IDO1/COX2 Expression Is Associated with Poor Prognosis in Colorectal Cancer Liver Oligometastases
Background: IDO1 and COX2 have emerged as promising immunotherapy targets. It is unclear whether IDO1 and COX2 expression levels in colorectal cancer (CRC) patients with liver oligometastases could be independent predictors of overall survival (OS) and progression-free survival (PFS). The purpose of...
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MDPI AG
2023-03-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/3/496 |
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| author | Miaoqing Wu Xiaoliang Wu Xing Wang Xiangchan Hong Yifan Liu Guangzhao Lv Cong Li Zhizhong Pan Rongxin Zhang Gong Chen |
| author_facet | Miaoqing Wu Xiaoliang Wu Xing Wang Xiangchan Hong Yifan Liu Guangzhao Lv Cong Li Zhizhong Pan Rongxin Zhang Gong Chen |
| author_sort | Miaoqing Wu |
| collection | DOAJ |
| description | Background: IDO1 and COX2 have emerged as promising immunotherapy targets. It is unclear whether IDO1 and COX2 expression levels in colorectal cancer (CRC) patients with liver oligometastases could be independent predictors of overall survival (OS) and progression-free survival (PFS). The purpose of this study was to investigate the correlation of IDO1 and COX2 expression levels with OS and PFS in CRC patients with liver oligometastases. Methods: The expression levels of IDO1 and COX2 were assessed by immunohistochemistry in 107 specimens from patients with liver oligometastases. The correlation between the expression of IDO1 and COX2 and the clinicopathological parameters and OS/PFS in patients was examined. Results: The expression level of IDO1/COX2 was significantly correlated with age and was not associated with gender, BMI, T stage, N stage, primary tumor size, liver metastasis size, CEA, CA19-9, CD3 TILs or CD8 TILs. In univariate analysis, we found that IDO1/COX2 expression, CEA and N stage all yielded significantly poor OS and PFS outcomes. In our multivariate Cox model, IDO1/COX2 coexpression, CEA and N stage were found to be significantly correlated with OS; IDO1/COX2 coexpression and CEA were significantly correlated with PFS. Conclusions: IDO1/COX2 coexpression plays a pivotal role and may act as a potential prognostic biomarker for survival in CRC patients with liver oligometastases. |
| first_indexed | 2024-03-11T06:19:06Z |
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| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T06:19:06Z |
| publishDate | 2023-03-01 |
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| series | Journal of Personalized Medicine |
| spelling | doaj.art-59d1ab82063446e2b84ebbb17376665b2023-11-17T12:03:09ZengMDPI AGJournal of Personalized Medicine2075-44262023-03-0113349610.3390/jpm13030496IDO1/COX2 Expression Is Associated with Poor Prognosis in Colorectal Cancer Liver OligometastasesMiaoqing Wu0Xiaoliang Wu1Xing Wang2Xiangchan Hong3Yifan Liu4Guangzhao Lv5Cong Li6Zhizhong Pan7Rongxin Zhang8Gong Chen9Department of Colorectal Surgery, Cancer Centre, Sun Yat-sen University, Guangzhou 510060, ChinaDepartment of Oncology, Shenzhen Hospital of Southern Medical University, Shenzhen 518000, ChinaFirst Affiliated Hospital of Jiangxi Medical College, Nanchang 330000, ChinaDepartment of Oncology, Shenzhen Hospital of Southern Medical University, Shenzhen 518000, ChinaDepartment of Colorectal Surgery, Cancer Centre, Sun Yat-sen University, Guangzhou 510060, ChinaDepartment of Colorectal Surgery, Cancer Centre, Sun Yat-sen University, Guangzhou 510060, ChinaDepartment of Colorectal Surgery, Cancer Centre, Sun Yat-sen University, Guangzhou 510060, ChinaDepartment of Colorectal Surgery, Cancer Centre, Sun Yat-sen University, Guangzhou 510060, ChinaDepartment of Colorectal Surgery, Cancer Centre, Sun Yat-sen University, Guangzhou 510060, ChinaDepartment of Colorectal Surgery, Cancer Centre, Sun Yat-sen University, Guangzhou 510060, ChinaBackground: IDO1 and COX2 have emerged as promising immunotherapy targets. It is unclear whether IDO1 and COX2 expression levels in colorectal cancer (CRC) patients with liver oligometastases could be independent predictors of overall survival (OS) and progression-free survival (PFS). The purpose of this study was to investigate the correlation of IDO1 and COX2 expression levels with OS and PFS in CRC patients with liver oligometastases. Methods: The expression levels of IDO1 and COX2 were assessed by immunohistochemistry in 107 specimens from patients with liver oligometastases. The correlation between the expression of IDO1 and COX2 and the clinicopathological parameters and OS/PFS in patients was examined. Results: The expression level of IDO1/COX2 was significantly correlated with age and was not associated with gender, BMI, T stage, N stage, primary tumor size, liver metastasis size, CEA, CA19-9, CD3 TILs or CD8 TILs. In univariate analysis, we found that IDO1/COX2 expression, CEA and N stage all yielded significantly poor OS and PFS outcomes. In our multivariate Cox model, IDO1/COX2 coexpression, CEA and N stage were found to be significantly correlated with OS; IDO1/COX2 coexpression and CEA were significantly correlated with PFS. Conclusions: IDO1/COX2 coexpression plays a pivotal role and may act as a potential prognostic biomarker for survival in CRC patients with liver oligometastases.https://www.mdpi.com/2075-4426/13/3/496colorectal canceroligometastasesIDO1COX2prognosis |
| spellingShingle | Miaoqing Wu Xiaoliang Wu Xing Wang Xiangchan Hong Yifan Liu Guangzhao Lv Cong Li Zhizhong Pan Rongxin Zhang Gong Chen IDO1/COX2 Expression Is Associated with Poor Prognosis in Colorectal Cancer Liver Oligometastases Journal of Personalized Medicine colorectal cancer oligometastases IDO1 COX2 prognosis |
| title | IDO1/COX2 Expression Is Associated with Poor Prognosis in Colorectal Cancer Liver Oligometastases |
| title_full | IDO1/COX2 Expression Is Associated with Poor Prognosis in Colorectal Cancer Liver Oligometastases |
| title_fullStr | IDO1/COX2 Expression Is Associated with Poor Prognosis in Colorectal Cancer Liver Oligometastases |
| title_full_unstemmed | IDO1/COX2 Expression Is Associated with Poor Prognosis in Colorectal Cancer Liver Oligometastases |
| title_short | IDO1/COX2 Expression Is Associated with Poor Prognosis in Colorectal Cancer Liver Oligometastases |
| title_sort | ido1 cox2 expression is associated with poor prognosis in colorectal cancer liver oligometastases |
| topic | colorectal cancer oligometastases IDO1 COX2 prognosis |
| url | https://www.mdpi.com/2075-4426/13/3/496 |
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