No Interaction between Polymorphisms Related to Vitamin A Metabolism and Vitamin A Intake in Relation to Colorectal Cancer in a Prospective Danish Cohort
Although vitamin A is essential for gut immune cell trafficking (paramount for the intestinal immune system), epidemiological studies on the role of vitamin A in colorectal cancer (CRC) aetiology are conflicting. By using functional polymorphisms, gene−environment (GxE) interaction analyse...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/11/6/1428 |
| _version_ | 1811280844768149504 |
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| author | Vibeke Andersen Ulrich Halekoh Torsten Bohn Anne Tjønneland Ulla Vogel Tine Iskov Kopp |
| author_facet | Vibeke Andersen Ulrich Halekoh Torsten Bohn Anne Tjønneland Ulla Vogel Tine Iskov Kopp |
| author_sort | Vibeke Andersen |
| collection | DOAJ |
| description | Although vitamin A is essential for gut immune cell trafficking (paramount for the intestinal immune system), epidemiological studies on the role of vitamin A in colorectal cancer (CRC) aetiology are conflicting. By using functional polymorphisms, gene−environment (GxE) interaction analyses may identify the biological effects (or “mechanism of action”) of environmental factors on CRC aetiology. Potential interactions between dietary or supplemental vitamin A intake and genetic variation in the vitamin A metabolic pathway genes related to risk of CRC were studied. We used a nested case-cohort design within the Danish “Diet, Cancer and Health” cohort, with prospectively collected lifestyle information from 57,053 participants, and the Cox proportional hazard models and likelihood ratio test. No statistically significant associations between the selected polymorphisms and CRC, and no statistically significant interactions between vitamin A intake and the polymorphisms were found. In conclusion, no support of an involvement of vitamin A in CRC aetiology was found. |
| first_indexed | 2024-04-13T01:22:07Z |
| format | Article |
| id | doaj.art-59b719d79d1849b1b72d5295e6d57ed5 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-04-13T01:22:07Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-59b719d79d1849b1b72d5295e6d57ed52022-12-22T03:08:43ZengMDPI AGNutrients2072-66432019-06-01116142810.3390/nu11061428nu11061428No Interaction between Polymorphisms Related to Vitamin A Metabolism and Vitamin A Intake in Relation to Colorectal Cancer in a Prospective Danish CohortVibeke Andersen0Ulrich Halekoh1Torsten Bohn2Anne Tjønneland3Ulla Vogel4Tine Iskov Kopp5Focused Research Unit for Molecular Diagnostic and Clinical Research, Institute of Regional Health Research-Center Sønderjylland, Hospital of Southern Jutland, 6200 Aabenraa, DenmarkInstitute of Public Health, Unit of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, 5000 Odense, DenmarkLuxembourg Institute of Health, Department of Population Health, 1445 Strassen, LuxembourgDanish Cancer Society Research Center, 2100 Copenhagen, DenmarkNational Research Centre for the Working Environment, 2100 Copenhagen, DenmarkDanish Cancer Society Research Center, 2100 Copenhagen, DenmarkAlthough vitamin A is essential for gut immune cell trafficking (paramount for the intestinal immune system), epidemiological studies on the role of vitamin A in colorectal cancer (CRC) aetiology are conflicting. By using functional polymorphisms, gene−environment (GxE) interaction analyses may identify the biological effects (or “mechanism of action”) of environmental factors on CRC aetiology. Potential interactions between dietary or supplemental vitamin A intake and genetic variation in the vitamin A metabolic pathway genes related to risk of CRC were studied. We used a nested case-cohort design within the Danish “Diet, Cancer and Health” cohort, with prospectively collected lifestyle information from 57,053 participants, and the Cox proportional hazard models and likelihood ratio test. No statistically significant associations between the selected polymorphisms and CRC, and no statistically significant interactions between vitamin A intake and the polymorphisms were found. In conclusion, no support of an involvement of vitamin A in CRC aetiology was found.https://www.mdpi.com/2072-6643/11/6/1428gene-environment interactiondietimmune systemcandidate genepro-vitamin A-carotenoidsVitamin AretinolWestern-style diet |
| spellingShingle | Vibeke Andersen Ulrich Halekoh Torsten Bohn Anne Tjønneland Ulla Vogel Tine Iskov Kopp No Interaction between Polymorphisms Related to Vitamin A Metabolism and Vitamin A Intake in Relation to Colorectal Cancer in a Prospective Danish Cohort Nutrients gene-environment interaction diet immune system candidate gene pro-vitamin A-carotenoids Vitamin A retinol Western-style diet |
| title | No Interaction between Polymorphisms Related to Vitamin A Metabolism and Vitamin A Intake in Relation to Colorectal Cancer in a Prospective Danish Cohort |
| title_full | No Interaction between Polymorphisms Related to Vitamin A Metabolism and Vitamin A Intake in Relation to Colorectal Cancer in a Prospective Danish Cohort |
| title_fullStr | No Interaction between Polymorphisms Related to Vitamin A Metabolism and Vitamin A Intake in Relation to Colorectal Cancer in a Prospective Danish Cohort |
| title_full_unstemmed | No Interaction between Polymorphisms Related to Vitamin A Metabolism and Vitamin A Intake in Relation to Colorectal Cancer in a Prospective Danish Cohort |
| title_short | No Interaction between Polymorphisms Related to Vitamin A Metabolism and Vitamin A Intake in Relation to Colorectal Cancer in a Prospective Danish Cohort |
| title_sort | no interaction between polymorphisms related to vitamin a metabolism and vitamin a intake in relation to colorectal cancer in a prospective danish cohort |
| topic | gene-environment interaction diet immune system candidate gene pro-vitamin A-carotenoids Vitamin A retinol Western-style diet |
| url | https://www.mdpi.com/2072-6643/11/6/1428 |
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