Management of psychosis in patients with Alzheimer’s disease: focus on aripiprazole
Subramanian Madhusoodanan1, Payal Shah21St John’s Episcopal Hospital Far Rockaway, NY 11691, SUNY, Brooklyn NY, USA. 2SUNY Health Science Center, Brooklyn, NYAbstract: Psychosis of Alzheimer’s disease (AD) is characterized by delusions or hallucinations and may be associated with...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2008-09-01
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| Series: | Clinical Interventions in Aging |
| Subjects: | |
| Online Access: | https://www.dovepress.com/management-of-psychosis-in-patients-with-alzheimerrsquos-disease-focus-peer-reviewed-article-CIA |
| _version_ | 1818345778724208640 |
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| author | Subramanian Madhusoodanan Payal Shah |
| author_facet | Subramanian Madhusoodanan Payal Shah |
| author_sort | Subramanian Madhusoodanan |
| collection | DOAJ |
| description | Subramanian Madhusoodanan1, Payal Shah21St John’s Episcopal Hospital Far Rockaway, NY 11691, SUNY, Brooklyn NY, USA. 2SUNY Health Science Center, Brooklyn, NYAbstract: Psychosis of Alzheimer’s disease (AD) is characterized by delusions or hallucinations and may be associated with agitation, negative symptoms or depression. There are no psychotropic medications that are approved by the US FDA for the treatment of psychosis of AD. However, atypical antipsychotics have been widely used and recommended by geriatric experts in the management of psychosis of AD in view of the modest efficacy and relative safety until FDA warnings were issued in 2005 and meta-analytic studies showed no significant difference to placebo. The FDA warnings on the cardiac, metabolic, cerebrovascular, and mortality risks have caused serious concerns for the use of atypical antipsychotic agents in elderly patients with dementia. Only a few studies have evaluated prospectively the effects of aripiprazole in psychosis associated with AD. These studies show improvement in the symptoms of psychosis associated with AD with aripiprazole. The safety and tolerability profile of aripiprazole suggests a low potential for negative impact on dementia and overall patient health. Further studies comparing the efficacy and tolerability of aripiprazole vs other atypical antipsychotics in dementia are needed.Keywords: treatment, Alzheimer’s dementia, psychosis, aripiprazole |
| first_indexed | 2024-12-13T17:07:47Z |
| format | Article |
| id | doaj.art-59c72234c0a0492db3db2960ee8d3a50 |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-12-13T17:07:47Z |
| publishDate | 2008-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-59c72234c0a0492db3db2960ee8d3a502022-12-21T23:37:38ZengDove Medical PressClinical Interventions in Aging1178-19982008-09-01Volume 34915012339Management of psychosis in patients with Alzheimer’s disease: focus on aripiprazoleSubramanian MadhusoodananPayal ShahSubramanian Madhusoodanan1, Payal Shah21St John’s Episcopal Hospital Far Rockaway, NY 11691, SUNY, Brooklyn NY, USA. 2SUNY Health Science Center, Brooklyn, NYAbstract: Psychosis of Alzheimer’s disease (AD) is characterized by delusions or hallucinations and may be associated with agitation, negative symptoms or depression. There are no psychotropic medications that are approved by the US FDA for the treatment of psychosis of AD. However, atypical antipsychotics have been widely used and recommended by geriatric experts in the management of psychosis of AD in view of the modest efficacy and relative safety until FDA warnings were issued in 2005 and meta-analytic studies showed no significant difference to placebo. The FDA warnings on the cardiac, metabolic, cerebrovascular, and mortality risks have caused serious concerns for the use of atypical antipsychotic agents in elderly patients with dementia. Only a few studies have evaluated prospectively the effects of aripiprazole in psychosis associated with AD. These studies show improvement in the symptoms of psychosis associated with AD with aripiprazole. The safety and tolerability profile of aripiprazole suggests a low potential for negative impact on dementia and overall patient health. Further studies comparing the efficacy and tolerability of aripiprazole vs other atypical antipsychotics in dementia are needed.Keywords: treatment, Alzheimer’s dementia, psychosis, aripiprazolehttps://www.dovepress.com/management-of-psychosis-in-patients-with-alzheimerrsquos-disease-focus-peer-reviewed-article-CIATreatmentAlzheimer’s DementiaPsychosisAripiprazole |
| spellingShingle | Subramanian Madhusoodanan Payal Shah Management of psychosis in patients with Alzheimer’s disease: focus on aripiprazole Clinical Interventions in Aging Treatment Alzheimer’s Dementia Psychosis Aripiprazole |
| title | Management of psychosis in patients with Alzheimer’s disease: focus on aripiprazole |
| title_full | Management of psychosis in patients with Alzheimer’s disease: focus on aripiprazole |
| title_fullStr | Management of psychosis in patients with Alzheimer’s disease: focus on aripiprazole |
| title_full_unstemmed | Management of psychosis in patients with Alzheimer’s disease: focus on aripiprazole |
| title_short | Management of psychosis in patients with Alzheimer’s disease: focus on aripiprazole |
| title_sort | management of psychosis in patients with alzheimer rsquo s disease focus on aripiprazole |
| topic | Treatment Alzheimer’s Dementia Psychosis Aripiprazole |
| url | https://www.dovepress.com/management-of-psychosis-in-patients-with-alzheimerrsquos-disease-focus-peer-reviewed-article-CIA |
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