Age at menopause is inversely related to the prevalence of common gynecologic cancers: a study based on NHANES
BackgroundThe fluctuation or even loss of estrogen level caused by menopause in women, and most gynecological cancers often occur before and after menopause, so the age of menopause may be related to the occurrence of gynecological cancer.AimTo investigate whether the age at menopause is independent...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1218045/full |
| _version_ | 1797623536803643392 |
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| author | Guangdong Cheng Mengmeng Wang Hao Sun Jingjiang Lai Yukun Feng Hongjin Liu Yuwang Shang Yuan Zhao Bingli Zuo Youhua Lu |
| author_facet | Guangdong Cheng Mengmeng Wang Hao Sun Jingjiang Lai Yukun Feng Hongjin Liu Yuwang Shang Yuan Zhao Bingli Zuo Youhua Lu |
| author_sort | Guangdong Cheng |
| collection | DOAJ |
| description | BackgroundThe fluctuation or even loss of estrogen level caused by menopause in women, and most gynecological cancers often occur before and after menopause, so the age of menopause may be related to the occurrence of gynecological cancer.AimTo investigate whether the age at menopause is independently associated with the incidence of gynecological cancers and to analyze the possible influencing factors.MethodsWe selected the NHANES public database to conduct the study, and by excluding relevant influencing factors, we finally included 5706 NHANES participants who had full data on age at menopause and the occurrence of gynecologic cancers to analyze the relationship between the amount of age at menopause and gynecologic cancers based on univariate or multifactorial logistic regression analysis. Further, the relationship between age at menopause and the prevalence of different gynecologic cancers was investigated, and changes in the prevalence of different gynecologic cancers by age at menopause subgroups were observed. Finally, other relevant factors affecting the prevalence of gynecologic cancers were further investigated by subgroup analysis as well as subcluster analysis.ResultsUnivariate logistic regression analysis between age at menopause and gynecologic tumor prevalence revealed a negative association between age at menopause and the prevalence of common gynecologic cancers ovarian and cervical cancer, and after adjusting for the effects of covariates, a higher risk of gynecologic tumors was found with statistically significant differences at earlier age at menopause. The regression results showed a negative association between age at menopause and gynecologic cancer prevalence in cervical and ovarian cancer patients (P<0.01,P<0.01). Cervical cancer (OR: 0.91, 95% CI: 0.87,0.94) and ovarian cancer (OR: 0.90, 95% CI: 0.86, 0.95) were more prevalent among those with younger age at menopause.ConclusionAge at menopause is negatively associated with the prevalence of cervical and ovarian cancers, and the earlier the age at menopause, the greater the risk of developing gynecological cancers. |
| first_indexed | 2024-03-11T09:30:20Z |
| format | Article |
| id | doaj.art-59c9bc5e541c4f479e0c1c8d16e5cc6a |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-11T09:30:20Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-59c9bc5e541c4f479e0c1c8d16e5cc6a2023-11-16T17:41:22ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-11-011410.3389/fendo.2023.12180451218045Age at menopause is inversely related to the prevalence of common gynecologic cancers: a study based on NHANESGuangdong Cheng0Mengmeng Wang1Hao Sun2Jingjiang Lai3Yukun Feng4Hongjin Liu5Yuwang Shang6Yuan Zhao7Bingli Zuo8Youhua Lu9Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaXiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaShandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaInnovative Institute of Chinese Medicine, Shandong University of Traditional Chinese 25 Medicine, Jinan, ChinaShandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaShandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaShandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaShandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaBackgroundThe fluctuation or even loss of estrogen level caused by menopause in women, and most gynecological cancers often occur before and after menopause, so the age of menopause may be related to the occurrence of gynecological cancer.AimTo investigate whether the age at menopause is independently associated with the incidence of gynecological cancers and to analyze the possible influencing factors.MethodsWe selected the NHANES public database to conduct the study, and by excluding relevant influencing factors, we finally included 5706 NHANES participants who had full data on age at menopause and the occurrence of gynecologic cancers to analyze the relationship between the amount of age at menopause and gynecologic cancers based on univariate or multifactorial logistic regression analysis. Further, the relationship between age at menopause and the prevalence of different gynecologic cancers was investigated, and changes in the prevalence of different gynecologic cancers by age at menopause subgroups were observed. Finally, other relevant factors affecting the prevalence of gynecologic cancers were further investigated by subgroup analysis as well as subcluster analysis.ResultsUnivariate logistic regression analysis between age at menopause and gynecologic tumor prevalence revealed a negative association between age at menopause and the prevalence of common gynecologic cancers ovarian and cervical cancer, and after adjusting for the effects of covariates, a higher risk of gynecologic tumors was found with statistically significant differences at earlier age at menopause. The regression results showed a negative association between age at menopause and gynecologic cancer prevalence in cervical and ovarian cancer patients (P<0.01,P<0.01). Cervical cancer (OR: 0.91, 95% CI: 0.87,0.94) and ovarian cancer (OR: 0.90, 95% CI: 0.86, 0.95) were more prevalent among those with younger age at menopause.ConclusionAge at menopause is negatively associated with the prevalence of cervical and ovarian cancers, and the earlier the age at menopause, the greater the risk of developing gynecological cancers.https://www.frontiersin.org/articles/10.3389/fendo.2023.1218045/fullretrospective studymenopausecancergynecologyNHANES |
| spellingShingle | Guangdong Cheng Mengmeng Wang Hao Sun Jingjiang Lai Yukun Feng Hongjin Liu Yuwang Shang Yuan Zhao Bingli Zuo Youhua Lu Age at menopause is inversely related to the prevalence of common gynecologic cancers: a study based on NHANES Frontiers in Endocrinology retrospective study menopause cancer gynecology NHANES |
| title | Age at menopause is inversely related to the prevalence of common gynecologic cancers: a study based on NHANES |
| title_full | Age at menopause is inversely related to the prevalence of common gynecologic cancers: a study based on NHANES |
| title_fullStr | Age at menopause is inversely related to the prevalence of common gynecologic cancers: a study based on NHANES |
| title_full_unstemmed | Age at menopause is inversely related to the prevalence of common gynecologic cancers: a study based on NHANES |
| title_short | Age at menopause is inversely related to the prevalence of common gynecologic cancers: a study based on NHANES |
| title_sort | age at menopause is inversely related to the prevalence of common gynecologic cancers a study based on nhanes |
| topic | retrospective study menopause cancer gynecology NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1218045/full |
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