Hepatitis B infection is causally associated with extrahepatic cancers: A Mendelian randomization study
Summary: Background: Evidence from observational studies suggests that chronic hepatitis B virus (HBV) infection is associated with extrahepatic cancers. However, the causal association between chronic HBV infection and extrahepatic cancers remains to be determined. Methods: We performed two-sample...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | EBioMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396422001876 |
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| author | Abram Bunya Kamiza Segun Fatumo Mwiza Gideon Singini Chih-Ching Yeh Tinashe Chikowore |
| author_facet | Abram Bunya Kamiza Segun Fatumo Mwiza Gideon Singini Chih-Ching Yeh Tinashe Chikowore |
| author_sort | Abram Bunya Kamiza |
| collection | DOAJ |
| description | Summary: Background: Evidence from observational studies suggests that chronic hepatitis B virus (HBV) infection is associated with extrahepatic cancers. However, the causal association between chronic HBV infection and extrahepatic cancers remains to be determined. Methods: We performed two-sample Mendelian randomization (MR) to investigate whether chronic HBV infection is causally associated with extrahepatic cancers. We identified four independent genetic variants strongly associated (P-value < 5 × 10−8) with the exposure, chronic HBV infection in 1371 cases and 2938 controls of East Asian ancestry in Korea, which were used as instrumental variables. Genome-wide association summary level data for outcome variables, that included cancer of the biliary tract, cervix, colorectum, endometrium, esophagus, gastric, hepatocellular carcinoma, lung, ovary and pancreas were obtained from Biobank Japan. Findings: Using the multivariable inverse variance weighted method, we found genetic liability to chronic HBV infection causally associated with extrahepatic cancers including cervical cancer (odds ratio [OR] = 1.57, 95% confidence interval [CI] = 1.29–1.91, P-value = 0.0001) and gastric cancer (OR = 1.12, 95% CI = 1.05–1.19, P-value = 0.0001). Moreover, chronic HBV infection (OR = 1.20, 95% CI = 1.07–1.34, P-value = 0.0021) was causally associated with hepatocellular carcinoma, supporting a well-established association between chronic HBV infection and hepatocellular carcinoma. Interpretation: : Our MR analysis revealed that chronic HBV infection is causally associated with extrahepatic cancers including cervical and gastric cancers. Funding: None. |
| first_indexed | 2024-12-10T03:44:11Z |
| format | Article |
| id | doaj.art-59db7df870384fd0b4c0a4a8e051edb9 |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-12-10T03:44:11Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-59db7df870384fd0b4c0a4a8e051edb92022-12-22T02:03:27ZengElsevierEBioMedicine2352-39642022-05-0179104003Hepatitis B infection is causally associated with extrahepatic cancers: A Mendelian randomization studyAbram Bunya Kamiza0Segun Fatumo1Mwiza Gideon Singini2Chih-Ching Yeh3Tinashe Chikowore4Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, 9 Jubilee Road, Johannesburg, South Africa; Corresponding author.The African Computational Genomics (TACG) Research Group, MRC/UVRI and LSHTM, Entebbe, Uganda; Department of Non-Communicable Disease Epidemiology (NCDE), London School of Hygiene and Tropical Medicine, London, United KingdomNational Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa; School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaSchool of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan; Department of Public Health, China Medical University, Taichung, Taiwan; Cancer Centre, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Master Program in Applied Epidemiology, College of Public Health, Taipei Medical University, Taipei, TaiwanSydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, 9 Jubilee Road, Johannesburg, South Africa; MRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaSummary: Background: Evidence from observational studies suggests that chronic hepatitis B virus (HBV) infection is associated with extrahepatic cancers. However, the causal association between chronic HBV infection and extrahepatic cancers remains to be determined. Methods: We performed two-sample Mendelian randomization (MR) to investigate whether chronic HBV infection is causally associated with extrahepatic cancers. We identified four independent genetic variants strongly associated (P-value < 5 × 10−8) with the exposure, chronic HBV infection in 1371 cases and 2938 controls of East Asian ancestry in Korea, which were used as instrumental variables. Genome-wide association summary level data for outcome variables, that included cancer of the biliary tract, cervix, colorectum, endometrium, esophagus, gastric, hepatocellular carcinoma, lung, ovary and pancreas were obtained from Biobank Japan. Findings: Using the multivariable inverse variance weighted method, we found genetic liability to chronic HBV infection causally associated with extrahepatic cancers including cervical cancer (odds ratio [OR] = 1.57, 95% confidence interval [CI] = 1.29–1.91, P-value = 0.0001) and gastric cancer (OR = 1.12, 95% CI = 1.05–1.19, P-value = 0.0001). Moreover, chronic HBV infection (OR = 1.20, 95% CI = 1.07–1.34, P-value = 0.0021) was causally associated with hepatocellular carcinoma, supporting a well-established association between chronic HBV infection and hepatocellular carcinoma. Interpretation: : Our MR analysis revealed that chronic HBV infection is causally associated with extrahepatic cancers including cervical and gastric cancers. Funding: None.http://www.sciencedirect.com/science/article/pii/S2352396422001876HBVCancerMendelian randomizationGeneticsSNPs |
| spellingShingle | Abram Bunya Kamiza Segun Fatumo Mwiza Gideon Singini Chih-Ching Yeh Tinashe Chikowore Hepatitis B infection is causally associated with extrahepatic cancers: A Mendelian randomization study EBioMedicine HBV Cancer Mendelian randomization Genetics SNPs |
| title | Hepatitis B infection is causally associated with extrahepatic cancers: A Mendelian randomization study |
| title_full | Hepatitis B infection is causally associated with extrahepatic cancers: A Mendelian randomization study |
| title_fullStr | Hepatitis B infection is causally associated with extrahepatic cancers: A Mendelian randomization study |
| title_full_unstemmed | Hepatitis B infection is causally associated with extrahepatic cancers: A Mendelian randomization study |
| title_short | Hepatitis B infection is causally associated with extrahepatic cancers: A Mendelian randomization study |
| title_sort | hepatitis b infection is causally associated with extrahepatic cancers a mendelian randomization study |
| topic | HBV Cancer Mendelian randomization Genetics SNPs |
| url | http://www.sciencedirect.com/science/article/pii/S2352396422001876 |
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