Role of microRNA in oncogenesis of pituitary tumors and their practical significance
Microribonucleic acids (miRNAs) are a class of noncoding RNAs that regulate posttranscriptional gene expression. These molecules are regulators of cell proliferation, metabolism, apoptosis, and differentiation. MiRNAs are not degraded by RNAases and their concentrations can be measured in different...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2016-08-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/32116/pdf |
| _version_ | 1811204568050040832 |
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| author | A M Lapshina P M Khandaeva Zh E Belaya L Ya Rozhinskaya G A Melnichenko |
| author_facet | A M Lapshina P M Khandaeva Zh E Belaya L Ya Rozhinskaya G A Melnichenko |
| author_sort | A M Lapshina |
| collection | DOAJ |
| description | Microribonucleic acids (miRNAs) are a class of noncoding RNAs that regulate posttranscriptional gene expression. These molecules are regulators of cell proliferation, metabolism, apoptosis, and differentiation. MiRNAs are not degraded by RNAases and their concentrations can be measured in different body fluids, including serum. The expression of miRNAs varies in intact tissues and tumors, including pituitary adenomas. Pituitary tumors are encountered in 22.5% of the population and, in a number of cases, may be asymptomatic, but in case of invasion or/and hormone overproduction, their clinical presentation is severe with multiple symptoms leading to disability and even death. The mechanisms for the development and progression of pituitary tumors and the markers for remission and recurrence have not been adequately investigated. This literature review discusses the biological significance of miRNAs in pituitary tumors and the potential value of circulating miRNAs as biomarkers. |
| first_indexed | 2024-04-12T03:15:21Z |
| format | Article |
| id | doaj.art-59b9e380d98641499a702e91dbcdb3da |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-04-12T03:15:21Z |
| publishDate | 2016-08-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-59b9e380d98641499a702e91dbcdb3da2022-12-22T03:50:08Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422016-08-0188811512010.17116/terarkh2016888115-12029131Role of microRNA in oncogenesis of pituitary tumors and their practical significanceA M LapshinaP M KhandaevaZh E BelayaL Ya RozhinskayaG A MelnichenkoMicroribonucleic acids (miRNAs) are a class of noncoding RNAs that regulate posttranscriptional gene expression. These molecules are regulators of cell proliferation, metabolism, apoptosis, and differentiation. MiRNAs are not degraded by RNAases and their concentrations can be measured in different body fluids, including serum. The expression of miRNAs varies in intact tissues and tumors, including pituitary adenomas. Pituitary tumors are encountered in 22.5% of the population and, in a number of cases, may be asymptomatic, but in case of invasion or/and hormone overproduction, their clinical presentation is severe with multiple symptoms leading to disability and even death. The mechanisms for the development and progression of pituitary tumors and the markers for remission and recurrence have not been adequately investigated. This literature review discusses the biological significance of miRNAs in pituitary tumors and the potential value of circulating miRNAs as biomarkers.https://ter-arkhiv.ru/0040-3660/article/viewFile/32116/pdfmicrornaspituitary tumors |
| spellingShingle | A M Lapshina P M Khandaeva Zh E Belaya L Ya Rozhinskaya G A Melnichenko Role of microRNA in oncogenesis of pituitary tumors and their practical significance Терапевтический архив micrornas pituitary tumors |
| title | Role of microRNA in oncogenesis of pituitary tumors and their practical significance |
| title_full | Role of microRNA in oncogenesis of pituitary tumors and their practical significance |
| title_fullStr | Role of microRNA in oncogenesis of pituitary tumors and their practical significance |
| title_full_unstemmed | Role of microRNA in oncogenesis of pituitary tumors and their practical significance |
| title_short | Role of microRNA in oncogenesis of pituitary tumors and their practical significance |
| title_sort | role of microrna in oncogenesis of pituitary tumors and their practical significance |
| topic | micrornas pituitary tumors |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/32116/pdf |
| work_keys_str_mv | AT amlapshina roleofmicrornainoncogenesisofpituitarytumorsandtheirpracticalsignificance AT pmkhandaeva roleofmicrornainoncogenesisofpituitarytumorsandtheirpracticalsignificance AT zhebelaya roleofmicrornainoncogenesisofpituitarytumorsandtheirpracticalsignificance AT lyarozhinskaya roleofmicrornainoncogenesisofpituitarytumorsandtheirpracticalsignificance AT gamelnichenko roleofmicrornainoncogenesisofpituitarytumorsandtheirpracticalsignificance |