Phosphate Metabolism and Pathophysiology in Parathyroid Disorders and Endocrine Tumors
The advent of new insights into phosphate metabolism must urge the endocrinologist to rethink the pathophysiology of widespread disorders, such as primary hyperparathyroidism, and also of rarer endocrine metabolic bone diseases, such as hypoparathyroidism and tumor-induced hypophosphatemia. These ra...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/23/12975 |
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| author | Guido Zavatta Paola Altieri Giulia Vandi Valentina Vicennati Uberto Pagotto Fabio Vescini |
| author_facet | Guido Zavatta Paola Altieri Giulia Vandi Valentina Vicennati Uberto Pagotto Fabio Vescini |
| author_sort | Guido Zavatta |
| collection | DOAJ |
| description | The advent of new insights into phosphate metabolism must urge the endocrinologist to rethink the pathophysiology of widespread disorders, such as primary hyperparathyroidism, and also of rarer endocrine metabolic bone diseases, such as hypoparathyroidism and tumor-induced hypophosphatemia. These rare diseases of mineral metabolism have been and will be a precious source of new information about phosphate and other minerals in the coming years. The parathyroid glands, the kidneys, and the intestine are the main organs affecting phosphate levels in the blood and urine. Parathyroid disorders, renal tubule defects, or phosphatonin-producing tumors might be unveiled from alterations of such a simple and inexpensive mineral as serum phosphate. This review will present all these disorders from a ‘phosphate perspective’. |
| first_indexed | 2024-03-10T04:52:13Z |
| format | Article |
| id | doaj.art-59be5a3bbce14cd1a69c9d524f79ffef |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:52:13Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-59be5a3bbce14cd1a69c9d524f79ffef2023-11-23T02:31:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122231297510.3390/ijms222312975Phosphate Metabolism and Pathophysiology in Parathyroid Disorders and Endocrine TumorsGuido Zavatta0Paola Altieri1Giulia Vandi2Valentina Vicennati3Uberto Pagotto4Fabio Vescini5Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDivision of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDivision of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDivision of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDivision of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyEndocrinology and Metabolism Unit, University Hospital Udine, 33100 Udine, ItalyThe advent of new insights into phosphate metabolism must urge the endocrinologist to rethink the pathophysiology of widespread disorders, such as primary hyperparathyroidism, and also of rarer endocrine metabolic bone diseases, such as hypoparathyroidism and tumor-induced hypophosphatemia. These rare diseases of mineral metabolism have been and will be a precious source of new information about phosphate and other minerals in the coming years. The parathyroid glands, the kidneys, and the intestine are the main organs affecting phosphate levels in the blood and urine. Parathyroid disorders, renal tubule defects, or phosphatonin-producing tumors might be unveiled from alterations of such a simple and inexpensive mineral as serum phosphate. This review will present all these disorders from a ‘phosphate perspective’.https://www.mdpi.com/1422-0067/22/23/12975parathyroid hormonehyperparathyroidismphosphatehypoparathyroidismosteomalaciaendocrine tumor |
| spellingShingle | Guido Zavatta Paola Altieri Giulia Vandi Valentina Vicennati Uberto Pagotto Fabio Vescini Phosphate Metabolism and Pathophysiology in Parathyroid Disorders and Endocrine Tumors International Journal of Molecular Sciences parathyroid hormone hyperparathyroidism phosphate hypoparathyroidism osteomalacia endocrine tumor |
| title | Phosphate Metabolism and Pathophysiology in Parathyroid Disorders and Endocrine Tumors |
| title_full | Phosphate Metabolism and Pathophysiology in Parathyroid Disorders and Endocrine Tumors |
| title_fullStr | Phosphate Metabolism and Pathophysiology in Parathyroid Disorders and Endocrine Tumors |
| title_full_unstemmed | Phosphate Metabolism and Pathophysiology in Parathyroid Disorders and Endocrine Tumors |
| title_short | Phosphate Metabolism and Pathophysiology in Parathyroid Disorders and Endocrine Tumors |
| title_sort | phosphate metabolism and pathophysiology in parathyroid disorders and endocrine tumors |
| topic | parathyroid hormone hyperparathyroidism phosphate hypoparathyroidism osteomalacia endocrine tumor |
| url | https://www.mdpi.com/1422-0067/22/23/12975 |
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