Chronic obstructive pulmonary disease and the hallmarks of aging
Aging is characterized by progressive deterioration of physiological integrity, decline in homeostasis, and degeneration of the tissues that occurs after the reproductive phase of life is complete, leading to impaired function. This deterioration is an important risk factor for chronic lung patholog...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Lung India |
| Subjects: | |
| Online Access: | http://www.lungindia.com/article.asp?issn=0970-2113;year=2018;volume=35;issue=4;spage=321;epage=327;aulast=Kukrety |
| _version_ | 1811239395864346624 |
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| author | Shweta P Kukrety Jai D Parekh Kristina L Bailey |
| author_facet | Shweta P Kukrety Jai D Parekh Kristina L Bailey |
| author_sort | Shweta P Kukrety |
| collection | DOAJ |
| description | Aging is characterized by progressive deterioration of physiological integrity, decline in homeostasis, and degeneration of the tissues that occurs after the reproductive phase of life is complete, leading to impaired function. This deterioration is an important risk factor for chronic lung pathologies such as chronic obstructive pulmonary disease (COPD). COPD is a disease that develops gradually. Emphysematous changes in the lung take years to develop after exposure to cigarette smoke; hence, the vast majority of patients are elderly. There has been a dramatic increase in the life expectancy of the general population, resulting in an increased burden of chronic lung diseases. There is growing evidence that molecular mechanisms involved in aging may also play a role in COPD pathogenesis. Recently, the nine hallmarks of aging were identified. In this article, we will review the nine hallmarks of aging and how each hallmark contributes to the pathogenesis of COPD. |
| first_indexed | 2024-04-12T13:00:00Z |
| format | Article |
| id | doaj.art-59c2a840ee524499859d2046df5afdd8 |
| institution | Directory Open Access Journal |
| issn | 0970-2113 0974-598X |
| language | English |
| last_indexed | 2024-04-12T13:00:00Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Lung India |
| spelling | doaj.art-59c2a840ee524499859d2046df5afdd82022-12-22T03:32:11ZengWolters Kluwer Medknow PublicationsLung India0970-21130974-598X2018-01-0135432132710.4103/lungindia.lungindia_266_17Chronic obstructive pulmonary disease and the hallmarks of agingShweta P KukretyJai D ParekhKristina L BaileyAging is characterized by progressive deterioration of physiological integrity, decline in homeostasis, and degeneration of the tissues that occurs after the reproductive phase of life is complete, leading to impaired function. This deterioration is an important risk factor for chronic lung pathologies such as chronic obstructive pulmonary disease (COPD). COPD is a disease that develops gradually. Emphysematous changes in the lung take years to develop after exposure to cigarette smoke; hence, the vast majority of patients are elderly. There has been a dramatic increase in the life expectancy of the general population, resulting in an increased burden of chronic lung diseases. There is growing evidence that molecular mechanisms involved in aging may also play a role in COPD pathogenesis. Recently, the nine hallmarks of aging were identified. In this article, we will review the nine hallmarks of aging and how each hallmark contributes to the pathogenesis of COPD.http://www.lungindia.com/article.asp?issn=0970-2113;year=2018;volume=35;issue=4;spage=321;epage=327;aulast=KukretyCellular senescencedysregulated nutrient sensingemphysemaepigenetic alterationsgenetic instabilityloss of proteostasismitochondrial dysfunctionsmokingstem cell exhaustion and altered intercellular communicationstelomere attrition |
| spellingShingle | Shweta P Kukrety Jai D Parekh Kristina L Bailey Chronic obstructive pulmonary disease and the hallmarks of aging Lung India Cellular senescence dysregulated nutrient sensing emphysema epigenetic alterations genetic instability loss of proteostasis mitochondrial dysfunction smoking stem cell exhaustion and altered intercellular communications telomere attrition |
| title | Chronic obstructive pulmonary disease and the hallmarks of aging |
| title_full | Chronic obstructive pulmonary disease and the hallmarks of aging |
| title_fullStr | Chronic obstructive pulmonary disease and the hallmarks of aging |
| title_full_unstemmed | Chronic obstructive pulmonary disease and the hallmarks of aging |
| title_short | Chronic obstructive pulmonary disease and the hallmarks of aging |
| title_sort | chronic obstructive pulmonary disease and the hallmarks of aging |
| topic | Cellular senescence dysregulated nutrient sensing emphysema epigenetic alterations genetic instability loss of proteostasis mitochondrial dysfunction smoking stem cell exhaustion and altered intercellular communications telomere attrition |
| url | http://www.lungindia.com/article.asp?issn=0970-2113;year=2018;volume=35;issue=4;spage=321;epage=327;aulast=Kukrety |
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