Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry
This review presents the up to date development of fused thiopyranothiazoles that comprise one of the thiazolidine derivatives classes. Thiazolidine and thiazolidinone-related compounds belong to the widely studied heterocycles from a medicinal chemistry perspective. From the chemical point of view,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-06-01
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| Series: | Scientia Pharmaceutica |
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| Online Access: | http://www.mdpi.com/2218-0532/86/2/26 |
| _version_ | 1797999542106324992 |
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| author | Anna Kryshchyshyn Olexandra Roman Andrii Lozynskyi Roman Lesyk |
| author_facet | Anna Kryshchyshyn Olexandra Roman Andrii Lozynskyi Roman Lesyk |
| author_sort | Anna Kryshchyshyn |
| collection | DOAJ |
| description | This review presents the up to date development of fused thiopyranothiazoles that comprise one of the thiazolidine derivatives classes. Thiazolidine and thiazolidinone-related compounds belong to the widely studied heterocycles from a medicinal chemistry perspective. From the chemical point of view, they are perfect heterodienes to undergo hetero-Diels–Alder reaction with a variety of dienophiles, yielding regio- and diastereoselectively thiopyranothiazole scaffolds. The annealing of thiazole and thiopyran cycles in condensed heterosystem is a precondition for the “centers conservative” creation of the ligand-target binding complex and can promote a potential selectivity to biotargets. The review covers possible therapeutic applications of thiopyrano[2,3-d]thiazoles, such as anti-inflammatory, antibacterial, anticancer as well as aniparasitic activities. Thus, thiopyrano[2,3-d]thiazoles may be used as powerful tools in the development of biologically active agents and drug-like molecules. |
| first_indexed | 2024-04-11T11:06:19Z |
| format | Article |
| id | doaj.art-59c03c19f92847c5a1eb7aed68fdebab |
| institution | Directory Open Access Journal |
| issn | 2218-0532 |
| language | English |
| last_indexed | 2024-04-11T11:06:19Z |
| publishDate | 2018-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Scientia Pharmaceutica |
| spelling | doaj.art-59c03c19f92847c5a1eb7aed68fdebab2022-12-22T04:28:17ZengMDPI AGScientia Pharmaceutica2218-05322018-06-018622610.3390/scipharm86020026scipharm86020026Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal ChemistryAnna Kryshchyshyn0Olexandra Roman1Andrii Lozynskyi2Roman Lesyk3Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, UkraineDepartment of General, Inorganic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, UkraineDepartment of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, UkraineDepartment of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, UkraineThis review presents the up to date development of fused thiopyranothiazoles that comprise one of the thiazolidine derivatives classes. Thiazolidine and thiazolidinone-related compounds belong to the widely studied heterocycles from a medicinal chemistry perspective. From the chemical point of view, they are perfect heterodienes to undergo hetero-Diels–Alder reaction with a variety of dienophiles, yielding regio- and diastereoselectively thiopyranothiazole scaffolds. The annealing of thiazole and thiopyran cycles in condensed heterosystem is a precondition for the “centers conservative” creation of the ligand-target binding complex and can promote a potential selectivity to biotargets. The review covers possible therapeutic applications of thiopyrano[2,3-d]thiazoles, such as anti-inflammatory, antibacterial, anticancer as well as aniparasitic activities. Thus, thiopyrano[2,3-d]thiazoles may be used as powerful tools in the development of biologically active agents and drug-like molecules.http://www.mdpi.com/2218-0532/86/2/264-thiazolidinonesthiopyrano[2,3-d]thiazoles[4+2]-cycloadditionbiological activity |
| spellingShingle | Anna Kryshchyshyn Olexandra Roman Andrii Lozynskyi Roman Lesyk Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry Scientia Pharmaceutica 4-thiazolidinones thiopyrano[2,3-d]thiazoles [4+2]-cycloaddition biological activity |
| title | Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry |
| title_full | Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry |
| title_fullStr | Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry |
| title_full_unstemmed | Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry |
| title_short | Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry |
| title_sort | thiopyrano 2 3 d thiazoles as new efficient scaffolds in medicinal chemistry |
| topic | 4-thiazolidinones thiopyrano[2,3-d]thiazoles [4+2]-cycloaddition biological activity |
| url | http://www.mdpi.com/2218-0532/86/2/26 |
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