Epidemiological, clinical and pathological characteristics of gastric neoplasms in the province of Cremona: the experience of the first population-based specialized gastric cancer registry in Italy
Abstract Background The gastric cancer incidence rate differs widely across geographical areas. In Italy, in the province of Cremona the incidence is high, compared to the national situation. For this reason a specialized population-based registry was set up. Methods The collection encompasses all g...
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| Format: | Article |
| Language: | English |
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BMC
2019-03-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-019-5366-1 |
| _version_ | 1819058879801065472 |
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| author | B. M. Donida G. Tomasello M. Ghidini F. Buffoli M. Grassi W. Liguigli G. Maglietta L. Pergola M. Ratti G. Sabadini L. Toppo M. Ungari R. Passalacqua |
| author_facet | B. M. Donida G. Tomasello M. Ghidini F. Buffoli M. Grassi W. Liguigli G. Maglietta L. Pergola M. Ratti G. Sabadini L. Toppo M. Ungari R. Passalacqua |
| author_sort | B. M. Donida |
| collection | DOAJ |
| description | Abstract Background The gastric cancer incidence rate differs widely across geographical areas. In Italy, in the province of Cremona the incidence is high, compared to the national situation. For this reason a specialized population-based registry was set up. Methods The collection encompasses all gastric cancers diagnosed in the three districts of the province since January 1, 2010. The main data sources were the pathological and Hospital Discharge Records and patient clinical charts. Only diagnoses of primary gastric cancer were considered. For each case the following variables were registered: personal data, medical history and symptoms at diagnosis; imaging assessments performed, details on surgery and other treatments received; genetic background and biomolecular characteristics; social and environmental factors. Results As of November 2017, 1087 cases were collected; of which 876, diagnosed up to December 2015, were analyzed. Male/female ratio was 1.4. The European Age-standardized Incidence Rate was 41.4 for males and 28.3 for females as compared to a national average of 33.3 and 17.0 respectively. Median age at diagnosis was 73 for male and 78 for female. Helicobacter Pylori infection was present in fewer than 20% of cases. HER-2 gene was amplified in about 25% of cases. Primary tumour location was the gastro-esophageal junction or cardia in 17.5% in males and 8.3% in females. The majority of cases (58.3%) were diagnosed at an advanced stage and overall only 41.2% underwent surgery. Median overall survival was 14.8 months for men and 18.5 for women. Age standardized 5-year relative survival was 31.4% for men and 40.5% for females. Neoadjuvant treatment was performed in fewer than 10% of patients who underwent surgery, and the rate of postoperative therapy adherence was low. Discussion This study shows a high gastric cancer incidence in the province of Cremona, with a geographical spread across different districts. Moreover, a high percentage of gastric cancers were detected at an advanced stage of disease and a low rate of 5-year relative survival was registered. Based on these findings, effective preventive interventional health strategies and screening procedures need to be implemented to reduce the impact of this pathology in this geographical area. |
| first_indexed | 2024-12-21T14:02:13Z |
| format | Article |
| id | doaj.art-59badcaaf8b343d0a00fba8f0aa7a556 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-21T14:02:13Z |
| publishDate | 2019-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-59badcaaf8b343d0a00fba8f0aa7a5562022-12-21T19:01:20ZengBMCBMC Cancer1471-24072019-03-0119111110.1186/s12885-019-5366-1Epidemiological, clinical and pathological characteristics of gastric neoplasms in the province of Cremona: the experience of the first population-based specialized gastric cancer registry in ItalyB. M. Donida0G. Tomasello1M. Ghidini2F. Buffoli3M. Grassi4W. Liguigli5G. Maglietta6L. Pergola7M. Ratti8G. Sabadini9L. Toppo10M. Ungari11R. Passalacqua12ASST of Cremona, Viale Concordia 1ASST of Cremona, Viale Concordia 1ASST of Cremona, Viale Concordia 1ASST of Cremona, Viale Concordia 1ASST of Crema, Largo Ugo Dossena 2Hospital of SuzzaraUniversity Hospital of ParmaASST of Crema, Largo Ugo Dossena 2ASST of Cremona, Viale Concordia 1Istituto Figlie San Camillo of CremonaCivil Hospital of Voghera, ASST of PaviaASST of Cremona, Viale Concordia 1ASST of Cremona, Viale Concordia 