Recent progress in alginate-based carriers for ocular targeting of therapeutics
Eye is one of the susceptible organs of the human body which is associated with several internal organs including the brain. Due to the protective mechanisms of body and ocular barrier properties, the area of ocular drug delivery presents a challenge to pharmaceutical researchers. Alginate is a natu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Food Hydrocolloids for Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667025922000188 |
| _version_ | 1797985415562526720 |
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| author | Sandip Karmakar Sreejan Manna Sourav Kabiraj Sougata Jana |
| author_facet | Sandip Karmakar Sreejan Manna Sourav Kabiraj Sougata Jana |
| author_sort | Sandip Karmakar |
| collection | DOAJ |
| description | Eye is one of the susceptible organs of the human body which is associated with several internal organs including the brain. Due to the protective mechanisms of body and ocular barrier properties, the area of ocular drug delivery presents a challenge to pharmaceutical researchers. Alginate is a naturally occurring polysaccharide obtained from marine brown seaweeds and bacterial sources. According to the Food and Drug Administration, (FDA) alginate is generally recognized as safe (GRAS). It is widely used as a gelling agent and thickener in the food industries. In the field of drug delivery, alginate is extensively investigated as an excipient. In ocular targeting of therapeutics, sodium alginate offers many advantages including ion sensitive in situ gelation, non-toxic and biodegradable behaviour in combination with mucoadhesive nature of the polymer. The instant gelation ability of alginate allows it to increase the ocular residence time and enhances the ocular drug bioavailability reducing the requirement of frequent administration of drug. The abundant availability and attractive physicochemical properties of alginate has encouraged pharmaceutical scientists to explore newer strategies in ocular drug targeting. In this review, the efficacy of alginate in delivering various therapeutic agents has been discussed. |
| first_indexed | 2024-04-11T07:17:41Z |
| format | Article |
| id | doaj.art-59a6655bc72849f7b157206dd49f9974 |
| institution | Directory Open Access Journal |
| issn | 2667-0259 |
| language | English |
| last_indexed | 2024-04-11T07:17:41Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Food Hydrocolloids for Health |
| spelling | doaj.art-59a6655bc72849f7b157206dd49f99742022-12-22T04:37:52ZengElsevierFood Hydrocolloids for Health2667-02592022-12-012100071Recent progress in alginate-based carriers for ocular targeting of therapeuticsSandip Karmakar0Sreejan Manna1Sourav Kabiraj2Sougata Jana3Bengal College of Pharmaceutical Sciences and Research, Bidhannagar, Durgapur, West Bengal 713212, IndiaDepartment of Pharmaceutical Technology, Brainware University, Barasat, Kolkata, West Bengal 700125, IndiaDepartment of Pharmaceutical Technology, Brainware University, Barasat, Kolkata, West Bengal 700125, IndiaDepartment of Pharmaceutics, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol, West Bengal 713301, India; Department of Health and Family Welfare, Directorate of Health Services, Kolkata, India; Corresponding author at: Department of Pharmaceutics, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol, West Bengal 713301, India.Eye is one of the susceptible organs of the human body which is associated with several internal organs including the brain. Due to the protective mechanisms of body and ocular barrier properties, the area of ocular drug delivery presents a challenge to pharmaceutical researchers. Alginate is a naturally occurring polysaccharide obtained from marine brown seaweeds and bacterial sources. According to the Food and Drug Administration, (FDA) alginate is generally recognized as safe (GRAS). It is widely used as a gelling agent and thickener in the food industries. In the field of drug delivery, alginate is extensively investigated as an excipient. In ocular targeting of therapeutics, sodium alginate offers many advantages including ion sensitive in situ gelation, non-toxic and biodegradable behaviour in combination with mucoadhesive nature of the polymer. The instant gelation ability of alginate allows it to increase the ocular residence time and enhances the ocular drug bioavailability reducing the requirement of frequent administration of drug. The abundant availability and attractive physicochemical properties of alginate has encouraged pharmaceutical scientists to explore newer strategies in ocular drug targeting. In this review, the efficacy of alginate in delivering various therapeutic agents has been discussed.http://www.sciencedirect.com/science/article/pii/S2667025922000188AlginateOcular deliveryOphthalmic targetingGelationIn situ gels |
| spellingShingle | Sandip Karmakar Sreejan Manna Sourav Kabiraj Sougata Jana Recent progress in alginate-based carriers for ocular targeting of therapeutics Food Hydrocolloids for Health Alginate Ocular delivery Ophthalmic targeting Gelation In situ gels |
| title | Recent progress in alginate-based carriers for ocular targeting of therapeutics |
| title_full | Recent progress in alginate-based carriers for ocular targeting of therapeutics |
| title_fullStr | Recent progress in alginate-based carriers for ocular targeting of therapeutics |
| title_full_unstemmed | Recent progress in alginate-based carriers for ocular targeting of therapeutics |
| title_short | Recent progress in alginate-based carriers for ocular targeting of therapeutics |
| title_sort | recent progress in alginate based carriers for ocular targeting of therapeutics |
| topic | Alginate Ocular delivery Ophthalmic targeting Gelation In situ gels |
| url | http://www.sciencedirect.com/science/article/pii/S2667025922000188 |
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