Chitosan hydrogel nanoparticle enhance therapeutic effect of bovine umbilical mesenchymal stem cell conditioned medium on canine cognitive dysfunction or canine alzheimer's like mediated by inhibition of neuronal apoptotic
In treating brain diseases, such as canine cognitive dysfunction, most currently available potent drugs have weak therapeutic efficacy. One of the causes is the inability of the substance to reach the brain in therapeutic quantities. These pharmaceuticals lacked targeted mechanisms for drug delivery...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Tripoli University
2023-12-01
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| Series: | Open Veterinary Journal |
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| Online Access: | https://www.openveterinaryjournal.com/?mno=162450 |
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| author | Hevi Wihadmadyatami Muhammad Ali Zulfikar Herawati Herawati Dyah Ayu O.A Pratama Golda Rani Saragih Ulayatul Kustiati Nurrahmi Handayani |
| author_facet | Hevi Wihadmadyatami Muhammad Ali Zulfikar Herawati Herawati Dyah Ayu O.A Pratama Golda Rani Saragih Ulayatul Kustiati Nurrahmi Handayani |
| author_sort | Hevi Wihadmadyatami |
| collection | DOAJ |
| description | In treating brain diseases, such as canine cognitive dysfunction, most currently available potent drugs have weak therapeutic efficacy. One of the causes is the inability of the substance to reach the brain in therapeutic quantities. These pharmaceuticals lacked targeted mechanisms for drug delivery, coming about in an elevated drugs concentration in imperative organs, which driven to drug harmfulness. In recent years, cell-free treatment (conditioned medium) determined from animal and human stem cells have provided new promise for treating brain diseases, as CM can stimulate the regeneration of neurons and prevent the inflammation and apoptotic of neurons caused by pathology or aging. On the other hand, it is well known that Chitosan-Hydrogel (CH) is a polymer derived from natural sources. It has been authorized for use in biomedical use because of its uncommon biodegradability, biocompatibility, and mucoadhesive properties. CH modification has been utilized to generate nanoparticles (NPs) for intranasal and intravenous brain targeting. NPs shown upgraded drug take-up to the brain with decreased side impacts due to their drawn out contact time with the nasal mucosa, surface charge, nano size, and capacity to extend the tight intersections inside the mucosa. Due to the aforementioned distinctive characteristics, developing CHNPs load with Bovine Umbilical Mesenchymal Stem Cell Conditioned Medium is crucial as a new therapeutic strategy for canine cognitive dysfunction. [Open Vet J 2023; 13(12.000): 1504-1516] |
| first_indexed | 2024-03-08T14:39:19Z |
| format | Article |
| id | doaj.art-59d0b085de9740739299104f16cff862 |
| institution | Directory Open Access Journal |
| issn | 2226-4485 2218-6050 |
| language | English |
| last_indexed | 2024-03-08T14:39:19Z |
| publishDate | 2023-12-01 |
| publisher | Tripoli University |
| record_format | Article |
| series | Open Veterinary Journal |
| spelling | doaj.art-59d0b085de9740739299104f16cff8622024-01-11T18:57:11ZengTripoli UniversityOpen Veterinary Journal2226-44852218-60502023-12-0113121504151610.5455/OVJ.2023.v13.i12.1162450Chitosan hydrogel nanoparticle enhance therapeutic effect of bovine umbilical mesenchymal stem cell conditioned medium on canine cognitive dysfunction or canine alzheimer's like mediated by inhibition of neuronal apoptoticHevi Wihadmadyatami0Muhammad Ali Zulfikar1Herawati Herawati2Dyah Ayu O.A Pratama3Golda Rani Saragih4Ulayatul Kustiati5Nurrahmi Handayani6Department of Anatomy, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia, 55281 Department of Chemistry, Bandung Institute of Technology, Bandung, Indonesia, 40132 Laboratory of Veterinary Public Health, Faculty of Veterinary Medicine, Brawijaya University, Malang, Indonesia, 65145 Laboratory of Pathology, Faculty of Veterinary Medicine, Brawijaya University, Malang, Indonesia, 65145 Department of Anatomy, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia, 