Crystal structures of human pyridoxal kinase in complex with the neurotoxins, ginkgotoxin and theophylline: insights into pyridoxal kinase inhibition.

Crystal structures of human pyridoxal kinase in complex with the neurotoxins, ginkgotoxin and theophylline: insights into pyridoxal kinase inhibition.

Several drugs and natural compounds are known to be highly neurotoxic, triggering epileptic convulsions or seizures, and causing headaches, agitations, as well as other neuronal symptoms. The neurotoxic effects of some of these compounds, including theophylline and ginkgotoxin, have been traced to t...

Full description

Bibliographic Details
Main Authors: Amit K Gandhi, Jigar V Desai, Mohini S Ghatge, Martino L di Salvo, Stefano Di Biase, Richmond Danso-Danquah, Faik N Musayev, Roberto Contestabile, Verne Schirch, Martin K Safo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3412620?pdf=render

Internet

http://europepmc.org/articles/PMC3412620?pdf=render

Similar Items