Consequences of PDGFRα+ fibroblast reduction in adult murine hearts

Consequences of PDGFRα+ fibroblast reduction in adult murine hearts

Fibroblasts produce the majority of collagen in the heart and are thought to regulate extracellular matrix (ECM) turnover. Although fibrosis accompanies many cardiac pathologies and is generally deleterious, the role of fibroblasts in maintaining the basal ECM network and in fibrosis in vivo is poor...

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Bibliographic Details
Main Authors: Jill T Kuwabara, Akitoshi Hara, Sumit Bhutada, Greg S Gojanovich, Jasmine Chen, Kanani Hokutan, Vikram Shettigar, Anson Y Lee, Lydia P DeAngelo, Jack R Heckl, Julia R Jahansooz, Dillon K Tacdol, Mark T Ziolo, Suneel S Apte, Michelle D Tallquist
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-09-01
Series:eLife
Subjects:
fibroblast
extracellular matrix
homeostasis
Online Access:https://elifesciences.org/articles/69854

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