Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells
In this study, the authors demonstrated that agents targeting skeletal muscle metabolism by modulating β2-adrenergic receptor-dependent signaling may prove beneficial as novel antidiabetic drugs.
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-27540-w |
| _version_ | 1798026431383470080 |
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| author | Jaroslawna Meister Derek B. J. Bone Jonas R. Knudsen Luiz F. Barella Thomas J. Velenosi Dmitry Akhmedov Regina J. Lee Amanda H. Cohen Oksana Gavrilova Yinghong Cui Gerard Karsenty Min Chen Lee S. Weinstein Maximilian Kleinert Rebecca Berdeaux Thomas E. Jensen Erik A. Richter Jürgen Wess |
| author_facet | Jaroslawna Meister Derek B. J. Bone Jonas R. Knudsen Luiz F. Barella Thomas J. Velenosi Dmitry Akhmedov Regina J. Lee Amanda H. Cohen Oksana Gavrilova Yinghong Cui Gerard Karsenty Min Chen Lee S. Weinstein Maximilian Kleinert Rebecca Berdeaux Thomas E. Jensen Erik A. Richter Jürgen Wess |
| author_sort | Jaroslawna Meister |
| collection | DOAJ |
| description | In this study, the authors demonstrated that agents targeting skeletal muscle metabolism by modulating β2-adrenergic receptor-dependent signaling may prove beneficial as novel antidiabetic drugs. |
| first_indexed | 2024-04-11T18:35:25Z |
| format | Article |
| id | doaj.art-59a46724f573486ab78cf2fe37925d04 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T18:35:25Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-59a46724f573486ab78cf2fe37925d042022-12-22T04:09:17ZengNature PortfolioNature Communications2041-17232022-01-0113111410.1038/s41467-021-27540-wClenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cellsJaroslawna Meister0Derek B. J. Bone1Jonas R. Knudsen2Luiz F. Barella3Thomas J. Velenosi4Dmitry Akhmedov5Regina J. Lee6Amanda H. Cohen7Oksana Gavrilova8Yinghong Cui9Gerard Karsenty10Min Chen11Lee S. Weinstein12Maximilian Kleinert13Rebecca Berdeaux14Thomas E. Jensen15Erik A. Richter16Jürgen Wess17Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesDepartments of Nutrition, Exercise and Sports, University of CopenhagenMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesFaculty of Pharmaceutical Sciences, University of British ColumbiaDepartments of Integrative Biology and Pharmacology, Houston Medical SchoolMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesMouse Metabolism Core, National Institute of Diabetes and Digestive and Kidney DiseasesMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesDepartments of Genetics and Development, Vagelos College of Physicians and Surgeons, Columbia UniversityMetabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney DiseasesMetabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney DiseasesDepartments of Nutrition, Exercise and Sports, University of CopenhagenDepartments of Integrative Biology and Pharmacology, Houston Medical SchoolDepartments of Nutrition, Exercise and Sports, University of CopenhagenDepartments of Nutrition, Exercise and Sports, University of CopenhagenMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesIn this study, the authors demonstrated that agents targeting skeletal muscle metabolism by modulating β2-adrenergic receptor-dependent signaling may prove beneficial as novel antidiabetic drugs.https://doi.org/10.1038/s41467-021-27540-w |
| spellingShingle | Jaroslawna Meister Derek B. J. Bone Jonas R. Knudsen Luiz F. Barella Thomas J. Velenosi Dmitry Akhmedov Regina J. Lee Amanda H. Cohen Oksana Gavrilova Yinghong Cui Gerard Karsenty Min Chen Lee S. Weinstein Maximilian Kleinert Rebecca Berdeaux Thomas E. Jensen Erik A. Richter Jürgen Wess Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells Nature Communications |
| title | Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells |
| title_full | Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells |
| title_fullStr | Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells |
| title_full_unstemmed | Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells |
| title_short | Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells |
| title_sort | clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells |
| url | https://doi.org/10.1038/s41467-021-27540-w |
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