Elevated ambulatory systolic-diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart disease
Objectives: Ambulatory systolic-diastolic pressure regression index (ASDPRI) as a composite marker of cardiovascular (CV) properties is related to CV complications. However, genetic determinants of ASDPRI are not known. The aim of this study is to report the relationship between certain single nucle...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-05-01
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| Series: | Blood Pressure |
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| Online Access: | http://dx.doi.org/10.1080/08037051.2016.1273741 |
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| author | Marcin Wirtwein Olle Melander Marketa Sjőgren Michal Hoffmann Krzysztof Narkiewicz Marcin Gruchala Wojciech Sobiczewski |
| author_facet | Marcin Wirtwein Olle Melander Marketa Sjőgren Michal Hoffmann Krzysztof Narkiewicz Marcin Gruchala Wojciech Sobiczewski |
| author_sort | Marcin Wirtwein |
| collection | DOAJ |
| description | Objectives: Ambulatory systolic-diastolic pressure regression index (ASDPRI) as a composite marker of cardiovascular (CV) properties is related to CV complications. However, genetic determinants of ASDPRI are not known. The aim of this study is to report the relationship between certain single nucleotide polymorphisms (SNP) and ASDPRI in hypertensive patients with CAD confirmed by coronary angiography. Methods: A total of 1345 hypertensive subjects with CAD were included. SNPs were selected from genome-wide association studies. SNPs were reported to be associated with coronary artery disease risk. There were significant differences in 24 h and daytime and nighttime ASDPRIs for PHCTR1, LPA and ADAMTS7 polymorphisms. Genetic risk score (GRS18) was constructed to evaluate additive effect of 18 SNPs for ASDPRI. Results: Analysis of covariance revealed a significant relationship between the PPAB2B (β − 0.85; 95 CI −1.85–−0.16, p < 0.02), WDR12 (β − 1.31; 95 CI −2.19–−0.43, p < 0.01) polymorphisms and nighttime ASDPRI dipping. Analysis of covariance revealed a significant relationship between GRS 18 and 24-h ASDPRI (β 0.34; 95 CI 0.16–0.31, p < 0.01). Conclusions: In conclusion, ADAMTS7 and LPA polymorphisms are related to 24-h ASDPRI but PPAB2B and WDR12 gene polymorphisms are associated with nighttime ASDPRI dipping. A total of 24-h ASDPRI is determined by GRS18. |
| first_indexed | 2024-03-12T00:40:13Z |
| format | Article |
| id | doaj.art-59be7fcc264747d28b9c215d7d527077 |
| institution | Directory Open Access Journal |
| issn | 0803-7051 1651-1999 |
| language | English |
| last_indexed | 2024-03-12T00:40:13Z |
| publishDate | 2017-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Blood Pressure |
| spelling | doaj.art-59be7fcc264747d28b9c215d7d5270772023-09-15T08:45:21ZengTaylor & Francis GroupBlood Pressure0803-70511651-19992017-05-0126317418010.1080/08037051.2016.12737411273741Elevated ambulatory systolic-diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart diseaseMarcin Wirtwein0Olle Melander1Marketa Sjőgren2Michal Hoffmann3Krzysztof Narkiewicz4Marcin Gruchala5Wojciech Sobiczewski6Medical University of GdanskLund UniversityLund UniversityMedical University of GdanskMedical University of GdanskMedical University of GdanskMedical University of GdanskObjectives: Ambulatory systolic-diastolic pressure regression index (ASDPRI) as a composite marker of cardiovascular (CV) properties is related to CV complications. However, genetic determinants of ASDPRI are not known. The aim of this study is to report the relationship between certain single nucleotide polymorphisms (SNP) and ASDPRI in hypertensive patients with CAD confirmed by coronary angiography. Methods: A total of 1345 hypertensive subjects with CAD were included. SNPs were selected from genome-wide association studies. SNPs were reported to be associated with coronary artery disease risk. There were significant differences in 24 h and daytime and nighttime ASDPRIs for PHCTR1, LPA and ADAMTS7 polymorphisms. Genetic risk score (GRS18) was constructed to evaluate additive effect of 18 SNPs for ASDPRI. Results: Analysis of covariance revealed a significant relationship between the PPAB2B (β − 0.85; 95 CI −1.85–−0.16, p < 0.02), WDR12 (β − 1.31; 95 CI −2.19–−0.43, p < 0.01) polymorphisms and nighttime ASDPRI dipping. Analysis of covariance revealed a significant relationship between GRS 18 and 24-h ASDPRI (β 0.34; 95 CI 0.16–0.31, p < 0.01). Conclusions: In conclusion, ADAMTS7 and LPA polymorphisms are related to 24-h ASDPRI but PPAB2B and WDR12 gene polymorphisms are associated with nighttime ASDPRI dipping. A total of 24-h ASDPRI is determined by GRS18.http://dx.doi.org/10.1080/08037051.2016.1273741dna polymorphismcoronary artery diseasehypertensiondipping |
| spellingShingle | Marcin Wirtwein Olle Melander Marketa Sjőgren Michal Hoffmann Krzysztof Narkiewicz Marcin Gruchala Wojciech Sobiczewski Elevated ambulatory systolic-diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart disease Blood Pressure dna polymorphism coronary artery disease hypertension dipping |
| title | Elevated ambulatory systolic-diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart disease |
| title_full | Elevated ambulatory systolic-diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart disease |
| title_fullStr | Elevated ambulatory systolic-diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart disease |
| title_full_unstemmed | Elevated ambulatory systolic-diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart disease |
| title_short | Elevated ambulatory systolic-diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart disease |
| title_sort | elevated ambulatory systolic diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart disease |
| topic | dna polymorphism coronary artery disease hypertension dipping |
| url | http://dx.doi.org/10.1080/08037051.2016.1273741 |
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