Correlation Between Chronic Tinnitus Distress and Symptoms of Depression: A Systematic Review
ObjectivesIn this systematic review, we aim to evaluate the evidence regarding the correlation between tinnitus distress and the severity of depressive symptoms in patients with chronic tinnitus. Also, the prevalence of clinically relevant depressive symptoms scores in patients with chronic tinnitus...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.870433/full |
| _version_ | 1818150147722313728 |
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| author | Sebastiaan M. Meijers Maaike Rademaker Maaike Rademaker Rutger L. Meijers Inge Stegeman Inge Stegeman Adriana L. Smit Adriana L. Smit |
| author_facet | Sebastiaan M. Meijers Maaike Rademaker Maaike Rademaker Rutger L. Meijers Inge Stegeman Inge Stegeman Adriana L. Smit Adriana L. Smit |
| author_sort | Sebastiaan M. Meijers |
| collection | DOAJ |
| description | ObjectivesIn this systematic review, we aim to evaluate the evidence regarding the correlation between tinnitus distress and the severity of depressive symptoms in patients with chronic tinnitus. Also, the prevalence of clinically relevant depressive symptoms scores in patients with chronic tinnitus was evaluated.MethodsWe performed a systematic review in PubMed, EMBASE, and the Cochrane library in June 2021 using the terms “depression” and “tinnitus,” and their synonyms, following PRISMA guidelines. Studies were selected on relevance and critically appraised regarding risk of bias using the Newcastle–Ottowa Quality Assessment Scale.ResultsA total of 1,912 articles were screened on title and abstract after the removal of the duplicates. Eventually, 33 (1.5%) articles were included for the final analysis. Only cross-sectional cohort studies and case–control studies with a low level of evidence and a high risk of bias due to the study design and patient selection were found. Statistically significant correlations between the experienced tinnitus distress and depressive symptoms were reported in 31 out of 33 studies. Clinically relevant depression scores had a prevalence of 4.6–41.7%.ConclusionsIn this systematic review, in which mostly cross-sectional studies were included, a statistically significant correlation was found between the experienced tinnitus distress and the reported severity of symptoms of depression in patients with chronic tinnitus. A wide range of clinically relevant depression scores were reported in included studies. Due to the high risk of bias of included studies it is not possible to provide a definite answer on the existence of this relationship. Future population-based studies are necessary to provide more clarity. |
| first_indexed | 2024-12-11T13:18:19Z |
| format | Article |
| id | doaj.art-59b742e4c4c94d6da2b4a1b404bc0aa5 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-11T13:18:19Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-59b742e4c4c94d6da2b4a1b404bc0aa52022-12-22T01:05:57ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-05-011310.3389/fneur.2022.870433870433Correlation Between Chronic Tinnitus Distress and Symptoms of Depression: A Systematic ReviewSebastiaan M. Meijers0Maaike Rademaker1Maaike Rademaker2Rutger L. Meijers3Inge Stegeman4Inge Stegeman5Adriana L. Smit6Adriana L. Smit7University Medical Center Utrecht, Utrecht, NetherlandsUniversity Medical Center Utrecht, Utrecht, NetherlandsBrain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, NetherlandsUniversity Medical Center Utrecht, Utrecht, NetherlandsBrain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, NetherlandsUniversity Medical Center Utrecht, Utrecht, NetherlandsBrain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, NetherlandsObjectivesIn this systematic review, we aim to evaluate the evidence regarding the correlation between tinnitus distress and the severity of depressive symptoms in patients with chronic tinnitus. Also, the prevalence of clinically relevant depressive symptoms scores in patients with chronic tinnitus was evaluated.MethodsWe performed a systematic review in PubMed, EMBASE, and the Cochrane library in June 2021 using the terms “depression” and “tinnitus,” and their synonyms, following PRISMA guidelines. Studies were selected on relevance and critically appraised regarding risk of bias using the Newcastle–Ottowa Quality Assessment Scale.ResultsA total of 1,912 articles were screened on title and abstract after the removal of the duplicates. Eventually, 33 (1.5%) articles were included for the final analysis. Only cross-sectional cohort studies and case–control studies with a low level of evidence and a high risk of bias due to the study design and patient selection were found. Statistically significant correlations between the experienced tinnitus distress and depressive symptoms were reported in 31 out of 33 studies. Clinically relevant depression scores had a prevalence of 4.6–41.7%.ConclusionsIn this systematic review, in which mostly cross-sectional studies were included, a statistically significant correlation was found between the experienced tinnitus distress and the reported severity of symptoms of depression in patients with chronic tinnitus. A wide range of clinically relevant depression scores were reported in included studies. Due to the high risk of bias of included studies it is not possible to provide a definite answer on the existence of this relationship. Future population-based studies are necessary to provide more clarity.https://www.frontiersin.org/articles/10.3389/fneur.2022.870433/fulltinnitusburdendepressiondepressive symptomsimpact |
| spellingShingle | Sebastiaan M. Meijers Maaike Rademaker Maaike Rademaker Rutger L. Meijers Inge Stegeman Inge Stegeman Adriana L. Smit Adriana L. Smit Correlation Between Chronic Tinnitus Distress and Symptoms of Depression: A Systematic Review Frontiers in Neurology tinnitus burden depression depressive symptoms impact |
| title | Correlation Between Chronic Tinnitus Distress and Symptoms of Depression: A Systematic Review |
| title_full | Correlation Between Chronic Tinnitus Distress and Symptoms of Depression: A Systematic Review |
| title_fullStr | Correlation Between Chronic Tinnitus Distress and Symptoms of Depression: A Systematic Review |
| title_full_unstemmed | Correlation Between Chronic Tinnitus Distress and Symptoms of Depression: A Systematic Review |
| title_short | Correlation Between Chronic Tinnitus Distress and Symptoms of Depression: A Systematic Review |
| title_sort | correlation between chronic tinnitus distress and symptoms of depression a systematic review |
| topic | tinnitus burden depression depressive symptoms impact |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.870433/full |
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