The inhibiting effect of alpha-based TARE on embolized vessels and neovascularization
Transarterial embolization (TAE) is a personalized technology that offers precise delivery of chemotherapeutic drugs or selective internal radiation therapy for hepatocellular carcinoma (HCC). Beta-emitting radionuclide embolisms for TAE (β-based TARE) are commonly used in the clinic via inducing bi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1021499/full |
| _version_ | 1798021133394509824 |
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| author | Qianqian Tong Qianqian Tong Rou Li Ruizhi Wang Changjing Zuo Danni Li Guorong Jia Ye Peng Xiaohong Li Jian Yang Shuai Xue Qingyun Bai Xiao Li Xiao Li |
| author_facet | Qianqian Tong Qianqian Tong Rou Li Ruizhi Wang Changjing Zuo Danni Li Guorong Jia Ye Peng Xiaohong Li Jian Yang Shuai Xue Qingyun Bai Xiao Li Xiao Li |
| author_sort | Qianqian Tong |
| collection | DOAJ |
| description | Transarterial embolization (TAE) is a personalized technology that offers precise delivery of chemotherapeutic drugs or selective internal radiation therapy for hepatocellular carcinoma (HCC). Beta-emitting radionuclide embolisms for TAE (β-based TARE) are commonly used in the clinic via inducing biochemical lethality on tumor cells, while alpha-emitting radionuclides-based embolisms for TAE (α-based TARE) are still under study. The feeding artery plays a key role in tumor growth, metastasis, and recurrence. In this research, the auricular central arteries (ACAs) of rabbits were embolized with silk fibroin-based microspheres (SFMs) or SFMs integrated with α (Ra-223) or β (I-131) radionuclides to investigate the influence on vessels. TARE-induced tissue necrosis and the following neovascularization were measured by pathological analysis and 68Ga-DOTA-RGD PET/CT. The results showed that, compared to I-131, Ra-223 enhanced the growth inhibition of human hepatoma cells Huh-7 and induced more DNA double-strand breaks in vascular smooth muscle cells. Unlike β-based TARE, which mainly led to extensive necrosis of surrounding tissues, α-based TARE induced irreversible necrosis of a limited area adjacent to the embolized vessels. RGD PET revealed the inhibition on neovascularization in α-based TARE (SUVmax = 0.053 ± 0.004) when compared with normal group (SUVmax = 0.099 ± 0.036), the SFMs-lipiodol group (SUVmax = 0.240 ± 0.040), and β-based TARE (SUVmax = 0.141 ± 0.026), owing to the avoidance of the embolism-induced neovascularization. In conclusion, α-based TARE provided a promising strategy for HCC treatments via destroying the embolized vessels and inhibiting neovascularization. |
| first_indexed | 2024-04-11T17:09:07Z |
| format | Article |
| id | doaj.art-59c85fca3f3e491c8cc7db60a4b4c3bc |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-11T17:09:07Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-59c85fca3f3e491c8cc7db60a4b4c3bc2022-12-22T04:12:57ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-10-011010.3389/fbioe.2022.10214991021499The inhibiting effect of alpha-based TARE on embolized vessels and neovascularizationQianqian Tong0Qianqian Tong1Rou Li2Ruizhi Wang3Changjing Zuo4Danni Li5Guorong Jia6Ye Peng7Xiaohong Li8Jian Yang9Shuai Xue10Qingyun Bai11Xiao Li12Xiao Li13School of Chemistry and Bioengineering, Yichun University, Yichun, Jiangxi, ChinaDepartment of Nuclear Medicine, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Nuclear Medicine, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Radiology, Huadong Hospital, Fudan University, Shanghai, ChinaDepartment of Nuclear Medicine, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Nuclear Medicine, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Nuclear Medicine, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Nuclear Medicine, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Nuclear Medicine, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Nuclear Medicine, Changhai Hospital, Naval Medical University, Shanghai, ChinaSchool of Chemistry and Bioengineering, Yichun University, Yichun, Jiangxi, ChinaSchool of Chemistry and Bioengineering, Yichun University, Yichun, Jiangxi, ChinaDepartment of Nuclear Medicine, Changhai Hospital, Naval Medical University, Shanghai, ChinaInstitute of Applied Physics, Chinese Academy of Sciences, Shanghai, ChinaTransarterial embolization (TAE) is a personalized technology that offers precise delivery of chemotherapeutic drugs or selective internal radiation therapy for hepatocellular carcinoma (HCC). Beta-emitting radionuclide embolisms for TAE (β-based TARE) are commonly used in the clinic via inducing biochemical lethality on tumor cells, while alpha-emitting radionuclides-based embolisms for TAE (α-based TARE) are still under study. The feeding artery plays a key role in tumor growth, metastasis, and recurrence. In this research, the auricular central arteries (ACAs) of rabbits were embolized with silk fibroin-based microspheres (SFMs) or SFMs integrated with α (Ra-223) or β (I-131) radionuclides to investigate the influence on vessels. TARE-induced tissue necrosis and the following neovascularization were measured by pathological analysis and 68Ga-DOTA-RGD PET/CT. The results showed that, compared to I-131, Ra-223 enhanced the growth inhibition of human hepatoma cells Huh-7 and induced more DNA double-strand breaks in vascular smooth muscle cells. Unlike β-based TARE, which mainly led to extensive necrosis of surrounding tissues, α-based TARE induced irreversible necrosis of a limited area adjacent to the embolized vessels. RGD PET revealed the inhibition on neovascularization in α-based TARE (SUVmax = 0.053 ± 0.004) when compared with normal group (SUVmax = 0.099 ± 0.036), the SFMs-lipiodol group (SUVmax = 0.240 ± 0.040), and β-based TARE (SUVmax = 0.141 ± 0.026), owing to the avoidance of the embolism-induced neovascularization. In conclusion, α-based TARE provided a promising strategy for HCC treatments via destroying the embolized vessels and inhibiting neovascularization.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1021499/fullhepatocellular carcinomatransarterial radioembolizationα radionuclidesRa-223neovascularizationsilk fibroin |
| spellingShingle | Qianqian Tong Qianqian Tong Rou Li Ruizhi Wang Changjing Zuo Danni Li Guorong Jia Ye Peng Xiaohong Li Jian Yang Shuai Xue Qingyun Bai Xiao Li Xiao Li The inhibiting effect of alpha-based TARE on embolized vessels and neovascularization Frontiers in Bioengineering and Biotechnology hepatocellular carcinoma transarterial radioembolization α radionuclides Ra-223 neovascularization silk fibroin |
| title | The inhibiting effect of alpha-based TARE on embolized vessels and neovascularization |
| title_full | The inhibiting effect of alpha-based TARE on embolized vessels and neovascularization |
| title_fullStr | The inhibiting effect of alpha-based TARE on embolized vessels and neovascularization |
| title_full_unstemmed | The inhibiting effect of alpha-based TARE on embolized vessels and neovascularization |
| title_short | The inhibiting effect of alpha-based TARE on embolized vessels and neovascularization |
| title_sort | inhibiting effect of alpha based tare on embolized vessels and neovascularization |
| topic | hepatocellular carcinoma transarterial radioembolization α radionuclides Ra-223 neovascularization silk fibroin |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1021499/full |
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