Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation

Abstract Ribosome profiling data report on the distribution of translating ribosomes, at steady‐state, with codon‐level resolution. We present a robust method to extract codon translation rates and protein synthesis rates from these data, and identify causal features associated with elongation and t...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Cristina Pop, Silvi Rouskin, Nicholas T Ingolia, Lu Han, Eric M Phizicky, Jonathan S Weissman, Daphne Koller
التنسيق: مقال
اللغة:English
منشور في: Springer Nature 2014-12-01
سلاسل:Molecular Systems Biology
الموضوعات:
الوصول للمادة أونلاين:https://doi.org/10.15252/msb.20145524