Effective engineering of a ketoreductase for the biocatalytic synthesis of an ipatasertib precursor

Effective engineering of a ketoreductase for the biocatalytic synthesis of an ipatasertib precursor

Abstract Semi-rational enzyme engineering is a powerful method to develop industrial biocatalysts. Profiting from advances in molecular biology and bioinformatics, semi-rational approaches can effectively accelerate enzyme engineering campaigns. Here, we present the optimization of a ketoreductase f...

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Bibliographic Details
Main Authors: Sumire Honda Malca, Nadine Duss, Jasmin Meierhofer, David Patsch, Michael Niklaus, Stefanie Reiter, Steven Paul Hanlon, Dennis Wetzl, Bernd Kuhn, Hans Iding, Rebecca Buller
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-024-01130-5

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