Enhanced Liver Fibrosis Score as a Biomarker for Vascular Damage Assessment in Patients with Takayasu Arteritis—A Pilot Study
Takayasu Arteritis (TA) is characterized by granulomatous panarteritis, vessel wall fibrosis, and irreversible vascular impairment. The aim of this study is to explore the usefulness of the Enhanced Liver Fibrosis score (ELF), procollagen-III aminoterminal propeptide (PIIINP), tissue inhibitor of ma...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/8/12/187 |
| _version_ | 1827671860155777024 |
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| author | Maja Stojanovic Sanvila Raskovic Vladimir Milivojevic Rada Miskovic Ivan Soldatovic Sanja Stankovic Ivan Rankovic Marija Stankovic Stanojevic Sanja Dragasevic Miodrag Krstic Andreas P. Diamantopoulos |
| author_facet | Maja Stojanovic Sanvila Raskovic Vladimir Milivojevic Rada Miskovic Ivan Soldatovic Sanja Stankovic Ivan Rankovic Marija Stankovic Stanojevic Sanja Dragasevic Miodrag Krstic Andreas P. Diamantopoulos |
| author_sort | Maja Stojanovic |
| collection | DOAJ |
| description | Takayasu Arteritis (TA) is characterized by granulomatous panarteritis, vessel wall fibrosis, and irreversible vascular impairment. The aim of this study is to explore the usefulness of the Enhanced Liver Fibrosis score (ELF), procollagen-III aminoterminal propeptide (PIIINP), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), and hyaluronic acid (HA) in assessing vascular damage in TA patients. ELF, PIIINP, TIMP-1, and HA were measured in 24 TA patients, and the results were correlated with the clinical damage indexes (VDI and TADS), an imaging damage score (CARDS), and disease activity scores (NIH and ITAS2010). A mean ELF score 8.42 (±1.12) and values higher than 7.7 (cut-off for liver fibrosis) in 21/24 (87.5%) of patients were detected. The VDI and TADS correlated significantly to ELF (<i>p</i> < 0.01). Additionally, a strong association across ELF and CARDS (<i>p</i> < 0.0001), PIIINP and CARDS (<i>p</i> < 0.001), and HA and CARDS (<i>p</i> < 0.001) was observed. No correlations of the tested biomarkers with inflammatory parameters, NIH, and ITAS2010 scores were found. To our knowledge, this is the first study that suggests the association of the serum biomarkers PIIINP, HA, and ELF score with damage but not with disease activity in TA patients. The ELF score and PIIINP may be useful biomarkers reflecting an ongoing fibrotic process and quantifying vascular damage. |
| first_indexed | 2024-03-10T03:51:38Z |
| format | Article |
| id | doaj.art-59deb91572524ae587b87cfdb05b84d6 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-10T03:51:38Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-59deb91572524ae587b87cfdb05b84d62023-11-23T08:55:08ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252021-12-0181218710.3390/jcdd8120187Enhanced Liver Fibrosis Score as a Biomarker for Vascular Damage Assessment in Patients with Takayasu Arteritis—A Pilot StudyMaja Stojanovic0Sanvila Raskovic1Vladimir Milivojevic2Rada Miskovic3Ivan Soldatovic4Sanja Stankovic5Ivan Rankovic6Marija Stankovic Stanojevic7Sanja Dragasevic8Miodrag Krstic9Andreas P. Diamantopoulos10Clinic for Allergy and Immunology, University Clinical Center of Serbia, Koste Todorovica 2, 11000 Belgrade, SerbiaClinic for Allergy and Immunology, University Clinical Center of Serbia, Koste Todorovica 2, 11000 Belgrade, SerbiaFaculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaClinic for Allergy and Immunology, University Clinical Center of Serbia, Koste Todorovica 2, 11000 Belgrade, SerbiaInstitute of Medical Statistics and Informatic, Faculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaCenter for Medical Biochemistry, University Clinical Center of Serbia, 11000 Belgrade, SerbiaFaculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaDepartment of Pathophysiology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaFaculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaFaculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaDepartment of Rheumatology, Akershus University Hospital, 1478 Lørenskog, NorwayTakayasu Arteritis (TA) is characterized by granulomatous panarteritis, vessel wall fibrosis, and irreversible vascular impairment. The aim of this study is to explore the usefulness of the Enhanced Liver Fibrosis score (ELF), procollagen-III aminoterminal propeptide (PIIINP), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), and hyaluronic acid (HA) in assessing vascular damage in TA patients. ELF, PIIINP, TIMP-1, and HA were measured in 24 TA patients, and the results were correlated with the clinical damage indexes (VDI and TADS), an imaging damage score (CARDS), and disease activity scores (NIH and ITAS2010). A mean ELF score 8.42 (±1.12) and values higher than 7.7 (cut-off for liver fibrosis) in 21/24 (87.5%) of patients were detected. The VDI and TADS correlated significantly to ELF (<i>p</i> < 0.01). Additionally, a strong association across ELF and CARDS (<i>p</i> < 0.0001), PIIINP and CARDS (<i>p</i> < 0.001), and HA and CARDS (<i>p</i> < 0.001) was observed. No correlations of the tested biomarkers with inflammatory parameters, NIH, and ITAS2010 scores were found. To our knowledge, this is the first study that suggests the association of the serum biomarkers PIIINP, HA, and ELF score with damage but not with disease activity in TA patients. The ELF score and PIIINP may be useful biomarkers reflecting an ongoing fibrotic process and quantifying vascular damage.https://www.mdpi.com/2308-3425/8/12/187Takayasu Arteritisvasculitisvascular damagebiomarkersELF |
| spellingShingle | Maja Stojanovic Sanvila Raskovic Vladimir Milivojevic Rada Miskovic Ivan Soldatovic Sanja Stankovic Ivan Rankovic Marija Stankovic Stanojevic Sanja Dragasevic Miodrag Krstic Andreas P. Diamantopoulos Enhanced Liver Fibrosis Score as a Biomarker for Vascular Damage Assessment in Patients with Takayasu Arteritis—A Pilot Study Journal of Cardiovascular Development and Disease Takayasu Arteritis vasculitis vascular damage biomarkers ELF |
| title | Enhanced Liver Fibrosis Score as a Biomarker for Vascular Damage Assessment in Patients with Takayasu Arteritis—A Pilot Study |
| title_full | Enhanced Liver Fibrosis Score as a Biomarker for Vascular Damage Assessment in Patients with Takayasu Arteritis—A Pilot Study |
| title_fullStr | Enhanced Liver Fibrosis Score as a Biomarker for Vascular Damage Assessment in Patients with Takayasu Arteritis—A Pilot Study |
| title_full_unstemmed | Enhanced Liver Fibrosis Score as a Biomarker for Vascular Damage Assessment in Patients with Takayasu Arteritis—A Pilot Study |
| title_short | Enhanced Liver Fibrosis Score as a Biomarker for Vascular Damage Assessment in Patients with Takayasu Arteritis—A Pilot Study |
| title_sort | enhanced liver fibrosis score as a biomarker for vascular damage assessment in patients with takayasu arteritis a pilot study |
| topic | Takayasu Arteritis vasculitis vascular damage biomarkers ELF |
| url | https://www.mdpi.com/2308-3425/8/12/187 |
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