Effect and Safety of Helicobacter pylori Eradication Treatment Based on Molecular Pathologic Antibiotic Resistance in Chinese Elderly People
Chun Gao, Yan-Hua Fan Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of ChinaCorrespondence: Yan-Hua Fan, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Beijing, 100029, People’s Republic of China, Tel/Fa...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-06-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/effect-and-safety-of-helicobacter-pylori-eradication-treatment-based-o-peer-reviewed-fulltext-article-IDR |
| _version_ | 1811332021484519424 |
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| author | Gao C Fan YH |
| author_facet | Gao C Fan YH |
| author_sort | Gao C |
| collection | DOAJ |
| description | Chun Gao, Yan-Hua Fan Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of ChinaCorrespondence: Yan-Hua Fan, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Beijing, 100029, People’s Republic of China, Tel/Fax +86 10-84205503, Email fanyanhua@zryhyy.com.cnBackground: The elderly people generally have poor tolerance to drugs and an increased risk of adverse effects. Our study was designed to determine the effect and safety of Helicobacter pylori (H. pylori) eradication treatment based on molecular pathologic antibiotic resistance in Chinese elderly people over the age of 60 years.Methods: A total of 364 people were retrospectively analyzed, including 113 older people over 60 and 251 young and middle-aged people in the age of 20– 59 years. Real-time PCR detection and conventional PCR and sequencing method were used for drug susceptibility testing. As the main outcome measure, the eradication rates (ERs) with their 95% confidence intervals (CIs) were analyzed by intention to treat (ITT) and per protocol (PP). For the safety of therapy, adverse events were analyzed.Results: For the total people, the resistance rates to clarithromycin (CLR), amoxicillin (AMX), fluoroquinolone (FLQ) and tetracycline (TET) were 65.06%, 7.54%, 61.39% and 20.37%, respectively. After they were divided into two groups, the resistance rates were 62.39% (CLR), 9.09% (AMX), 69.64% (FLQ) and 22.45% (TET) in the 113 older people over 60, and 66.26%, 6.85%, 57.66% and 19.47% in the 251 young and middle-aged people in 20– 59. By the ITT analysis, the ERs were 92.04% (95% CI, 86.97– 97.10%, n=113) in the older people and 92.43% (95% CI, 89.14– 95.73%, n=251) in the young and middle-aged people. By the PP analysis, the ERs were 96.30% (95% CI, 92.68– 99.92%, n=108) and 94.69% (95% CI, 91.87– 97.52%, n=245), respectively. No significant differences were shown both in the ITT analysis (P=0.896) and in the PP analysis (P=0.517). The three most common adverse events were black stool, dysgeusia and diarrhea, and no serious adverse event was reported.Conclusion: H. pylori eradication treatment based on molecular pathologic antibiotic resistance showed good effect and safety in Chinese elderly people.Keywords: Helicobacter pylori, antibiotic resistance, elderly people, molecular pathology, eradication treatment |
| first_indexed | 2024-04-13T16:30:28Z |
| format | Article |
| id | doaj.art-59cb97418efb420d8206182b3cb68049 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-13T16:30:28Z |
| publishDate | 2022-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-59cb97418efb420d8206182b3cb680492022-12-22T02:39:36ZengDove Medical PressInfection and Drug Resistance1178-69732022-06-01Volume 153277328676101Effect and Safety of Helicobacter pylori Eradication Treatment Based on Molecular Pathologic Antibiotic Resistance in Chinese Elderly PeopleGao CFan YHChun Gao, Yan-Hua Fan Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of ChinaCorrespondence: Yan-Hua Fan, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Beijing, 100029, People’s Republic of China, Tel/Fax +86 10-84205503, Email fanyanhua@zryhyy.com.cnBackground: The elderly people generally have poor tolerance to drugs and an increased risk of adverse effects. Our study was designed to determine the effect and safety of Helicobacter pylori (H. pylori) eradication treatment based on molecular pathologic antibiotic resistance in Chinese elderly people over the age of 60 years.Methods: A total of 364 people were retrospectively analyzed, including 113 older people over 60 and 251 young and middle-aged people in the age of 20– 59 years. Real-time PCR detection and conventional PCR and sequencing method were used for drug susceptibility testing. As the main outcome measure, the eradication rates (ERs) with their 95% confidence intervals (CIs) were analyzed by intention to treat (ITT) and per protocol (PP). For the safety of therapy, adverse events were analyzed.Results: For the total people, the resistance rates to clarithromycin (CLR), amoxicillin (AMX), fluoroquinolone (FLQ) and tetracycline (TET) were 65.06%, 7.54%, 61.39% and 20.37%, respectively. After they were divided into two groups, the resistance rates were 62.39% (CLR), 9.09% (AMX), 69.64% (FLQ) and 22.45% (TET) in the 113 older people over 60, and 66.26%, 6.85%, 57.66% and 19.47% in the 251 young and middle-aged people in 20– 59. By the ITT analysis, the ERs were 92.04% (95% CI, 86.97– 97.10%, n=113) in the older people and 92.43% (95% CI, 89.14– 95.73%, n=251) in the young and middle-aged people. By the PP analysis, the ERs were 96.30% (95% CI, 92.68– 99.92%, n=108) and 94.69% (95% CI, 91.87– 97.52%, n=245), respectively. No significant differences were shown both in the ITT analysis (P=0.896) and in the PP analysis (P=0.517). The three most common adverse events were black stool, dysgeusia and diarrhea, and no serious adverse event was reported.Conclusion: H. pylori eradication treatment based on molecular pathologic antibiotic resistance showed good effect and safety in Chinese elderly people.Keywords: Helicobacter pylori, antibiotic resistance, elderly people, molecular pathology, eradication treatmenthttps://www.dovepress.com/effect-and-safety-of-helicobacter-pylori-eradication-treatment-based-o-peer-reviewed-fulltext-article-IDRhelicobacter pyloriantibiotic resistanceelderly peoplemolecular pathologyeradication treatment |
| spellingShingle | Gao C Fan YH Effect and Safety of Helicobacter pylori Eradication Treatment Based on Molecular Pathologic Antibiotic Resistance in Chinese Elderly People Infection and Drug Resistance helicobacter pylori antibiotic resistance elderly people molecular pathology eradication treatment |
| title | Effect and Safety of Helicobacter pylori Eradication Treatment Based on Molecular Pathologic Antibiotic Resistance in Chinese Elderly People |
| title_full | Effect and Safety of Helicobacter pylori Eradication Treatment Based on Molecular Pathologic Antibiotic Resistance in Chinese Elderly People |
| title_fullStr | Effect and Safety of Helicobacter pylori Eradication Treatment Based on Molecular Pathologic Antibiotic Resistance in Chinese Elderly People |
| title_full_unstemmed | Effect and Safety of Helicobacter pylori Eradication Treatment Based on Molecular Pathologic Antibiotic Resistance in Chinese Elderly People |
| title_short | Effect and Safety of Helicobacter pylori Eradication Treatment Based on Molecular Pathologic Antibiotic Resistance in Chinese Elderly People |
| title_sort | effect and safety of helicobacter pylori eradication treatment based on molecular pathologic antibiotic resistance in chinese elderly people |
| topic | helicobacter pylori antibiotic resistance elderly people molecular pathology eradication treatment |
| url | https://www.dovepress.com/effect-and-safety-of-helicobacter-pylori-eradication-treatment-based-o-peer-reviewed-fulltext-article-IDR |
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