Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO-1) Inhibitors Based on Ortho-Naphthaquinone-Containing Natural Product

Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO-1) Inhibitors Based on Ortho-Naphthaquinone-Containing Natural Product

There is great interest in developing small molecules agents capable of reversing tumor immune escape to restore the body’s immune system. As an immunosuppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO-1) is considered a promising target for oncology immunotherapy. Currently, none of I...

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Bibliographic Details
Main Authors: Hongchuan Zhao, Pu Sun, Wei Guo, Yi Wang, Ao Zhang, Linghua Meng, Chunyong Ding
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
indoleamine 2,3-dioxygenase 1
immunosuppressive
natural product
ortho-naphthaquinone
molecular docking
Online Access:http://www.mdpi.com/1420-3049/24/6/1059

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