High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma
Over the years, molecular subtypes based on estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2) status have been observed to effectively guide decision-making for the optimal treatment of patients with breast carcinoma (BRCA). However, despite thi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-01-01
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| Series: | Bioengineered |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21655979.2021.1990673 |
| _version_ | 1798033904072916992 |
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| author | Gaoda Ju Cheng Xu Kai Zeng Tianhao Zhou Lijuan Zang |
| author_facet | Gaoda Ju Cheng Xu Kai Zeng Tianhao Zhou Lijuan Zang |
| author_sort | Gaoda Ju |
| collection | DOAJ |
| description | Over the years, molecular subtypes based on estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2) status have been observed to effectively guide decision-making for the optimal treatment of patients with breast carcinoma (BRCA). However, despite this progress, there are still more than 41,000 BRCA-related fatalities each year in the United States. Moreover, effective drug targets for triple-negative breast carcinoma (TNBC) are still lacking. Given its high mortality rate, it is necessary to investigate more biomarkers with prognostic and pathological relevance in BRCA. In our study, we examined the expression patterns and prognostic implications of transmembrane P24 trafficking protein 9 (TMED9) in BRCA using multiple public cohorts and BRCA specimens collected from Shanghai General Hospital. In addition to this, in vitro experiments were also performed to evaluate the effects of TMED9 expression in BRCA cell proliferation and migration. Our results have demonstrated that a high expression of TMED9 promoted BRCA cell proliferation and migration and predicted poor prognosis in patients with BRCA. In conclusion, TMED9 is a potential prognostic indicator and a possible drug target of BRCA. |
| first_indexed | 2024-04-11T20:36:59Z |
| format | Article |
| id | doaj.art-59a7f861782b402a84825e51679dbc95 |
| institution | Directory Open Access Journal |
| issn | 2165-5979 2165-5987 |
| language | English |
| last_indexed | 2024-04-11T20:36:59Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Bioengineered |
| spelling | doaj.art-59a7f861782b402a84825e51679dbc952022-12-22T04:04:20ZengTaylor & Francis GroupBioengineered2165-59792165-59872021-01-011218965897910.1080/21655979.2021.19906731990673High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinomaGaoda Ju0Cheng Xu1Kai Zeng2Tianhao Zhou3Lijuan Zang4Peking University Cancer Hospital and InstituteShanghai General Hospital, Shanghai Jiaotong University School of MedicineThe Eighth Affiliated Hospital, Sun Yat-sen UniversityTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of CancerShanghai General Hospital, Shanghai Jiaotong University School of MedicineOver the years, molecular subtypes based on estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2) status have been observed to effectively guide decision-making for the optimal treatment of patients with breast carcinoma (BRCA). However, despite this progress, there are still more than 41,000 BRCA-related fatalities each year in the United States. Moreover, effective drug targets for triple-negative breast carcinoma (TNBC) are still lacking. Given its high mortality rate, it is necessary to investigate more biomarkers with prognostic and pathological relevance in BRCA. In our study, we examined the expression patterns and prognostic implications of transmembrane P24 trafficking protein 9 (TMED9) in BRCA using multiple public cohorts and BRCA specimens collected from Shanghai General Hospital. In addition to this, in vitro experiments were also performed to evaluate the effects of TMED9 expression in BRCA cell proliferation and migration. Our results have demonstrated that a high expression of TMED9 promoted BRCA cell proliferation and migration and predicted poor prognosis in patients with BRCA. In conclusion, TMED9 is a potential prognostic indicator and a possible drug target of BRCA.http://dx.doi.org/10.1080/21655979.2021.1990673tmed9breast carcinomabiomarkerprognosisbioinformatics |
| spellingShingle | Gaoda Ju Cheng Xu Kai Zeng Tianhao Zhou Lijuan Zang High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma Bioengineered tmed9 breast carcinoma biomarker prognosis bioinformatics |
| title | High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma |
| title_full | High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma |
| title_fullStr | High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma |
| title_full_unstemmed | High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma |
| title_short | High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma |
| title_sort | high expression of transmembrane p24 trafficking protein 9 predicts poor prognosis in breast carcinoma |
| topic | tmed9 breast carcinoma biomarker prognosis bioinformatics |
| url | http://dx.doi.org/10.1080/21655979.2021.1990673 |
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