Socio demographic, clinical, and side effect profile of patients on clozapine in Kashmir, North India
Abstract Background Clozapine is an atypical second-generation antipsychotic belonging to the family of dibenzodiazepines. There is lack of literature on clozapine from this part of the world. So, our aim was to study the socio demographic, clinical and side effect profile of patients on clozapine i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-12-01
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| Series: | Middle East Current Psychiatry |
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| Online Access: | https://doi.org/10.1186/s43045-021-00163-z |
| _version_ | 1818969392013115392 |
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| author | Deeba Nazir Zaid Ahmad Wani Fahd Bukhari Shabir Ahmad Dar Yuman Kawoosa |
| author_facet | Deeba Nazir Zaid Ahmad Wani Fahd Bukhari Shabir Ahmad Dar Yuman Kawoosa |
| author_sort | Deeba Nazir |
| collection | DOAJ |
| description | Abstract Background Clozapine is an atypical second-generation antipsychotic belonging to the family of dibenzodiazepines. There is lack of literature on clozapine from this part of the world. So, our aim was to study the socio demographic, clinical and side effect profile of patients on clozapine in Kashmir. Results The mean age of the study group was 32.6 ± 8.9 years with majority being males (78.4%), unmarried (78.4%), unemployed (77.2%), and belonging to nuclear families (77.2%). Almost half of them resided in urban localities (51.1%) and studied upto middle school (55.7%). Around three- fourth (75%) of the patients had diagnosis of treatment-resistant schizophrenia. The mean dose of clozapine was 338.92 ± 158.11 mgs. Sedation (76.1%), hypersalivation (69.5%), constipation (46.6%), and weight gain (34.1%) were most common side effects noted in patients. 4.5% cases developed seizures while on clozapine. 2.3% patients developed agranulocytosis while 4.5% patients developed neutropenia on clozapine. The neutropenia was more pronounced in patients of schizophrenia with suicidal tendencies with doses of more than 400 mg. Conclusions We have used clozapine in a wide range of indications. Our patients seem to tolerate and respond to higher doses of clozapine and the prevalence of blood dyscrasias in our study sample was much higher than the rest of India. |
| first_indexed | 2024-12-20T14:19:51Z |
| format | Article |
| id | doaj.art-59d961afc7aa4941ad6aa172bc71e3ef |
| institution | Directory Open Access Journal |
| issn | 2090-5416 |
| language | English |
| last_indexed | 2024-12-20T14:19:51Z |
| publishDate | 2021-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Middle East Current Psychiatry |
| spelling | doaj.art-59d961afc7aa4941ad6aa172bc71e3ef2022-12-21T19:37:57ZengSpringerOpenMiddle East Current Psychiatry2090-54162021-12-012811910.1186/s43045-021-00163-zSocio demographic, clinical, and side effect profile of patients on clozapine in Kashmir, North IndiaDeeba Nazir0Zaid Ahmad Wani1Fahd Bukhari2Shabir Ahmad Dar3Yuman Kawoosa4Department of Psychiatry, Institute of Mental Health and Neurosciences Kashmir, Government Medical CollegeDepartment of Psychiatry, Institute of Mental Health and Neurosciences Kashmir, Government Medical CollegeAl Rafa Group of HospitalsDepartment of Psychiatry, Institute of Mental Health and Neurosciences Kashmir, Government Medical CollegeDepartment of Psychiatry, Institute of Mental Health and Neurosciences Kashmir, Government Medical CollegeAbstract Background Clozapine is an atypical second-generation antipsychotic belonging to the family of dibenzodiazepines. There is lack of literature on clozapine from this part of the world. So, our aim was to study the socio demographic, clinical and side effect profile of patients on clozapine in Kashmir. Results The mean age of the study group was 32.6 ± 8.9 years with majority being males (78.4%), unmarried (78.4%), unemployed (77.2%), and belonging to nuclear families (77.2%). Almost half of them resided in urban localities (51.1%) and studied upto middle school (55.7%). Around three- fourth (75%) of the patients had diagnosis of treatment-resistant schizophrenia. The mean dose of clozapine was 338.92 ± 158.11 mgs. Sedation (76.1%), hypersalivation (69.5%), constipation (46.6%), and weight gain (34.1%) were most common side effects noted in patients. 4.5% cases developed seizures while on clozapine. 2.3% patients developed agranulocytosis while 4.5% patients developed neutropenia on clozapine. The neutropenia was more pronounced in patients of schizophrenia with suicidal tendencies with doses of more than 400 mg. Conclusions We have used clozapine in a wide range of indications. Our patients seem to tolerate and respond to higher doses of clozapine and the prevalence of blood dyscrasias in our study sample was much higher than the rest of India.https://doi.org/10.1186/s43045-021-00163-zClozapineSociodemographicClinicalSide effectsKashmir |
| spellingShingle | Deeba Nazir Zaid Ahmad Wani Fahd Bukhari Shabir Ahmad Dar Yuman Kawoosa Socio demographic, clinical, and side effect profile of patients on clozapine in Kashmir, North India Middle East Current Psychiatry Clozapine Sociodemographic Clinical Side effects Kashmir |
| title | Socio demographic, clinical, and side effect profile of patients on clozapine in Kashmir, North India |
| title_full | Socio demographic, clinical, and side effect profile of patients on clozapine in Kashmir, North India |
| title_fullStr | Socio demographic, clinical, and side effect profile of patients on clozapine in Kashmir, North India |
| title_full_unstemmed | Socio demographic, clinical, and side effect profile of patients on clozapine in Kashmir, North India |
| title_short | Socio demographic, clinical, and side effect profile of patients on clozapine in Kashmir, North India |
| title_sort | socio demographic clinical and side effect profile of patients on clozapine in kashmir north india |
| topic | Clozapine Sociodemographic Clinical Side effects Kashmir |
| url | https://doi.org/10.1186/s43045-021-00163-z |
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