Gray matter volume alterations in patients with strabismus and amblyopia: voxel-based morphometry study
Abstract This study proposes the use of the voxel-based morphometry (VBM) technique to investigate structural alterations of the cerebral cortex in patients with strabismus and amblyopia (SA). Sixteen patients with SA and sixteen healthy controls (HCs) underwent magnetic resonance imaging. Original...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-04184-w |
| _version_ | 1819006743711055872 |
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| author | Ting Su Pei-Wen Zhu Biao Li Wen-Qing Shi Qi Lin Qing Yuan Nan Jiang Chong-Gang Pei Yi Shao |
| author_facet | Ting Su Pei-Wen Zhu Biao Li Wen-Qing Shi Qi Lin Qing Yuan Nan Jiang Chong-Gang Pei Yi Shao |
| author_sort | Ting Su |
| collection | DOAJ |
| description | Abstract This study proposes the use of the voxel-based morphometry (VBM) technique to investigate structural alterations of the cerebral cortex in patients with strabismus and amblyopia (SA). Sixteen patients with SA and sixteen healthy controls (HCs) underwent magnetic resonance imaging. Original whole brain images were analyzed using the VBM method. Pearson correlation analysis was performed to evaluate the relationship between mean gray matter volume (GMV) and clinical manifestations. Receiver operating characteristic (ROC) curve analysis was applied to classify the mean GMV values of the SA group and HCs. Compared with the HCs, GMV values in the SA group showed a significant difference in the right superior temporal gyrus, posterior and anterior lobes of the cerebellum, bilateral parahippocampal gyrus, and left anterior cingulate cortex. The mean GMV value in the right superior temporal gyrus, posterior and anterior lobes of the cerebellum, and bilateral parahippocampal gyrus were negatively correlated with the angle of strabismus. The ROC curve analysis of each cerebral region confirmed the accuracy of the area under the curve. Patients with SA have reduced GMV values in some brain regions. These findings might help to reveal the potential pathogenesis of SA and its relationship with the atrophy of specific regions of the brain. |
| first_indexed | 2024-12-21T00:13:32Z |
| format | Article |
| id | doaj.art-59b09d9e91574d02917895ee07a262d8 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-21T00:13:32Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-59b09d9e91574d02917895ee07a262d82022-12-21T19:22:18ZengNature PortfolioScientific Reports2045-23222022-01-011211910.1038/s41598-021-04184-wGray matter volume alterations in patients with strabismus and amblyopia: voxel-based morphometry studyTing Su0Pei-Wen Zhu1Biao Li2Wen-Qing Shi3Qi Lin4Qing Yuan5Nan Jiang6Chong-Gang Pei7Yi Shao8Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang UniversityDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang UniversityDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang UniversityDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang UniversityDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang UniversityFujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang UniversityDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang UniversityAbstract This study proposes the use of the voxel-based morphometry (VBM) technique to investigate structural alterations of the cerebral cortex in patients with strabismus and amblyopia (SA). Sixteen patients with SA and sixteen healthy controls (HCs) underwent magnetic resonance imaging. Original whole brain images were analyzed using the VBM method. Pearson correlation analysis was performed to evaluate the relationship between mean gray matter volume (GMV) and clinical manifestations. Receiver operating characteristic (ROC) curve analysis was applied to classify the mean GMV values of the SA group and HCs. Compared with the HCs, GMV values in the SA group showed a significant difference in the right superior temporal gyrus, posterior and anterior lobes of the cerebellum, bilateral parahippocampal gyrus, and left anterior cingulate cortex. The mean GMV value in the right superior temporal gyrus, posterior and anterior lobes of the cerebellum, and bilateral parahippocampal gyrus were negatively correlated with the angle of strabismus. The ROC curve analysis of each cerebral region confirmed the accuracy of the area under the curve. Patients with SA have reduced GMV values in some brain regions. These findings might help to reveal the potential pathogenesis of SA and its relationship with the atrophy of specific regions of the brain.https://doi.org/10.1038/s41598-021-04184-w |
| spellingShingle | Ting Su Pei-Wen Zhu Biao Li Wen-Qing Shi Qi Lin Qing Yuan Nan Jiang Chong-Gang Pei Yi Shao Gray matter volume alterations in patients with strabismus and amblyopia: voxel-based morphometry study Scientific Reports |
| title | Gray matter volume alterations in patients with strabismus and amblyopia: voxel-based morphometry study |
| title_full | Gray matter volume alterations in patients with strabismus and amblyopia: voxel-based morphometry study |
| title_fullStr | Gray matter volume alterations in patients with strabismus and amblyopia: voxel-based morphometry study |
| title_full_unstemmed | Gray matter volume alterations in patients with strabismus and amblyopia: voxel-based morphometry study |
| title_short | Gray matter volume alterations in patients with strabismus and amblyopia: voxel-based morphometry study |
| title_sort | gray matter volume alterations in patients with strabismus and amblyopia voxel based morphometry study |
| url | https://doi.org/10.1038/s41598-021-04184-w |
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