Countermeasure and therapeutic: A(1–7) to treat acute respiratory distress syndrome due to COVID-19 infection
In the wake of the COVID-19 pandemic it has become clear that there is a need for therapies that are capable of reducing damage caused to patients from infections. Infections that induce Acute Respiratory Distress Syndrome (ARDS) are especially devastating because lung damage is so critical and diff...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2020-11-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320320972018 |
| _version_ | 1797285396445396992 |
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| author | Maira Soto Gere diZerega Kathleen E Rodgers |
| author_facet | Maira Soto Gere diZerega Kathleen E Rodgers |
| author_sort | Maira Soto |
| collection | DOAJ |
| description | In the wake of the COVID-19 pandemic it has become clear that there is a need for therapies that are capable of reducing damage caused to patients from infections. Infections that induce Acute Respiratory Distress Syndrome (ARDS) are especially devastating because lung damage is so critical and difficult to manage. Angiotensin (1–7) [A(1–7)] has already been shown to protect pulmonary health and architecture in various models of disease. There is also evidence that A(1–7) can modulate immune function and protect various organs (lung, kidney, and heart) from oxidative damage and inflammation. Here we focus on making a case for the development of novel therapies that target the protective arm of the Renin Angiotensin System (RAS). |
| first_indexed | 2024-03-07T18:02:35Z |
| format | Article |
| id | doaj.art-59a7627eba214318be3e192edf104597 |
| institution | Directory Open Access Journal |
| issn | 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T18:02:35Z |
| publishDate | 2020-11-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-59a7627eba214318be3e192edf1045972024-03-02T10:28:32ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1752-89762020-11-012110.1177/1470320320972018Countermeasure and therapeutic: A(1–7) to treat acute respiratory distress syndrome due to COVID-19 infectionMaira Soto0Gere diZerega1Kathleen E Rodgers2Department of Pharmacology, College of Medicine, Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, USAUSBiotest, San Luis Obispo, CA, USADepartment of Pharmacology, College of Medicine, Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, USAIn the wake of the COVID-19 pandemic it has become clear that there is a need for therapies that are capable of reducing damage caused to patients from infections. Infections that induce Acute Respiratory Distress Syndrome (ARDS) are especially devastating because lung damage is so critical and difficult to manage. Angiotensin (1–7) [A(1–7)] has already been shown to protect pulmonary health and architecture in various models of disease. There is also evidence that A(1–7) can modulate immune function and protect various organs (lung, kidney, and heart) from oxidative damage and inflammation. Here we focus on making a case for the development of novel therapies that target the protective arm of the Renin Angiotensin System (RAS).https://doi.org/10.1177/1470320320972018 |
| spellingShingle | Maira Soto Gere diZerega Kathleen E Rodgers Countermeasure and therapeutic: A(1–7) to treat acute respiratory distress syndrome due to COVID-19 infection Journal of the Renin-Angiotensin-Aldosterone System |
| title | Countermeasure and therapeutic: A(1–7) to treat acute respiratory distress syndrome due to COVID-19 infection |
| title_full | Countermeasure and therapeutic: A(1–7) to treat acute respiratory distress syndrome due to COVID-19 infection |
| title_fullStr | Countermeasure and therapeutic: A(1–7) to treat acute respiratory distress syndrome due to COVID-19 infection |
| title_full_unstemmed | Countermeasure and therapeutic: A(1–7) to treat acute respiratory distress syndrome due to COVID-19 infection |
| title_short | Countermeasure and therapeutic: A(1–7) to treat acute respiratory distress syndrome due to COVID-19 infection |
| title_sort | countermeasure and therapeutic a 1 7 to treat acute respiratory distress syndrome due to covid 19 infection |
| url | https://doi.org/10.1177/1470320320972018 |
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