Increment of body mass index is positively correlated with worsening of endothelium-dependent and independent changes in forearm blood flow
Obesity is associated with the impairment of endothelial function leading to the initiation of the atherosclerotic process. We have hypothesized that an increasing impairment of endothelial and vascular smooth muscle cell functions occurs from lean subjects to severe obese ones. Thus, the present st...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-08-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00223/full |
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| author | Luiz Guilherme Kraemer-Aguiar Luiz Guilherme Kraemer-Aguiar Marcos Lopes De Miranda Marcos Lopes De Miranda Daniel Alexandre Bottino Ronald Albuquerque Lima Maria das Graças Coelho Souza Michelle Moura Balarini Nivaldo Ribeiro Villela Nivaldo Ribeiro Villela Eliete eBouskela |
| author_facet | Luiz Guilherme Kraemer-Aguiar Luiz Guilherme Kraemer-Aguiar Marcos Lopes De Miranda Marcos Lopes De Miranda Daniel Alexandre Bottino Ronald Albuquerque Lima Maria das Graças Coelho Souza Michelle Moura Balarini Nivaldo Ribeiro Villela Nivaldo Ribeiro Villela Eliete eBouskela |
| author_sort | Luiz Guilherme Kraemer-Aguiar |
| collection | DOAJ |
| description | Obesity is associated with the impairment of endothelial function leading to the initiation of the atherosclerotic process. We have hypothesized that an increasing impairment of endothelial and vascular smooth muscle cell functions occurs from lean subjects to severe obese ones. Thus, the present study was carried out to investigate the grade of obesity in which endothelial dysfunction can be detected and if there is an increasing impairment of endothelial and vascular smooth muscle cell functions as body mass index increases. According to body mass index, subjects were allocated into five groups: Lean controls, Overweight, Obese class I, Obese class II, and Obese class III. Endothelial and vascular smooth muscle cell functions were evaluated measuring forearm blood flow responses to increasing intra-arterial infusions of acetylcholine and sodium nitroprusside using venous occlusion plethysmography. We observed that forearm blood flow was progressively impaired from lean controls to severe obese and found no significant differences between Lean controls and Overweight groups. Our data suggests that obesity class I is the first grade of obesity in which endothelial dysfunction can be detected and that body mass index positively correlates with the worsening of endothelium-dependent and independent changes in forearm blood flow. |
| first_indexed | 2024-12-12T10:17:50Z |
| format | Article |
| id | doaj.art-59c27008e73f4ba2b83a9cee5bfa2b1e |
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| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-12T10:17:50Z |
| publishDate | 2015-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-59c27008e73f4ba2b83a9cee5bfa2b1e2022-12-22T00:27:37ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2015-08-01610.3389/fphys.2015.00223157014Increment of body mass index is positively correlated with worsening of endothelium-dependent and independent changes in forearm blood flowLuiz Guilherme Kraemer-Aguiar0Luiz Guilherme Kraemer-Aguiar1Marcos Lopes De Miranda2Marcos Lopes De Miranda3Daniel Alexandre Bottino4Ronald Albuquerque Lima5Maria das Graças Coelho Souza6Michelle Moura Balarini7Nivaldo Ribeiro Villela8Nivaldo Ribeiro Villela9Eliete eBouskela10Faculty of Medical Sciences, Rio de Janeiro State UniversityRio de Janeiro State UniversityFaculty of Medical Sciences, Rio de Janeiro State UniversityRio de Janeiro State UniversityRio de Janeiro State UniversityNational Cancer InstituteRio de Janeiro State UniversityAndarai Federal HospitalFaculty of Medical Sciences, Rio de Janeiro State UniversityRio de Janeiro State UniversityRio de Janeiro State UniversityObesity is associated with the impairment of endothelial function leading to the initiation of the atherosclerotic process. We have hypothesized that an increasing impairment of endothelial and vascular smooth muscle cell functions occurs from lean subjects to severe obese ones. Thus, the present study was carried out to investigate the grade of obesity in which endothelial dysfunction can be detected and if there is an increasing impairment of endothelial and vascular smooth muscle cell functions as body mass index increases. According to body mass index, subjects were allocated into five groups: Lean controls, Overweight, Obese class I, Obese class II, and Obese class III. Endothelial and vascular smooth muscle cell functions were evaluated measuring forearm blood flow responses to increasing intra-arterial infusions of acetylcholine and sodium nitroprusside using venous occlusion plethysmography. We observed that forearm blood flow was progressively impaired from lean controls to severe obese and found no significant differences between Lean controls and Overweight groups. Our data suggests that obesity class I is the first grade of obesity in which endothelial dysfunction can be detected and that body mass index positively correlates with the worsening of endothelium-dependent and independent changes in forearm blood flow.http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00223/fullObesityOverweightEndothelial Functionvascular reactivityForearm Blood Flowvenous occlusion plethysmography |
| spellingShingle | Luiz Guilherme Kraemer-Aguiar Luiz Guilherme Kraemer-Aguiar Marcos Lopes De Miranda Marcos Lopes De Miranda Daniel Alexandre Bottino Ronald Albuquerque Lima Maria das Graças Coelho Souza Michelle Moura Balarini Nivaldo Ribeiro Villela Nivaldo Ribeiro Villela Eliete eBouskela Increment of body mass index is positively correlated with worsening of endothelium-dependent and independent changes in forearm blood flow Frontiers in Physiology Obesity Overweight Endothelial Function vascular reactivity Forearm Blood Flow venous occlusion plethysmography |
| title | Increment of body mass index is positively correlated with worsening of endothelium-dependent and independent changes in forearm blood flow |
| title_full | Increment of body mass index is positively correlated with worsening of endothelium-dependent and independent changes in forearm blood flow |
| title_fullStr | Increment of body mass index is positively correlated with worsening of endothelium-dependent and independent changes in forearm blood flow |
| title_full_unstemmed | Increment of body mass index is positively correlated with worsening of endothelium-dependent and independent changes in forearm blood flow |
| title_short | Increment of body mass index is positively correlated with worsening of endothelium-dependent and independent changes in forearm blood flow |
| title_sort | increment of body mass index is positively correlated with worsening of endothelium dependent and independent changes in forearm blood flow |
| topic | Obesity Overweight Endothelial Function vascular reactivity Forearm Blood Flow venous occlusion plethysmography |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00223/full |
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