Prevalence of Down’s Syndrome in Patients of Congenital Heart Disease in Vidarbha Region Central India
Introduction: Down’s syndrome is a genetic state in which a person has 47 chromosomes instead of 46, with an additional copy of chromosome number 21. This additional genetic material disorders the normal growth process leading to medical and physical defects in cases of Down’s syndrome. Childre...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Pvt. Ltd.
2017-04-01
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| Series: | International Journal of Anatomy Radiology and Surgery |
| Subjects: | |
| Online Access: | http://www.ijars.net/articles/PDF/2249/23429_CE[VSU]_F(GH)_PF1(VsuGH)_PFA(GH)_PF2(VsuGH).pdf |
| Summary: | Introduction: Down’s syndrome is a genetic state in
which a person has 47 chromosomes instead of 46,
with an additional copy of chromosome number 21. This
additional genetic material disorders the normal growth
process leading to medical and physical defects in cases
of Down’s syndrome. Children with Down’s syndrome
are distinguished by mental retardation and typical facial
features but they also have high occurrence of a variety of
Congenital Heart Disease (CHD).
Aim: This study was done with an aim to estimate the
occurrences of CHD among the patients with Down’s
syndrome.
Materials and Methods: In this cross-sectional study, 374
cases of heart disease from age group of 0 to 14 years were
studied for the occurrence of Down’s syndrome during the
period of 2008 to 2012. The standard karyotyping method
was used to confirm Down’s syndrome. The normal
children of equivalent age group were taken as control. The
heart defects were also collected. The collected data was
compared with the globally accepted statistics of Down’s
syndrome.
Results: Out of 374 diagnosed cases of CHD, seven cases
(four males and three females) were confirmed with the
Down’s syndrome (1.87%). The Down’s syndrome frequency
(1.87%) which is significantly very high in comparison with
the age matched control patient’s frequency of 0.1% (1 in
1000).
Conclusion: CHDs were prevalent in the children with
Down’s syndrome, whereas the prevalence of CHD was
significantly low when compared to controls of same age
groups. The frequency of CHD among children with Down’s
syndrome is found to be 1.87%. The CHD may appear with
the birth and are more common in Down’s syndrome. |
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| ISSN: | 2277-8543 2455-6874 |