Metronidazole-induced cerebellar toxicity
Metronidazole is a very common antibacterial and antiprotozoal with wide usage across the globe, including the least developed countries. It is generally well-tolerated with a low incidence of serious side-effects. Neurological toxicity is fairly common with this drug, however majority of these are...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2016-04-01
|
| Series: | Neurology International |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/ni/article/view/6365 |
| _version_ | 1797763076186963968 |
|---|---|
| author | Amit Agarwal Sangam Kanekar Shyam Sabat Krishnamurthy Thamburaj |
| author_facet | Amit Agarwal Sangam Kanekar Shyam Sabat Krishnamurthy Thamburaj |
| author_sort | Amit Agarwal |
| collection | DOAJ |
| description | Metronidazole is a very common antibacterial and antiprotozoal with wide usage across the globe, including the least developed countries. It is generally well-tolerated with a low incidence of serious side-effects. Neurological toxicity is fairly common with this drug, however majority of these are peripheral neuropathy with very few cases of central nervous toxicity reported. We report the imaging findings in two patients with cerebellar dysfunction after Metronidazole usage. Signal changes in the dentate and red nucleus were seen on magnetic resonance imaging in these patients. Most of the cases reported in literature reported similar findings, suggesting high predilection for the dentate nucleus in metronidazole induced encephalopathy. |
| first_indexed | 2024-03-12T19:36:23Z |
| format | Article |
| id | doaj.art-59ac069e924f4d8aa9054c2800b730f2 |
| institution | Directory Open Access Journal |
| issn | 2035-8385 2035-8377 |
| language | English |
| last_indexed | 2024-03-12T19:36:23Z |
| publishDate | 2016-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj.art-59ac069e924f4d8aa9054c2800b730f22023-08-02T04:08:51ZengMDPI AGNeurology International2035-83852035-83772016-04-018110.4081/ni.2016.63653310Metronidazole-induced cerebellar toxicityAmit Agarwal0Sangam Kanekar1Shyam Sabat2Krishnamurthy Thamburaj3Department of Radiology, Penn State University, Hershey Medical Center, PADepartment of Radiology, Department of Neurology, Penn State University, Hershey Medical Center, PADepartment of Radiology, Penn State University, Hershey Medical Center, PADepartment of Radiology, Penn State University, Hershey Medical Center, PAMetronidazole is a very common antibacterial and antiprotozoal with wide usage across the globe, including the least developed countries. It is generally well-tolerated with a low incidence of serious side-effects. Neurological toxicity is fairly common with this drug, however majority of these are peripheral neuropathy with very few cases of central nervous toxicity reported. We report the imaging findings in two patients with cerebellar dysfunction after Metronidazole usage. Signal changes in the dentate and red nucleus were seen on magnetic resonance imaging in these patients. Most of the cases reported in literature reported similar findings, suggesting high predilection for the dentate nucleus in metronidazole induced encephalopathy.http://www.pagepress.org/journals/index.php/ni/article/view/6365Metronidazoledentatetoxicitymagnetic resonance imaging |
| spellingShingle | Amit Agarwal Sangam Kanekar Shyam Sabat Krishnamurthy Thamburaj Metronidazole-induced cerebellar toxicity Neurology International Metronidazole dentate toxicity magnetic resonance imaging |
| title | Metronidazole-induced cerebellar toxicity |
| title_full | Metronidazole-induced cerebellar toxicity |
| title_fullStr | Metronidazole-induced cerebellar toxicity |
| title_full_unstemmed | Metronidazole-induced cerebellar toxicity |
| title_short | Metronidazole-induced cerebellar toxicity |
| title_sort | metronidazole induced cerebellar toxicity |
| topic | Metronidazole dentate toxicity magnetic resonance imaging |
| url | http://www.pagepress.org/journals/index.php/ni/article/view/6365 |
| work_keys_str_mv | AT amitagarwal metronidazoleinducedcerebellartoxicity AT sangamkanekar metronidazoleinducedcerebellartoxicity AT shyamsabat metronidazoleinducedcerebellartoxicity AT krishnamurthythamburaj metronidazoleinducedcerebellartoxicity |