Development and validation of a chemotherapy tolerance prediction model for Chinese multiple myeloma patients: The TM frailty score
ObjectiveThe physical fitness of older individuals is heterogeneous, making it difficult to know their chemotherapy tolerance. The toxicities may offset the benefits of anti-myeloma therapy in frail patients. The accurate evaluation of frailty status before chemotherapy is essential. We aimed to exp...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1103687/full |
| _version_ | 1797946979631759360 |
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| author | Yadong Chen Jingli Gu Beihui Huang Junru Liu Xiaozhe Li Juan Li |
| author_facet | Yadong Chen Jingli Gu Beihui Huang Junru Liu Xiaozhe Li Juan Li |
| author_sort | Yadong Chen |
| collection | DOAJ |
| description | ObjectiveThe physical fitness of older individuals is heterogeneous, making it difficult to know their chemotherapy tolerance. The toxicities may offset the benefits of anti-myeloma therapy in frail patients. The accurate evaluation of frailty status before chemotherapy is essential. We aimed to explore the applicability of the IMWG GA and develop a new frailty screening tool more suitable for Chinese MM patients.Cases and methodsWe performed the IMWG GA and the full CGA in 167 MM patients and validated the applicability of the IMWG GA to chemotherapy and prognosis. The CGA domains were screened for their predictive value to improve IMWG GA and develop new frailty screening tools.ResultsThe results showed that the IMWG GA had limitations in distinguishing the risk of grade ≥3 adverse events (AEs) between fit and int-fit patients. Of the CGA domains, TUG and MNA-SF were independent prognostic factors for grade ≥3 AEs and OS and further stratified the risk of grade ≥3 AEs in the IMWG GA int-fit subgroup (P< 0.05). We combined TUG and MNA-SF to construct the TM frailty score. The frail subgroup had a higher proportion of adverse outcomes, a higher hazard ratio (HR) in Cox regression and a higher Harrell’s C-index for distinguishing the risk of grade ≥3 AEs and OS than the IMWG GA frail subgroup.ConclusionThe TM frailty score is more suitable than the IMWG GA for evaluating chemotherapy tolerance and prognosis in the Chinese population. |
| first_indexed | 2024-04-10T21:20:37Z |
| format | Article |
| id | doaj.art-59c1d40ef9454d92ba92bd3ab41c52c2 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T21:20:37Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-59c1d40ef9454d92ba92bd3ab41c52c22023-01-20T05:56:39ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-01-011310.3389/fonc.2023.11036871103687Development and validation of a chemotherapy tolerance prediction model for Chinese multiple myeloma patients: The TM frailty scoreYadong ChenJingli GuBeihui HuangJunru LiuXiaozhe LiJuan LiObjectiveThe physical fitness of older individuals is heterogeneous, making it difficult to know their chemotherapy tolerance. The toxicities may offset the benefits of anti-myeloma therapy in frail patients. The accurate evaluation of frailty status before chemotherapy is essential. We aimed to explore the applicability of the IMWG GA and develop a new frailty screening tool more suitable for Chinese MM patients.Cases and methodsWe performed the IMWG GA and the full CGA in 167 MM patients and validated the applicability of the IMWG GA to chemotherapy and prognosis. The CGA domains were screened for their predictive value to improve IMWG GA and develop new frailty screening tools.ResultsThe results showed that the IMWG GA had limitations in distinguishing the risk of grade ≥3 adverse events (AEs) between fit and int-fit patients. Of the CGA domains, TUG and MNA-SF were independent prognostic factors for grade ≥3 AEs and OS and further stratified the risk of grade ≥3 AEs in the IMWG GA int-fit subgroup (P< 0.05). We combined TUG and MNA-SF to construct the TM frailty score. The frail subgroup had a higher proportion of adverse outcomes, a higher hazard ratio (HR) in Cox regression and a higher Harrell’s C-index for distinguishing the risk of grade ≥3 AEs and OS than the IMWG GA frail subgroup.ConclusionThe TM frailty score is more suitable than the IMWG GA for evaluating chemotherapy tolerance and prognosis in the Chinese population.https://www.frontiersin.org/articles/10.3389/fonc.2023.1103687/fullmultiple myelomafrailtycomprehensive geriatric assessment (CGA)timed up and go testMNA-SF |
| spellingShingle | Yadong Chen Jingli Gu Beihui Huang Junru Liu Xiaozhe Li Juan Li Development and validation of a chemotherapy tolerance prediction model for Chinese multiple myeloma patients: The TM frailty score Frontiers in Oncology multiple myeloma frailty comprehensive geriatric assessment (CGA) timed up and go test MNA-SF |
| title | Development and validation of a chemotherapy tolerance prediction model for Chinese multiple myeloma patients: The TM frailty score |
| title_full | Development and validation of a chemotherapy tolerance prediction model for Chinese multiple myeloma patients: The TM frailty score |
| title_fullStr | Development and validation of a chemotherapy tolerance prediction model for Chinese multiple myeloma patients: The TM frailty score |
| title_full_unstemmed | Development and validation of a chemotherapy tolerance prediction model for Chinese multiple myeloma patients: The TM frailty score |
| title_short | Development and validation of a chemotherapy tolerance prediction model for Chinese multiple myeloma patients: The TM frailty score |
| title_sort | development and validation of a chemotherapy tolerance prediction model for chinese multiple myeloma patients the tm frailty score |
| topic | multiple myeloma frailty comprehensive geriatric assessment (CGA) timed up and go test MNA-SF |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1103687/full |
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