Potential Thai medicinal plants for neurodegenerative diseases: A review focusing on the anti-glutamate toxicity effect
Neurodegenerative diseases (NDD) are a range of debilitating conditions of the brain involving progressive loss of neurons, many of which are still currently incurable despite enormous efforts on drug discovery and development in the past decade. As NDD is closely linked to old age, the rapid worldw...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-05-01
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| Series: | Journal of Traditional and Complementary Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S222541101931301X |
| _version_ | 1818292390795935744 |
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| author | Anchalee Prasansuklab James M. Brimson Tewin Tencomnao |
| author_facet | Anchalee Prasansuklab James M. Brimson Tewin Tencomnao |
| author_sort | Anchalee Prasansuklab |
| collection | DOAJ |
| description | Neurodegenerative diseases (NDD) are a range of debilitating conditions of the brain involving progressive loss of neurons, many of which are still currently incurable despite enormous efforts on drug discovery and development in the past decade. As NDD is closely linked to old age, the rapid worldwide growth in the aging population contributes to an increasing number of people with one of these incurable diseases and therefore it is considered a significant global health issue. There is an urgent need for novel effective treatments for NDD, and many new research strategies are centered on traditional medicine as an alternative or complementary solution. Several previous findings have suggested that glutamate toxicity drives neurodegeneration in many NDD, and the medicinal plants with anti-glutamate toxicity properties can be potentially used for their treatment. In order to obtain data relating to natural products against glutamate toxicity, six candidate plant species of Thailand were identified. Studies utilizing these herbs were searched for using the herb name (Latin and common names) along with the term “glutamate” in the following databases across all available years: PubMed, Scopus, and Google Scholar. This review emphasizes the importance of glutamate toxicity in NDD and summarizes individual plants and their active constituents with the mechanism of action against glutamate toxicity-mediated neuronal cell death that could be a promising resource for future NDD therapy. Taxonomy (classification by evise): Alzheimer’s disease, Neurodegenerative diseases, Cell culture, Molecular Biology, Traditional herbal medicine, Oxidative stress, Glutamate neurotransmitter. |
| first_indexed | 2024-12-13T02:59:12Z |
| format | Article |
| id | doaj.art-59d73bb16a634c27b36705ade2b366c9 |
| institution | Directory Open Access Journal |
| issn | 2225-4110 |
| language | English |
| last_indexed | 2024-12-13T02:59:12Z |
| publishDate | 2020-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Traditional and Complementary Medicine |
| spelling | doaj.art-59d73bb16a634c27b36705ade2b366c92022-12-22T00:01:53ZengElsevierJournal of Traditional and Complementary Medicine2225-41102020-05-01103301308Potential Thai medicinal plants for neurodegenerative diseases: A review focusing on the anti-glutamate toxicity effectAnchalee Prasansuklab0James M. Brimson1Tewin Tencomnao2College of Public Health Sciences, Chulalongkorn University, Bangkok, 10330, ThailandAge-Related Inflammation and Degeneration Research Unit, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, ThailandAge-Related Inflammation and Degeneration Research Unit, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand; Corresponding author.Neurodegenerative diseases (NDD) are a range of debilitating conditions of the brain involving progressive loss of neurons, many of which are still currently incurable despite enormous efforts on drug discovery and development in the past decade. As NDD is closely linked to old age, the rapid worldwide growth in the aging population contributes to an increasing number of people with one of these incurable diseases and therefore it is considered a significant global health issue. There is an urgent need for novel effective treatments for NDD, and many new research strategies are centered on traditional medicine as an alternative or complementary solution. Several previous findings have suggested that glutamate toxicity drives neurodegeneration in many NDD, and the medicinal plants with anti-glutamate toxicity properties can be potentially used for their treatment. In order to obtain data relating to natural products against glutamate toxicity, six candidate plant species of Thailand were identified. Studies utilizing these herbs were searched for using the herb name (Latin and common names) along with the term “glutamate” in the following databases across all available years: PubMed, Scopus, and Google Scholar. This review emphasizes the importance of glutamate toxicity in NDD and summarizes individual plants and their active constituents with the mechanism of action against glutamate toxicity-mediated neuronal cell death that could be a promising resource for future NDD therapy. Taxonomy (classification by evise): Alzheimer’s disease, Neurodegenerative diseases, Cell culture, Molecular Biology, Traditional herbal medicine, Oxidative stress, Glutamate neurotransmitter.http://www.sciencedirect.com/science/article/pii/S222541101931301XGlutamateNeuroprotectiveNeurotoxicityAlzheimer’s diseaseOxidative stressPlant extract |
| spellingShingle | Anchalee Prasansuklab James M. Brimson Tewin Tencomnao Potential Thai medicinal plants for neurodegenerative diseases: A review focusing on the anti-glutamate toxicity effect Journal of Traditional and Complementary Medicine Glutamate Neuroprotective Neurotoxicity Alzheimer’s disease Oxidative stress Plant extract |
| title | Potential Thai medicinal plants for neurodegenerative diseases: A review focusing on the anti-glutamate toxicity effect |
| title_full | Potential Thai medicinal plants for neurodegenerative diseases: A review focusing on the anti-glutamate toxicity effect |
| title_fullStr | Potential Thai medicinal plants for neurodegenerative diseases: A review focusing on the anti-glutamate toxicity effect |
| title_full_unstemmed | Potential Thai medicinal plants for neurodegenerative diseases: A review focusing on the anti-glutamate toxicity effect |
| title_short | Potential Thai medicinal plants for neurodegenerative diseases: A review focusing on the anti-glutamate toxicity effect |
| title_sort | potential thai medicinal plants for neurodegenerative diseases a review focusing on the anti glutamate toxicity effect |
| topic | Glutamate Neuroprotective Neurotoxicity Alzheimer’s disease Oxidative stress Plant extract |
| url | http://www.sciencedirect.com/science/article/pii/S222541101931301X |
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