Antibodies to Bordetella pertussis antigens in maternal and cord blood pairs: a Thai cohort study
Background Pertussis is a vaccine-preventable disease, yet an increasing incidence of pertussis occurs in many countries. Thailand has a long-standing pertussis vaccination policy, therefore most expectant mothers today had received vaccines as children. The resurgence of pertussis among Thai infant...
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PeerJ Inc.
2017-11-01
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| author | Nasamon Wanlapakorn Thanunrat Thongmee Preeyaporn Vichaiwattana Elke Leuridan Sompong Vongpunsawad Yong Poovorawan |
| author_facet | Nasamon Wanlapakorn Thanunrat Thongmee Preeyaporn Vichaiwattana Elke Leuridan Sompong Vongpunsawad Yong Poovorawan |
| author_sort | Nasamon Wanlapakorn |
| collection | DOAJ |
| description | Background Pertussis is a vaccine-preventable disease, yet an increasing incidence of pertussis occurs in many countries. Thailand has a long-standing pertussis vaccination policy, therefore most expectant mothers today had received vaccines as children. The resurgence of pertussis among Thai infants in recent years led us to examine the pre-existing antibodies to Bordetella pertussis antigens in a cohort of 90 pregnant women. Methods We evaluated the IgG to the Pertussis toxin (PT), filamentous hemagglutinin (FHA) and pertactin (PRN) in maternal and cord blood sera using commercial enzyme-linked immunosorbent assays (ELISA). Results When values of >10 IU/ml were accepted as potential protective concentrations, we found that the percentages of unprotected infants were 73.3%, 43.3% and 75.5% for anti-PT, anti-FHA and anti-PRN IgG, respectively. Discussion These results may explain the susceptibility for pertussis among newborn infants in Thailand and support the requirement for a pertussis booster vaccine during pregnancy, which may contribute to the passive seroprotection among newborns during the first months of life. |
| first_indexed | 2024-03-09T06:55:05Z |
| format | Article |
| id | doaj.art-59a83deb1b9f4bf6bcc399958e3d28f5 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:55:05Z |
| publishDate | 2017-11-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
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| spelling | doaj.art-59a83deb1b9f4bf6bcc399958e3d28f52023-12-03T10:04:08ZengPeerJ Inc.PeerJ2167-83592017-11-015e404310.7717/peerj.4043Antibodies to Bordetella pertussis antigens in maternal and cord blood pairs: a Thai cohort studyNasamon Wanlapakorn0Thanunrat Thongmee1Preeyaporn Vichaiwattana2Elke Leuridan3Sompong Vongpunsawad4Yong Poovorawan5Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandCenter of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandCenter of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandCentre for the Evaluation of Vaccination, Vaccine & Infectious Disease Institute, University of Antwerp, BelgiumCenter of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandCenter of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandBackground Pertussis is a vaccine-preventable disease, yet an increasing incidence of pertussis occurs in many countries. Thailand has a long-standing pertussis vaccination policy, therefore most expectant mothers today had received vaccines as children. The resurgence of pertussis among Thai infants in recent years led us to examine the pre-existing antibodies to Bordetella pertussis antigens in a cohort of 90 pregnant women. Methods We evaluated the IgG to the Pertussis toxin (PT), filamentous hemagglutinin (FHA) and pertactin (PRN) in maternal and cord blood sera using commercial enzyme-linked immunosorbent assays (ELISA). Results When values of >10 IU/ml were accepted as potential protective concentrations, we found that the percentages of unprotected infants were 73.3%, 43.3% and 75.5% for anti-PT, anti-FHA and anti-PRN IgG, respectively. Discussion These results may explain the susceptibility for pertussis among newborn infants in Thailand and support the requirement for a pertussis booster vaccine during pregnancy, which may contribute to the passive seroprotection among newborns during the first months of life.https://peerj.com/articles/4043.pdfPertussisPregnantThaiAntibodiesBordetella pertussis |
| spellingShingle | Nasamon Wanlapakorn Thanunrat Thongmee Preeyaporn Vichaiwattana Elke Leuridan Sompong Vongpunsawad Yong Poovorawan Antibodies to Bordetella pertussis antigens in maternal and cord blood pairs: a Thai cohort study PeerJ Pertussis Pregnant Thai Antibodies Bordetella pertussis |
| title | Antibodies to Bordetella pertussis antigens in maternal and cord blood pairs: a Thai cohort study |
| title_full | Antibodies to Bordetella pertussis antigens in maternal and cord blood pairs: a Thai cohort study |
| title_fullStr | Antibodies to Bordetella pertussis antigens in maternal and cord blood pairs: a Thai cohort study |
| title_full_unstemmed | Antibodies to Bordetella pertussis antigens in maternal and cord blood pairs: a Thai cohort study |
| title_short | Antibodies to Bordetella pertussis antigens in maternal and cord blood pairs: a Thai cohort study |
| title_sort | antibodies to bordetella pertussis antigens in maternal and cord blood pairs a thai cohort study |
| topic | Pertussis Pregnant Thai Antibodies Bordetella pertussis |
| url | https://peerj.com/articles/4043.pdf |
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