<i>Drosophila</i> as a Robust Model System for Assessing Autophagy: A Review
Autophagy is the process through which a body breaks down and recycles its own cellular components, primarily inside lysosomes. It is a cellular response to starvation and stress, which plays decisive roles in various biological processes such as senescence, apoptosis, carcinoma, and immune response...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/11/8/682 |
| _version_ | 1797583138650587136 |
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| author | Esref Demir Sam Kacew |
| author_facet | Esref Demir Sam Kacew |
| author_sort | Esref Demir |
| collection | DOAJ |
| description | Autophagy is the process through which a body breaks down and recycles its own cellular components, primarily inside lysosomes. It is a cellular response to starvation and stress, which plays decisive roles in various biological processes such as senescence, apoptosis, carcinoma, and immune response. Autophagy, which was first discovered as a survival mechanism during starvation in yeast, is now known to serve a wide range of functions in more advanced organisms. It plays a vital role in how cells respond to stress, starvation, and infection. While research on yeast has led to the identification of many key components of the autophagy process, more research into autophagy in more complex systems is still warranted. This review article focuses on the use of the fruit fly <i>Drosophila melanogaster</i> as a robust testing model in further research on autophagy. <i>Drosophila</i> provides an ideal environment for exploring autophagy in a living organism during its development. Additionally, <i>Drosophila</i> is a well-suited compact tool for genetic analysis in that it serves as an intermediate between yeast and mammals because evolution conserved the molecular machinery required for autophagy in this species. Experimental tractability of host–pathogen interactions in <i>Drosophila</i> also affords great convenience in modeling human diseases on analogous structures and tissues. |
| first_indexed | 2024-03-10T23:31:35Z |
| format | Article |
| id | doaj.art-59b9dba06d0e413a90063c34b6c1f676 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-10T23:31:35Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-59b9dba06d0e413a90063c34b6c1f6762023-11-19T03:14:33ZengMDPI AGToxics2305-63042023-08-0111868210.3390/toxics11080682<i>Drosophila</i> as a Robust Model System for Assessing Autophagy: A ReviewEsref Demir0Sam Kacew1Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USAR. Samuel McLaughllin Center for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, 1 Stewart (320), Ottawa, ON K1N 6N5, CanadaAutophagy is the process through which a body breaks down and recycles its own cellular components, primarily inside lysosomes. It is a cellular response to starvation and stress, which plays decisive roles in various biological processes such as senescence, apoptosis, carcinoma, and immune response. Autophagy, which was first discovered as a survival mechanism during starvation in yeast, is now known to serve a wide range of functions in more advanced organisms. It plays a vital role in how cells respond to stress, starvation, and infection. While research on yeast has led to the identification of many key components of the autophagy process, more research into autophagy in more complex systems is still warranted. This review article focuses on the use of the fruit fly <i>Drosophila melanogaster</i> as a robust testing model in further research on autophagy. <i>Drosophila</i> provides an ideal environment for exploring autophagy in a living organism during its development. Additionally, <i>Drosophila</i> is a well-suited compact tool for genetic analysis in that it serves as an intermediate between yeast and mammals because evolution conserved the molecular machinery required for autophagy in this species. Experimental tractability of host–pathogen interactions in <i>Drosophila</i> also affords great convenience in modeling human diseases on analogous structures and tissues.https://www.mdpi.com/2305-6304/11/8/682<i>Drosophila melanogaster</i>autophagyin vivo animal model systemAtgfat bodydevelopment |
| spellingShingle | Esref Demir Sam Kacew <i>Drosophila</i> as a Robust Model System for Assessing Autophagy: A Review Toxics <i>Drosophila melanogaster</i> autophagy in vivo animal model system Atg fat body development |
| title | <i>Drosophila</i> as a Robust Model System for Assessing Autophagy: A Review |
| title_full | <i>Drosophila</i> as a Robust Model System for Assessing Autophagy: A Review |
| title_fullStr | <i>Drosophila</i> as a Robust Model System for Assessing Autophagy: A Review |
| title_full_unstemmed | <i>Drosophila</i> as a Robust Model System for Assessing Autophagy: A Review |
| title_short | <i>Drosophila</i> as a Robust Model System for Assessing Autophagy: A Review |
| title_sort | i drosophila i as a robust model system for assessing autophagy a review |
| topic | <i>Drosophila melanogaster</i> autophagy in vivo animal model system Atg fat body development |
| url | https://www.mdpi.com/2305-6304/11/8/682 |
| work_keys_str_mv | AT esrefdemir idrosophilaiasarobustmodelsystemforassessingautophagyareview AT samkacew idrosophilaiasarobustmodelsystemforassessingautophagyareview |