Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape

Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape

Abstract Hypoxia, a common feature of the tumor microenvironment in various types of cancers, weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby reducing tumoral immunogenicity. Studies have demonstrated that hypoxia and hypoxia-inducible factors (HIFs) 1 and 2 a...

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Bibliographic Details
Main Authors: Qinghua Wu, Li You, Eugenie Nepovimova, Zbynek Heger, Wenda Wu, Kamil Kuca, Vojtech Adam
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Hematology & Oncology
Subjects:
Hypoxia
Hypoxia-inducible factors
Tumor disease
Immunotherapy
Personalized medicine
Online Access:https://doi.org/10.1186/s13045-022-01292-6

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