Serum copper decrease and cerebellar atrophy in patients with nitrous oxide-induced subacute combined degeneration: two cases report
Abstract Background Subacute combined degeneration (SCD) is a neurological complication commonly associated with vitamin B12 deficiency. It can result from nitrous oxide (N2O) abuse and cause neuropsychiatric symptoms. However, there has been no literature regarding alterations of serum copper and c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-021-02496-y |
| _version_ | 1818737696928956416 |
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| author | Jie Cao Lusen Ran Chenchen Liu Zhijun Li |
| author_facet | Jie Cao Lusen Ran Chenchen Liu Zhijun Li |
| author_sort | Jie Cao |
| collection | DOAJ |
| description | Abstract Background Subacute combined degeneration (SCD) is a neurological complication commonly associated with vitamin B12 deficiency. It can result from nitrous oxide (N2O) abuse and cause neuropsychiatric symptoms. However, there has been no literature regarding alterations of serum copper and cerebellum in SCD patients. Case presentation We reported two cases of young SCD patients with histories of N2O abuse. In these cases, elevated homocysteine, macrocytic anemia, spinal cord abnormalities, and peripheral nerve injuries were detected. In addition, decreased serum copper level and cerebellar atrophy were reported for the first time. The patients’ symptoms improved after withdrawal of N2O exposure and vitamin B12 supplements. Conclusion We reported two SCD cases with serum copper alteration and cerebellar atrophy after N2O abuse for the first time. These might be crucial complements to the diagnosis of SCD. |
| first_indexed | 2024-12-18T00:57:09Z |
| format | Article |
| id | doaj.art-59d917f62a3b485192fc81965f4aad30 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-18T00:57:09Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-59d917f62a3b485192fc81965f4aad302022-12-21T21:26:29ZengBMCBMC Neurology1471-23772021-12-012111610.1186/s12883-021-02496-ySerum copper decrease and cerebellar atrophy in patients with nitrous oxide-induced subacute combined degeneration: two cases reportJie Cao0Lusen Ran1Chenchen Liu2Zhijun Li3Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background Subacute combined degeneration (SCD) is a neurological complication commonly associated with vitamin B12 deficiency. It can result from nitrous oxide (N2O) abuse and cause neuropsychiatric symptoms. However, there has been no literature regarding alterations of serum copper and cerebellum in SCD patients. Case presentation We reported two cases of young SCD patients with histories of N2O abuse. In these cases, elevated homocysteine, macrocytic anemia, spinal cord abnormalities, and peripheral nerve injuries were detected. In addition, decreased serum copper level and cerebellar atrophy were reported for the first time. The patients’ symptoms improved after withdrawal of N2O exposure and vitamin B12 supplements. Conclusion We reported two SCD cases with serum copper alteration and cerebellar atrophy after N2O abuse for the first time. These might be crucial complements to the diagnosis of SCD.https://doi.org/10.1186/s12883-021-02496-yNitrous oxideSubacute combined degenerationSerum copperCerebellar atrophyCognitive decline |
| spellingShingle | Jie Cao Lusen Ran Chenchen Liu Zhijun Li Serum copper decrease and cerebellar atrophy in patients with nitrous oxide-induced subacute combined degeneration: two cases report BMC Neurology Nitrous oxide Subacute combined degeneration Serum copper Cerebellar atrophy Cognitive decline |
| title | Serum copper decrease and cerebellar atrophy in patients with nitrous oxide-induced subacute combined degeneration: two cases report |
| title_full | Serum copper decrease and cerebellar atrophy in patients with nitrous oxide-induced subacute combined degeneration: two cases report |
| title_fullStr | Serum copper decrease and cerebellar atrophy in patients with nitrous oxide-induced subacute combined degeneration: two cases report |
| title_full_unstemmed | Serum copper decrease and cerebellar atrophy in patients with nitrous oxide-induced subacute combined degeneration: two cases report |
| title_short | Serum copper decrease and cerebellar atrophy in patients with nitrous oxide-induced subacute combined degeneration: two cases report |
| title_sort | serum copper decrease and cerebellar atrophy in patients with nitrous oxide induced subacute combined degeneration two cases report |
| topic | Nitrous oxide Subacute combined degeneration Serum copper Cerebellar atrophy Cognitive decline |
| url | https://doi.org/10.1186/s12883-021-02496-y |
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