BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth
Summary: Clinical evidence points to a function for B cell-activating factor (BAFF) in pregnancy. However, direct roles for BAFF-axis members in pregnancy have not been examined. Here, via utility of genetically modified mice, we report that BAFF promotes inflammatory responsiveness and increases su...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723003637 |
| _version_ | 1797850899061669888 |
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| author | Jessica R. Doll Maria E. Moreno-Fernandez Traci E. Stankiewicz Jennifer L. Wayland Adrienne Wilburn Benjamin Weinhaus Claire A. Chougnet Daniela Giordano Monica Cappelletti Pietro Presicce Suhas G. Kallapur Nathan Salomonis Tamara Tilburgs Senad Divanovic |
| author_facet | Jessica R. Doll Maria E. Moreno-Fernandez Traci E. Stankiewicz Jennifer L. Wayland Adrienne Wilburn Benjamin Weinhaus Claire A. Chougnet Daniela Giordano Monica Cappelletti Pietro Presicce Suhas G. Kallapur Nathan Salomonis Tamara Tilburgs Senad Divanovic |
| author_sort | Jessica R. Doll |
| collection | DOAJ |
| description | Summary: Clinical evidence points to a function for B cell-activating factor (BAFF) in pregnancy. However, direct roles for BAFF-axis members in pregnancy have not been examined. Here, via utility of genetically modified mice, we report that BAFF promotes inflammatory responsiveness and increases susceptibility to inflammation-induced preterm birth (PTB). In contrast, we show that the closely related A proliferation-inducing ligand (APRIL) decreases inflammatory responsiveness and susceptibility to PTB. Known BAFF-axis receptors serve a redundant function in signaling BAFF/APRIL presence in pregnancy. Treatment with anti-BAFF/APRIL monoclonal antibodies or BAFF/APRIL recombinant proteins is sufficient to manipulate susceptibility to PTB. Notably, macrophages at the maternal-fetal interface produce BAFF, while BAFF and APRIL presence divergently shape macrophage gene expression and inflammatory function. Overall, our findings demonstrate that BAFF and APRIL play divergent inflammatory roles in pregnancy and provide therapeutic targets for mitigating risk of inflammation-induced PTB. |
| first_indexed | 2024-04-09T19:09:07Z |
| format | Article |
| id | doaj.art-59d828a84fe34ca5847dca21b989426e |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-09T19:09:07Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-59d828a84fe34ca5847dca21b989426e2023-04-07T06:50:12ZengElsevierCell Reports2211-12472023-04-01424112352BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birthJessica R. Doll0Maria E. Moreno-Fernandez1Traci E. Stankiewicz2Jennifer L. Wayland3Adrienne Wilburn4Benjamin Weinhaus5Claire A. Chougnet6Daniela Giordano7Monica Cappelletti8Pietro Presicce9Suhas G. Kallapur10Nathan Salomonis11Tamara Tilburgs12Senad Divanovic13Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA; Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA; Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA; Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USAMedical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USADepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA; Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USADepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA; Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USADepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA; Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USADepartment of Medicine, Division of Rheumatology, University of Washington, Seattle, WA 98195, USADivision of Neonatology and Developmental Biology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USADivision of Neonatology and Developmental Biology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USADivision of Neonatology and Developmental Biology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USADepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA; Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA; Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA; Center for Inflammation and Tolerance, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA; Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA; Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA; Center for Inflammation and Tolerance, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA; Corresponding authorSummary: Clinical evidence points to a function for B cell-activating factor (BAFF) in pregnancy. However, direct roles for BAFF-axis members in pregnancy have not been examined. Here, via utility of genetically modified mice, we report that BAFF promotes inflammatory responsiveness and increases susceptibility to inflammation-induced preterm birth (PTB). In contrast, we show that the closely related A proliferation-inducing ligand (APRIL) decreases inflammatory responsiveness and susceptibility to PTB. Known BAFF-axis receptors serve a redundant function in signaling BAFF/APRIL presence in pregnancy. Treatment with anti-BAFF/APRIL monoclonal antibodies or BAFF/APRIL recombinant proteins is sufficient to manipulate susceptibility to PTB. Notably, macrophages at the maternal-fetal interface produce BAFF, while BAFF and APRIL presence divergently shape macrophage gene expression and inflammatory function. Overall, our findings demonstrate that BAFF and APRIL play divergent inflammatory roles in pregnancy and provide therapeutic targets for mitigating risk of inflammation-induced PTB.http://www.sciencedirect.com/science/article/pii/S2211124723003637CP: Immunology |
| spellingShingle | Jessica R. Doll Maria E. Moreno-Fernandez Traci E. Stankiewicz Jennifer L. Wayland Adrienne Wilburn Benjamin Weinhaus Claire A. Chougnet Daniela Giordano Monica Cappelletti Pietro Presicce Suhas G. Kallapur Nathan Salomonis Tamara Tilburgs Senad Divanovic BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth Cell Reports CP: Immunology |
| title | BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth |
| title_full | BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth |
| title_fullStr | BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth |
| title_full_unstemmed | BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth |
| title_short | BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth |
| title_sort | baff and april counterregulate susceptibility to inflammation induced preterm birth |
| topic | CP: Immunology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723003637 |
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