Sustained Release of Antibacterial Agents from Doped Halloysite Nanotubes
The use of nanomaterials for improving drug delivery methods has been shown to be advantageous technically and viable economically. This study employed the use of halloysite nanotubes (HNTs) as nanocontainers, as well as enhancers of structural integrity in electrospun poly-e-caprolactone (PCL) scaf...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-12-01
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| Series: | Bioengineering |
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| Online Access: | http://www.mdpi.com/2306-5354/3/1/1 |
| _version_ | 1797761235755728896 |
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| author | Shraddha Patel Uday Jammalamadaka Lin Sun Karthik Tappa David K. Mills |
| author_facet | Shraddha Patel Uday Jammalamadaka Lin Sun Karthik Tappa David K. Mills |
| author_sort | Shraddha Patel |
| collection | DOAJ |
| description | The use of nanomaterials for improving drug delivery methods has been shown to be advantageous technically and viable economically. This study employed the use of halloysite nanotubes (HNTs) as nanocontainers, as well as enhancers of structural integrity in electrospun poly-e-caprolactone (PCL) scaffolds. HNTs were loaded with amoxicillin, Brilliant Green, chlorhexidine, doxycycline, gentamicin sulfate, iodine, and potassium calvulanate and release profiles assessed. Selected doped halloysite nanotubes (containing either Brilliant Green, amoxicillin and potassium calvulanate) were then mixed with poly-e-caprolactone (PLC) using the electrospinning method and woven into random and oriented-fibered nanocomposite mats. The rate of drug release from HNTs, HNTs/PCL nanocomposites, and their effect on inhibiting bacterial growth was investigated. Release profiles from nanocomposite mats showed a pattern of sustained release for all bacterial agents. Nanocomposites were able to inhibit bacterial growth for up to one-month with only a slight decrease in bacterial growth inhibition. We propose that halloysite doped nanotubes have the potential for use in a variety of medical applications including sutures and surgical dressings, without compromising material properties. |
| first_indexed | 2024-03-12T19:10:02Z |
| format | Article |
| id | doaj.art-59be851afb3946a3bffd53fa0fb8d487 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-12T19:10:02Z |
| publishDate | 2015-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-59be851afb3946a3bffd53fa0fb8d4872023-08-02T05:59:18ZengMDPI AGBioengineering2306-53542015-12-0131110.3390/bioengineering3010001bioengineering3010001Sustained Release of Antibacterial Agents from Doped Halloysite NanotubesShraddha Patel0Uday Jammalamadaka1Lin Sun2Karthik Tappa3David K. Mills4Center for Biomedical Engineering and Rehabilitation Science, Louisiana Tech University, Ruston, LA 71272, USACenter for Biomedical Engineering and Rehabilitation Science, Louisiana Tech University, Ruston, LA 71272, USACenter for Biomedical Engineering and Rehabilitation Science, Louisiana Tech University, Ruston, LA 71272, USACenter for Biomedical Engineering and Rehabilitation Science, Louisiana Tech University, Ruston, LA 71272, USACenter for Biomedical Engineering and Rehabilitation Science, Louisiana Tech University, Ruston, LA 71272, USAThe use of nanomaterials for improving drug delivery methods has been shown to be advantageous technically and viable economically. This study employed the use of halloysite nanotubes (HNTs) as nanocontainers, as well as enhancers of structural integrity in electrospun poly-e-caprolactone (PCL) scaffolds. HNTs were loaded with amoxicillin, Brilliant Green, chlorhexidine, doxycycline, gentamicin sulfate, iodine, and potassium calvulanate and release profiles assessed. Selected doped halloysite nanotubes (containing either Brilliant Green, amoxicillin and potassium calvulanate) were then mixed with poly-e-caprolactone (PLC) using the electrospinning method and woven into random and oriented-fibered nanocomposite mats. The rate of drug release from HNTs, HNTs/PCL nanocomposites, and their effect on inhibiting bacterial growth was investigated. Release profiles from nanocomposite mats showed a pattern of sustained release for all bacterial agents. Nanocomposites were able to inhibit bacterial growth for up to one-month with only a slight decrease in bacterial growth inhibition. We propose that halloysite doped nanotubes have the potential for use in a variety of medical applications including sutures and surgical dressings, without compromising material properties.http://www.mdpi.com/2306-5354/3/1/1antisepticsantibioticsdrug releasehalloysite nanotubesnanocontainerspoly-e-caprolactonenanocomposite mats |
| spellingShingle | Shraddha Patel Uday Jammalamadaka Lin Sun Karthik Tappa David K. Mills Sustained Release of Antibacterial Agents from Doped Halloysite Nanotubes Bioengineering antiseptics antibiotics drug release halloysite nanotubes nanocontainers poly-e-caprolactone nanocomposite mats |
| title | Sustained Release of Antibacterial Agents from Doped Halloysite Nanotubes |
| title_full | Sustained Release of Antibacterial Agents from Doped Halloysite Nanotubes |
| title_fullStr | Sustained Release of Antibacterial Agents from Doped Halloysite Nanotubes |
| title_full_unstemmed | Sustained Release of Antibacterial Agents from Doped Halloysite Nanotubes |
| title_short | Sustained Release of Antibacterial Agents from Doped Halloysite Nanotubes |
| title_sort | sustained release of antibacterial agents from doped halloysite nanotubes |
| topic | antiseptics antibiotics drug release halloysite nanotubes nanocontainers poly-e-caprolactone nanocomposite mats |
| url | http://www.mdpi.com/2306-5354/3/1/1 |
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