1Abstract Background The gastric cancer incidence rate differs widely across geographical areas. In Italy, in the province of Cremona the incidence is high, compared to the national situation. For this reason a specialized population-based registry was set up. Methods The collection encompasses all gastric cancers diagnosed in the three districts of the province since January 1, 2010. The main data sources were the pathological and Hospital Discharge Records and patient clinical charts. Only diagnoses of primary gastric cancer were considered. For each case the following variables were registered: personal data, medical history and symptoms at diagnosis; imaging assessments performed, details on surgery and other treatments received; genetic background and biomolecular characteristics; social and environmental factors. Results As of November 2017, 1087 cases were collected; of which 876, diagnosed up to December 2015, were analyzed. Male/female ratio was 1.4. The European Age-standardized Incidence Rate was 41.4 for males and 28.3 for females as compared to a national average of 33.3 and 17.0 respectively. Median age at diagnosis was 73 for male and 78 for female. Helicobacter Pylori infection was present in fewer than 20% of cases. HER-2 gene was amplified in about 25% of cases. Primary tumour location was the gastro-esophageal junction or cardia in 17.5% in males and 8.3% in females. The majority of cases (58.3%) were diagnosed at an advanced stage and overall only 41.2% underwent surgery. Median overall survival was 14.8 months for men and 18.5 for women. Age standardized 5-year relative survival was 31.4% for men and 40.5% for females. Neoadjuvant treatment was performed in fewer than 10% of patients who underwent surgery, and the rate of postoperative therapy adherence was low. Discussion This study shows a high gastric cancer incidence in the province of Cremona, with a geographical spread across different districts. Moreover, a high percentage of gastric cancers were detected at an advanced stage of disease and a low rate of 5-year relative survival was registered. Based on these findings, effective preventive interventional health strategies and screening procedures need to be implemented to reduce the impact of this pathology in this geographical area.http://link.springer.com/article/10.1186/s12885-019-5366-1Gastric cancer incidencePopulation-based specialized registryGastric cancer survivalGastric cancer clinical characteristicsGastric cancer pathological characteristics |
| spellingShingle | B. M. Donida G. Tomasello M. Ghidini F. Buffoli M. Grassi W. Liguigli G. Maglietta L. Pergola M. Ratti G. Sabadini L. Toppo M. Ungari R. Passalacqua Epidemiological, clinical and pathological characteristics of gastric neoplasms in the province of Cremona: the experience of the first population-based specialized gastric cancer registry in Italy BMC Cancer Gastric cancer incidence Population-based specialized registry Gastric cancer survival Gastric cancer clinical characteristics Gastric cancer pathological characteristics |
| title | Epidemiological, clinical and pathological characteristics of gastric neoplasms in the province of Cremona: the experience of the first population-based specialized gastric cancer registry in Italy |
| title_full | Epidemiological, clinical and pathological characteristics of gastric neoplasms in the province of Cremona: the experience of the first population-based specialized gastric cancer registry in Italy |
| title_fullStr | Epidemiological, clinical and pathological characteristics of gastric neoplasms in the province of Cremona: the experience of the first population-based specialized gastric cancer registry in Italy |
| title_full_unstemmed | Epidemiological, clinical and pathological characteristics of gastric neoplasms in the province of Cremona: the experience of the first population-based specialized gastric cancer registry in Italy |
| title_short | Epidemiological, clinical and pathological characteristics of gastric neoplasms in the province of Cremona: the experience of the first population-based specialized gastric cancer registry in Italy |
| title_sort | epidemiological clinical and pathological characteristics of gastric neoplasms in the province of cremona the experience of the first population based specialized gastric cancer registry in italy |
| topic | Gastric cancer incidence Population-based specialized registry Gastric cancer survival Gastric cancer clinical characteristics Gastric cancer pathological characteristics |
| url | http://link.springer.com/article/10.1186/s12885-019-5366-1 |
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