PLLA Composites Combined with Delivery System of Bioactive Agents for Anti-Inflammation and Re-Endothelialization
The development of a biodegradable vascular scaffold (BVS) for the treatment of cardiovascular diseases (CVDs) still requires some improvement. Among them, re-endothelialization and anti-inflammation are clinically important to restore vascular function. In this study, we proposed a coating system t...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/12/2661 |
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| author | Seung-Woon Baek Da-Seul Kim Duck Hyun Song Semi Lee Jun-Kyu Lee So-Yeon Park Jun Hyuk Kim Tae-Hyung Kim Chun Gwon Park Dong Keun Han |
| author_facet | Seung-Woon Baek Da-Seul Kim Duck Hyun Song Semi Lee Jun-Kyu Lee So-Yeon Park Jun Hyuk Kim Tae-Hyung Kim Chun Gwon Park Dong Keun Han |
| author_sort | Seung-Woon Baek |
| collection | DOAJ |
| description | The development of a biodegradable vascular scaffold (BVS) for the treatment of cardiovascular diseases (CVDs) still requires some improvement. Among them, re-endothelialization and anti-inflammation are clinically important to restore vascular function. In this study, we proposed a coating system to deliver hydrophilic bioactive agents to BVS using nanoemulsion and drop-casting methods. The poly(L-lactide) (PLLA) scaffold containing magnesium hydroxide (MH) was coated on the surface with bioactive molecules such as polydeoxyribonucleotide (PDRN), L-arginine (Arg, R), and mesenchymal stem cell-derived extracellular vesicles (EVs). PDRN upregulates the expression of VEGF as one of the A2A receptor agonists; and Arg, synthesized into nitric oxide by intracellular eNOS, induces endothelialization. In particular, EVs, which are composed of a lipid bilayer and transfer bioactive materials such as protein and nucleic acid, regulate homeostasis in blood vessels. Such a bioactive agent coating system and its PLLA composite suggest a new platform for the treatment of cardiovascular dysfunction. |
| first_indexed | 2024-03-09T15:58:20Z |
| format | Article |
| id | doaj.art-59a5e4c393bd4191b60ee2853ff2094d |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T15:58:20Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-59a5e4c393bd4191b60ee2853ff2094d2023-11-24T17:19:50ZengMDPI AGPharmaceutics1999-49232022-11-011412266110.3390/pharmaceutics14122661PLLA Composites Combined with Delivery System of Bioactive Agents for Anti-Inflammation and Re-EndothelializationSeung-Woon Baek0Da-Seul Kim1Duck Hyun Song2Semi Lee3Jun-Kyu Lee4So-Yeon Park5Jun Hyuk Kim6Tae-Hyung Kim7Chun Gwon Park8Dong Keun Han9Department of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si 13488, Republic of KoreaDepartment of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si 13488, Republic of KoreaDepartment of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si 13488, Republic of KoreaDepartment of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si 13488, Republic of KoreaDepartment of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si 13488, Republic of KoreaDepartment of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si 13488, Republic of KoreaDepartment of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si 13488, Republic of KoreaSchool of Integrative Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of KoreaDepartment of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon-si 16419, Republic of KoreaDepartment of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si 13488, Republic of KoreaThe development of a biodegradable vascular scaffold (BVS) for the treatment of cardiovascular diseases (CVDs) still requires some improvement. Among them, re-endothelialization and anti-inflammation are clinically important to restore vascular function. In this study, we proposed a coating system to deliver hydrophilic bioactive agents to BVS using nanoemulsion and drop-casting methods. The poly(L-lactide) (PLLA) scaffold containing magnesium hydroxide (MH) was coated on the surface with bioactive molecules such as polydeoxyribonucleotide (PDRN), L-arginine (Arg, R), and mesenchymal stem cell-derived extracellular vesicles (EVs). PDRN upregulates the expression of VEGF as one of the A2A receptor agonists; and Arg, synthesized into nitric oxide by intracellular eNOS, induces endothelialization. In particular, EVs, which are composed of a lipid bilayer and transfer bioactive materials such as protein and nucleic acid, regulate homeostasis in blood vessels. Such a bioactive agent coating system and its PLLA composite suggest a new platform for the treatment of cardiovascular dysfunction.https://www.mdpi.com/1999-4923/14/12/2661vascular regenerationangiogenesispoly(L-lactide)magnesium hydroxidepolydeoxyribonucleotidearginine |
| spellingShingle | Seung-Woon Baek Da-Seul Kim Duck Hyun Song Semi Lee Jun-Kyu Lee So-Yeon Park Jun Hyuk Kim Tae-Hyung Kim Chun Gwon Park Dong Keun Han PLLA Composites Combined with Delivery System of Bioactive Agents for Anti-Inflammation and Re-Endothelialization Pharmaceutics vascular regeneration angiogenesis poly(L-lactide) magnesium hydroxide polydeoxyribonucleotide arginine |
| title | PLLA Composites Combined with Delivery System of Bioactive Agents for Anti-Inflammation and Re-Endothelialization |
| title_full | PLLA Composites Combined with Delivery System of Bioactive Agents for Anti-Inflammation and Re-Endothelialization |
| title_fullStr | PLLA Composites Combined with Delivery System of Bioactive Agents for Anti-Inflammation and Re-Endothelialization |
| title_full_unstemmed | PLLA Composites Combined with Delivery System of Bioactive Agents for Anti-Inflammation and Re-Endothelialization |
| title_short | PLLA Composites Combined with Delivery System of Bioactive Agents for Anti-Inflammation and Re-Endothelialization |
| title_sort | plla composites combined with delivery system of bioactive agents for anti inflammation and re endothelialization |
| topic | vascular regeneration angiogenesis poly(L-lactide) magnesium hydroxide polydeoxyribonucleotide arginine |
| url | https://www.mdpi.com/1999-4923/14/12/2661 |
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