T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration
In vivo, cells migrate across a diverse landscape of extracellular matrix containing gaps which present a challenge for cells to protrude across. Here, the authors show that T-Plastin strengthens protrusive actin networks to promote protrusion, extracellular matrix gap-bridging, and cell migration.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18586-3 |
| _version_ | 1818858386367709184 |
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| author | Damien Garbett Anjali Bisaria Changsong Yang Dannielle G. McCarthy Arnold Hayer W. E. Moerner Tatyana M. Svitkina Tobias Meyer |
| author_facet | Damien Garbett Anjali Bisaria Changsong Yang Dannielle G. McCarthy Arnold Hayer W. E. Moerner Tatyana M. Svitkina Tobias Meyer |
| author_sort | Damien Garbett |
| collection | DOAJ |
| description | In vivo, cells migrate across a diverse landscape of extracellular matrix containing gaps which present a challenge for cells to protrude across. Here, the authors show that T-Plastin strengthens protrusive actin networks to promote protrusion, extracellular matrix gap-bridging, and cell migration. |
| first_indexed | 2024-12-19T08:55:28Z |
| format | Article |
| id | doaj.art-59bc2c586f4e4738a09ac0f4b0640fca |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:55:28Z |
| publishDate | 2020-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-59bc2c586f4e4738a09ac0f4b0640fca2022-12-21T20:28:37ZengNature PortfolioNature Communications2041-17232020-09-0111111810.1038/s41467-020-18586-3T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migrationDamien Garbett0Anjali Bisaria1Changsong Yang2Dannielle G. McCarthy3Arnold Hayer4W. E. Moerner5Tatyana M. Svitkina6Tobias Meyer7Department of Chemical and Systems Biology, Stanford UniversityDepartment of Chemical and Systems Biology, Stanford UniversityDepartment of Biology, University of PennsylvaniaDepartment of Chemistry, Stanford UniversityDepartment of Chemical and Systems Biology, Stanford UniversityDepartment of Chemistry, Stanford UniversityDepartment of Biology, University of PennsylvaniaDepartment of Chemical and Systems Biology, Stanford UniversityIn vivo, cells migrate across a diverse landscape of extracellular matrix containing gaps which present a challenge for cells to protrude across. Here, the authors show that T-Plastin strengthens protrusive actin networks to promote protrusion, extracellular matrix gap-bridging, and cell migration.https://doi.org/10.1038/s41467-020-18586-3 |
| spellingShingle | Damien Garbett Anjali Bisaria Changsong Yang Dannielle G. McCarthy Arnold Hayer W. E. Moerner Tatyana M. Svitkina Tobias Meyer T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration Nature Communications |
| title | T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration |
| title_full | T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration |
| title_fullStr | T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration |
| title_full_unstemmed | T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration |
| title_short | T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration |
| title_sort | t plastin reinforces membrane protrusions to bridge matrix gaps during cell migration |
| url | https://doi.org/10.1038/s41467-020-18586-3 |
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