |
| title_sort | systematic review of the biological effects of cordycepin |
| topic | cordycepin natural product signal transduction AKT mTOR AMPK |
| url | https://www.mdpi.com/1420-3049/26/19/5886 |
| work_keys_str_mv | AT masarradhi asystematicreviewofthebiologicaleffectsofcordycepin AT sadafashraf asystematicreviewofthebiologicaleffectsofcordycepin AT stevenlawrence asystematicreviewofthebiologicaleffectsofcordycepin AT astaarendttranholm asystematicreviewofthebiologicaleffectsofcordycepin AT peterarthurdavidwellham asystematicreviewofthebiologicaleffectsofcordycepin AT abdulhafeez asystematicreviewofthebiologicaleffectsofcordycepin AT ammarsabahkhamis asystematicreviewofthebiologicaleffectsofcordycepin AT robertthomas asystematicreviewofthebiologicaleffectsofcordycepin AT danielmcwilliams asystematicreviewofthebiologicaleffectsofcordycepin AT corneliahuiberdinademoor asystematicreviewofthebiologicaleffectsofcordycepin AT masarradhi systematicreviewofthebiologicaleffectsofcordycepin AT sadafashraf systematicreviewofthebiologicaleffectsofcordycepin AT stevenlawrence systematicreviewofthebiologicaleffectsofcordycepin AT astaarendttranholm systematicreviewofthebiologicaleffectsofcordycepin AT peterarthurdavidwellham systematicreviewofthebiologicaleffectsofcordycepin AT abdulhafeez systematicreviewofthebiologicaleffectsofcordycepin AT ammarsabahkhamis systematicreviewofthebiologicaleffectsofcordycepin AT robertthomas systematicreviewofthebiologicaleffectsofcordycepin AT danielmcwilliams systematicreviewofthebiologicaleffectsofcordycepin AT corneliahuiberdinademoor systematicreviewofthebiologicaleffectsofcordycepin |