Personalized prostate cancer therapy based on systems analysis of the apoptosis regulatory network
Targeting the androgen receptor axis provides only temporary relief for advanced prostate cancer, which often evolves into androgen-independent disease. The wide variety of signaling mechanisms connected with the pathophysiology of androgen-independent prostate cancer poses both conceptual and pract...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-06-01
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| Series: | Asian Journal of Andrology |
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| Online Access: | http://ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=3;spage=471;epage=474;aulast=Kulik |
| _version_ | 1818433674257891328 |
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| author | George Kulik |
| author_facet | George Kulik |
| author_sort | George Kulik |
| collection | DOAJ |
| description | Targeting the androgen receptor axis provides only temporary relief for advanced prostate cancer, which often evolves into androgen-independent disease. The wide variety of signaling mechanisms connected with the pathophysiology of androgen-independent prostate cancer poses both conceptual and practical challenges for the design of efficient therapies. Analysis of apoptosis regulation in prostate cancer suggests the potential value of a systems approach that integrates information on the topology of the antiapoptotic signaling network, the signal transduction pathways that inhibit apoptosis, and the expression of proteins of the Bcl2 family. This approach could be used to identify patients most likely to respond to treatments with drugs that inhibit the signaling pathways controlling apoptosis. |
| first_indexed | 2024-12-14T16:24:51Z |
| format | Article |
| id | doaj.art-59a663ab914246649279e45c65a94c7a |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-12-14T16:24:51Z |
| publishDate | 2015-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-59a663ab914246649279e45c65a94c7a2022-12-21T22:54:42ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622015-06-0117347147410.4103/1008-682X.143749Personalized prostate cancer therapy based on systems analysis of the apoptosis regulatory networkGeorge KulikTargeting the androgen receptor axis provides only temporary relief for advanced prostate cancer, which often evolves into androgen-independent disease. The wide variety of signaling mechanisms connected with the pathophysiology of androgen-independent prostate cancer poses both conceptual and practical challenges for the design of efficient therapies. Analysis of apoptosis regulation in prostate cancer suggests the potential value of a systems approach that integrates information on the topology of the antiapoptotic signaling network, the signal transduction pathways that inhibit apoptosis, and the expression of proteins of the Bcl2 family. This approach could be used to identify patients most likely to respond to treatments with drugs that inhibit the signaling pathways controlling apoptosis.http://ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=3;spage=471;epage=474;aulast=Kulikapoptosis; prostate cancer; signal transduction |
| spellingShingle | George Kulik Personalized prostate cancer therapy based on systems analysis of the apoptosis regulatory network Asian Journal of Andrology apoptosis; prostate cancer; signal transduction |
| title | Personalized prostate cancer therapy based on systems analysis of the apoptosis regulatory network |
| title_full | Personalized prostate cancer therapy based on systems analysis of the apoptosis regulatory network |
| title_fullStr | Personalized prostate cancer therapy based on systems analysis of the apoptosis regulatory network |
| title_full_unstemmed | Personalized prostate cancer therapy based on systems analysis of the apoptosis regulatory network |
| title_short | Personalized prostate cancer therapy based on systems analysis of the apoptosis regulatory network |
| title_sort | personalized prostate cancer therapy based on systems analysis of the apoptosis regulatory network |
| topic | apoptosis; prostate cancer; signal transduction |
| url | http://ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=3;spage=471;epage=474;aulast=Kulik |
| work_keys_str_mv | AT georgekulik personalizedprostatecancertherapybasedonsystemsanalysisoftheapoptosisregulatorynetwork |