Pegylated interferon-alpha-2a for the treatment of ocular surface squamous neoplasia
Ocular surface squamous neoplasia (OSSN) is the most common nonpigmented ocular surface neoplasm. Interferon-alpha (IFNα)-2b has been proved to be an effective immunotherapeutic agent to treat OSSN. We have used intralesional and topical (36 μg/ml) pegylated (peg) IFNα-2a to treat a recurrent surgic...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Oman Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ojoonline.org/article.asp?issn=0974-620X;year=2022;volume=15;issue=1;spage=81;epage=84;aulast=Nuruddin |
| _version_ | 1797995505403297792 |
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| author | Murtuza Nuruddin Soma Rani Roy Fahmida Hoque |
| author_facet | Murtuza Nuruddin Soma Rani Roy Fahmida Hoque |
| author_sort | Murtuza Nuruddin |
| collection | DOAJ |
| description | Ocular surface squamous neoplasia (OSSN) is the most common nonpigmented ocular surface neoplasm. Interferon-alpha (IFNα)-2b has been proved to be an effective immunotherapeutic agent to treat OSSN. We have used intralesional and topical (36 μg/ml) pegylated (peg) IFNα-2a to treat a recurrent surgically failed case of OSSN instead of IFNα-2b. In this case report, we have shared our initial experience with the novel use of peg-IFNα-2a to treat OSSN. According to our brief clinical experience, peg-IFNα-2a is nontoxic to ocular surface and has a promising role to treat OSSN. |
| first_indexed | 2024-04-11T10:02:49Z |
| format | Article |
| id | doaj.art-59d08cb10a9b432fa79b52f8e0f8f167 |
| institution | Directory Open Access Journal |
| issn | 0974-620X |
| language | English |
| last_indexed | 2024-04-11T10:02:49Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Oman Journal of Ophthalmology |
| spelling | doaj.art-59d08cb10a9b432fa79b52f8e0f8f1672022-12-22T04:30:20ZengWolters Kluwer Medknow PublicationsOman Journal of Ophthalmology0974-620X2022-01-01151818410.4103/ojo.ojo_146_21Pegylated interferon-alpha-2a for the treatment of ocular surface squamous neoplasiaMurtuza NuruddinSoma Rani RoyFahmida HoqueOcular surface squamous neoplasia (OSSN) is the most common nonpigmented ocular surface neoplasm. Interferon-alpha (IFNα)-2b has been proved to be an effective immunotherapeutic agent to treat OSSN. We have used intralesional and topical (36 μg/ml) pegylated (peg) IFNα-2a to treat a recurrent surgically failed case of OSSN instead of IFNα-2b. In this case report, we have shared our initial experience with the novel use of peg-IFNα-2a to treat OSSN. According to our brief clinical experience, peg-IFNα-2a is nontoxic to ocular surface and has a promising role to treat OSSN.http://www.ojoonline.org/article.asp?issn=0974-620X;year=2022;volume=15;issue=1;spage=81;epage=84;aulast=Nuruddininterferon-alpha-2ainterferon-alpha-2bocular surface neoplasm |
| spellingShingle | Murtuza Nuruddin Soma Rani Roy Fahmida Hoque Pegylated interferon-alpha-2a for the treatment of ocular surface squamous neoplasia Oman Journal of Ophthalmology interferon-alpha-2a interferon-alpha-2b ocular surface neoplasm |
| title | Pegylated interferon-alpha-2a for the treatment of ocular surface squamous neoplasia |
| title_full | Pegylated interferon-alpha-2a for the treatment of ocular surface squamous neoplasia |
| title_fullStr | Pegylated interferon-alpha-2a for the treatment of ocular surface squamous neoplasia |
| title_full_unstemmed | Pegylated interferon-alpha-2a for the treatment of ocular surface squamous neoplasia |
| title_short | Pegylated interferon-alpha-2a for the treatment of ocular surface squamous neoplasia |
| title_sort | pegylated interferon alpha 2a for the treatment of ocular surface squamous neoplasia |
| topic | interferon-alpha-2a interferon-alpha-2b ocular surface neoplasm |
| url | http://www.ojoonline.org/article.asp?issn=0974-620X;year=2022;volume=15;issue=1;spage=81;epage=84;aulast=Nuruddin |
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