The CCL20-CCR6 Axis in Cancer Progression
Chemokines, which are basic proteins that exert their effects via G protein-coupled receptors and a subset of the cytokine family, are mediators deeply involved in leukocyte migration during an inflammatory reaction. Chemokine (C-C motif) ligand 20 (CCL20), also known as macrophage inflammatory prot...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/15/5186 |
| _version_ | 1797561645201883136 |
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| author | Suguru Kadomoto Kouji Izumi Atsushi Mizokami |
| author_facet | Suguru Kadomoto Kouji Izumi Atsushi Mizokami |
| author_sort | Suguru Kadomoto |
| collection | DOAJ |
| description | Chemokines, which are basic proteins that exert their effects via G protein-coupled receptors and a subset of the cytokine family, are mediators deeply involved in leukocyte migration during an inflammatory reaction. Chemokine (C-C motif) ligand 20 (CCL20), also known as macrophage inflammatory protein (MIP)-3α, liver activation regulated chemokine (LARC), and Exodus-1, is a small protein that is physiologically expressed in the liver, colon, and skin, is involved in tissue inflammation and homeostasis, and has a specific receptor <b>C-C</b> chemokine receptor 6 (CCR6). The CCL20-CCR6 axis has long been known to be involved in inflammatory and infectious diseases, such as rheumatoid arthritis and human immunodeficiency virus infections. Recently, however, reports have shown that the CCL20-CCR6 axis is associated with several cancers, including hepatocellular carcinoma, colorectal cancer, breast cancer, pancreatic cancer, cervical cancer, and kidney cancer. The CCL20-CCR6 axis promotes cancer progression directly by enhancing migration and proliferation of cancer cells and indirectly by remodeling the tumor microenvironment through immune cell control. The present article reviewed the role of the CCL20-CCR6 axis in cancer progression and its potential as a therapeutic target. |
| first_indexed | 2024-03-10T18:17:51Z |
| format | Article |
| id | doaj.art-59d8431609ea4fcca924a5159e5169fe |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:17:51Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-59d8431609ea4fcca924a5159e5169fe2023-11-20T07:33:29ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-012115518610.3390/ijms21155186The CCL20-CCR6 Axis in Cancer ProgressionSuguru Kadomoto0Kouji Izumi1Atsushi Mizokami2Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8641, Ishikawa, JapanDepartment of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8641, Ishikawa, JapanDepartment of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8641, Ishikawa, JapanChemokines, which are basic proteins that exert their effects via G protein-coupled receptors and a subset of the cytokine family, are mediators deeply involved in leukocyte migration during an inflammatory reaction. Chemokine (C-C motif) ligand 20 (CCL20), also known as macrophage inflammatory protein (MIP)-3α, liver activation regulated chemokine (LARC), and Exodus-1, is a small protein that is physiologically expressed in the liver, colon, and skin, is involved in tissue inflammation and homeostasis, and has a specific receptor <b>C-C</b> chemokine receptor 6 (CCR6). The CCL20-CCR6 axis has long been known to be involved in inflammatory and infectious diseases, such as rheumatoid arthritis and human immunodeficiency virus infections. Recently, however, reports have shown that the CCL20-CCR6 axis is associated with several cancers, including hepatocellular carcinoma, colorectal cancer, breast cancer, pancreatic cancer, cervical cancer, and kidney cancer. The CCL20-CCR6 axis promotes cancer progression directly by enhancing migration and proliferation of cancer cells and indirectly by remodeling the tumor microenvironment through immune cell control. The present article reviewed the role of the CCL20-CCR6 axis in cancer progression and its potential as a therapeutic target.https://www.mdpi.com/1422-0067/21/15/5186chemokinesCCL20-CCR6 axiscancer progression |
| spellingShingle | Suguru Kadomoto Kouji Izumi Atsushi Mizokami The CCL20-CCR6 Axis in Cancer Progression International Journal of Molecular Sciences chemokines CCL20-CCR6 axis cancer progression |
| title | The CCL20-CCR6 Axis in Cancer Progression |
| title_full | The CCL20-CCR6 Axis in Cancer Progression |
| title_fullStr | The CCL20-CCR6 Axis in Cancer Progression |
| title_full_unstemmed | The CCL20-CCR6 Axis in Cancer Progression |
| title_short | The CCL20-CCR6 Axis in Cancer Progression |
| title_sort | ccl20 ccr6 axis in cancer progression |
| topic | chemokines CCL20-CCR6 axis cancer progression |
| url | https://www.mdpi.com/1422-0067/21/15/5186 |
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