Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infection
Toxoplasmosis: Insights into immunity Researchers are extensively studying immune responses to the single-celled parasite Toxoplasma gondii, which infects around one-third of humans, often harmlessly, but can cause life-threatening toxoplasmosis infections in patients with weakened immune systems. M...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-12-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-019-0353-9 |
| _version_ | 1830089814242754560 |
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| author | Miwa Sasai Masahiro Yamamoto |
| author_facet | Miwa Sasai Masahiro Yamamoto |
| author_sort | Miwa Sasai |
| collection | DOAJ |
| description | Toxoplasmosis: Insights into immunity Researchers are extensively studying immune responses to the single-celled parasite Toxoplasma gondii, which infects around one-third of humans, often harmlessly, but can cause life-threatening toxoplasmosis infections in patients with weakened immune systems. Masahiro Yamamoto and Miwa Sasai at Osaka University in Japan review recent advances in understanding the interactions between the immune system and the parasite. They consider non-specific ‘innate’ immune responses and also the ‘acquired’ responses that target specific parts of the parasite, referred to as antigens. Methods that selectively switch off genes in mice are revealing details presumed to also be relevant for humans. Significant molecules, molecular signaling pathways and immune-regulating processes are being identified. Recent studies suggest cell-autonomous immunity, the ability of host cells to defend themselves against attack, plays a significant role in fighting Toxoplasma gondii infection. |
| first_indexed | 2024-12-16T16:52:11Z |
| format | Article |
| id | doaj.art-59aba2c0a55b4809aa65d6173f6db5ba |
| institution | Directory Open Access Journal |
| issn | 1226-3613 2092-6413 |
| language | English |
| last_indexed | 2024-12-16T16:52:11Z |
| publishDate | 2019-12-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-59aba2c0a55b4809aa65d6173f6db5ba2022-12-21T22:24:00ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132019-12-01511211010.1038/s12276-019-0353-9Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infectionMiwa Sasai0Masahiro Yamamoto1Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka UniversityDepartment of Immunoparasitology, Research Institute for Microbial Diseases, Osaka UniversityToxoplasmosis: Insights into immunity Researchers are extensively studying immune responses to the single-celled parasite Toxoplasma gondii, which infects around one-third of humans, often harmlessly, but can cause life-threatening toxoplasmosis infections in patients with weakened immune systems. Masahiro Yamamoto and Miwa Sasai at Osaka University in Japan review recent advances in understanding the interactions between the immune system and the parasite. They consider non-specific ‘innate’ immune responses and also the ‘acquired’ responses that target specific parts of the parasite, referred to as antigens. Methods that selectively switch off genes in mice are revealing details presumed to also be relevant for humans. Significant molecules, molecular signaling pathways and immune-regulating processes are being identified. Recent studies suggest cell-autonomous immunity, the ability of host cells to defend themselves against attack, plays a significant role in fighting Toxoplasma gondii infection.https://doi.org/10.1038/s12276-019-0353-9 |
| spellingShingle | Miwa Sasai Masahiro Yamamoto Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infection Experimental and Molecular Medicine |
| title | Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infection |
| title_full | Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infection |
| title_fullStr | Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infection |
| title_full_unstemmed | Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infection |
| title_short | Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infection |
| title_sort | innate adaptive and cell autonomous immunity against toxoplasma gondii infection |
| url | https://doi.org/10.1038/s12276-019-0353-9 |
| work_keys_str_mv | AT miwasasai innateadaptiveandcellautonomousimmunityagainsttoxoplasmagondiiinfection AT masahiroyamamoto innateadaptiveandcellautonomousimmunityagainsttoxoplasmagondiiinfection |