A Single Point Mutation, Asn<sub>16</sub>→Lys, Dictates the Temperature-Sensitivity of the Reovirus tsG453 Mutant

A Single Point Mutation, Asn<sub>16</sub>→Lys, Dictates the Temperature-Sensitivity of the Reovirus tsG453 Mutant

Studies of conditionally lethal mutants can help delineate the structure-function relationships of biomolecules. Temperature-sensitive (<i>ts</i>) mammalian reovirus (MRV) mutants were isolated and characterized many years ago. Two of the most well-defined MRV <i>ts</i> mutan...

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Bibliographic Details
Main Authors: Kathleen K. M. Glover, Danica M. Sutherland, Terence S. Dermody, Kevin M. Coombs
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Viruses
Subjects:
reovirus reverse genetics
temperature-sensitive reovirus
site-directed mutagenesis
outer-capsid protein σ3
Online Access:https://www.mdpi.com/1999-4915/13/2/289

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