55281 Laboratory of Pharmacology, Faculty of Veterinary Medicine, Brawijaya University, Malang, Indonesia, 65145 Department of Chemistry, Bandung Institute of Technology, Bandung, Indonesia, 40132In treating brain diseases, such as canine cognitive dysfunction, most currently available potent drugs have weak therapeutic efficacy. One of the causes is the inability of the substance to reach the brain in therapeutic quantities. These pharmaceuticals lacked targeted mechanisms for drug delivery, coming about in an elevated drugs concentration in imperative organs, which driven to drug harmfulness. In recent years, cell-free treatment (conditioned medium) determined from animal and human stem cells have provided new promise for treating brain diseases, as CM can stimulate the regeneration of neurons and prevent the inflammation and apoptotic of neurons caused by pathology or aging. On the other hand, it is well known that Chitosan-Hydrogel (CH) is a polymer derived from natural sources. It has been authorized for use in biomedical use because of its uncommon biodegradability, biocompatibility, and mucoadhesive properties. CH modification has been utilized to generate nanoparticles (NPs) for intranasal and intravenous brain targeting. NPs shown upgraded drug take-up to the brain with decreased side impacts due to their drawn out contact time with the nasal mucosa, surface charge, nano size, and capacity to extend the tight intersections inside the mucosa. Due to the aforementioned distinctive characteristics, developing CHNPs load with Bovine Umbilical Mesenchymal Stem Cell Conditioned Medium is crucial as a new therapeutic strategy for canine cognitive dysfunction. [Open Vet J 2023; 13(12.000): 1504-1516]https://www.openveterinaryjournal.com/?mno=162450bovine umbilical mesenchymal stem cellcanine cognitive dysfunctioncell-free therapychitosan hydrogel nanoparticlesecretome |
| spellingShingle | Hevi Wihadmadyatami Muhammad Ali Zulfikar Herawati Herawati Dyah Ayu O.A Pratama Golda Rani Saragih Ulayatul Kustiati Nurrahmi Handayani Chitosan hydrogel nanoparticle enhance therapeutic effect of bovine umbilical mesenchymal stem cell conditioned medium on canine cognitive dysfunction or canine alzheimer's like mediated by inhibition of neuronal apoptotic Open Veterinary Journal bovine umbilical mesenchymal stem cell canine cognitive dysfunction cell-free therapy chitosan hydrogel nanoparticle secretome |
| title | Chitosan hydrogel nanoparticle enhance therapeutic effect of bovine umbilical mesenchymal stem cell conditioned medium on canine cognitive dysfunction or canine alzheimer's like mediated by inhibition of neuronal apoptotic |
| title_full | Chitosan hydrogel nanoparticle enhance therapeutic effect of bovine umbilical mesenchymal stem cell conditioned medium on canine cognitive dysfunction or canine alzheimer's like mediated by inhibition of neuronal apoptotic |
| title_fullStr | Chitosan hydrogel nanoparticle enhance therapeutic effect of bovine umbilical mesenchymal stem cell conditioned medium on canine cognitive dysfunction or canine alzheimer's like mediated by inhibition of neuronal apoptotic |
| title_full_unstemmed | Chitosan hydrogel nanoparticle enhance therapeutic effect of bovine umbilical mesenchymal stem cell conditioned medium on canine cognitive dysfunction or canine alzheimer's like mediated by inhibition of neuronal apoptotic |
| title_short | Chitosan hydrogel nanoparticle enhance therapeutic effect of bovine umbilical mesenchymal stem cell conditioned medium on canine cognitive dysfunction or canine alzheimer's like mediated by inhibition of neuronal apoptotic |
| title_sort | chitosan hydrogel nanoparticle enhance therapeutic effect of bovine umbilical mesenchymal stem cell conditioned medium on canine cognitive dysfunction or canine alzheimer apos s like mediated by inhibition of neuronal apoptotic |
| topic | bovine umbilical mesenchymal stem cell canine cognitive dysfunction cell-free therapy chitosan hydrogel nanoparticle secretome |
| url | https://www.openveterinaryjournal.com/?mno=162450 |
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