Localized Therapeutic Approaches Based on Micro/Nanofibers for Cancer Treatment
Cancer remains one of the most challenging health problems worldwide, and localized therapeutic approaches based on micro/nanofibers have shown potential for its treatment. Micro/nanofibers offer several advantages as a drug delivery system, such as high surface area, tunable pore size, and sustaine...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/7/3053 |
| _version_ | 1797607408274505728 |
|---|---|
| author | Diana Alves Joana C. Araújo Raul Fangueiro Diana P. Ferreira |
| author_facet | Diana Alves Joana C. Araújo Raul Fangueiro Diana P. Ferreira |
| author_sort | Diana Alves |
| collection | DOAJ |
| description | Cancer remains one of the most challenging health problems worldwide, and localized therapeutic approaches based on micro/nanofibers have shown potential for its treatment. Micro/nanofibers offer several advantages as a drug delivery system, such as high surface area, tunable pore size, and sustained release properties, which can improve drug efficacy and reduce side effects. In addition, functionalization of these fibers with nanoparticles can enhance their targeting and therapeutic capabilities. Localized delivery of drugs and/or other therapeutic agents via micro/nanofibers can also help to overcome the limitations of systemic administration, such as poor bioavailability and off-target effects. Several studies have shown promising results in preclinical models of cancer, including inhibition of tumor growth and improved survival rates. However, more research is needed to overcome technical and regulatory challenges to bring these approaches to clinical use. Localized therapeutic approaches based on micro/nanofibers hold great promise for the future of cancer treatment, providing a targeted, effective, and minimally invasive alternative to traditional treatments. The main focus of this review is to explore the current treatments utilizing micro/nanofibers, as well as localized drug delivery systems that rely on fibrous structures to deliver and release drugs for the treatment of cancer in a specific area. |
| first_indexed | 2024-03-11T05:29:38Z |
| format | Article |
| id | doaj.art-59df674cf57f4703a1e74558eef5de94 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T05:29:38Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-59df674cf57f4703a1e74558eef5de942023-11-17T17:12:50ZengMDPI AGMolecules1420-30492023-03-01287305310.3390/molecules28073053Localized Therapeutic Approaches Based on Micro/Nanofibers for Cancer TreatmentDiana Alves0Joana C. Araújo1Raul Fangueiro2Diana P. Ferreira3Centre for Textile Science and Technology (2C2T), University of Minho, 4800 Guimarães, PortugalCentre for Textile Science and Technology (2C2T), University of Minho, 4800 Guimarães, PortugalCentre for Textile Science and Technology (2C2T), University of Minho, 4800 Guimarães, PortugalCentre for Textile Science and Technology (2C2T), University of Minho, 4800 Guimarães, PortugalCancer remains one of the most challenging health problems worldwide, and localized therapeutic approaches based on micro/nanofibers have shown potential for its treatment. Micro/nanofibers offer several advantages as a drug delivery system, such as high surface area, tunable pore size, and sustained release properties, which can improve drug efficacy and reduce side effects. In addition, functionalization of these fibers with nanoparticles can enhance their targeting and therapeutic capabilities. Localized delivery of drugs and/or other therapeutic agents via micro/nanofibers can also help to overcome the limitations of systemic administration, such as poor bioavailability and off-target effects. Several studies have shown promising results in preclinical models of cancer, including inhibition of tumor growth and improved survival rates. However, more research is needed to overcome technical and regulatory challenges to bring these approaches to clinical use. Localized therapeutic approaches based on micro/nanofibers hold great promise for the future of cancer treatment, providing a targeted, effective, and minimally invasive alternative to traditional treatments. The main focus of this review is to explore the current treatments utilizing micro/nanofibers, as well as localized drug delivery systems that rely on fibrous structures to deliver and release drugs for the treatment of cancer in a specific area.https://www.mdpi.com/1420-3049/28/7/3053cancerdrug delivery systemnanofibersnanoparticlestheragnostic |
| spellingShingle | Diana Alves Joana C. Araújo Raul Fangueiro Diana P. Ferreira Localized Therapeutic Approaches Based on Micro/Nanofibers for Cancer Treatment Molecules cancer drug delivery system nanofibers nanoparticles theragnostic |
| title | Localized Therapeutic Approaches Based on Micro/Nanofibers for Cancer Treatment |
| title_full | Localized Therapeutic Approaches Based on Micro/Nanofibers for Cancer Treatment |
| title_fullStr | Localized Therapeutic Approaches Based on Micro/Nanofibers for Cancer Treatment |
| title_full_unstemmed | Localized Therapeutic Approaches Based on Micro/Nanofibers for Cancer Treatment |
| title_short | Localized Therapeutic Approaches Based on Micro/Nanofibers for Cancer Treatment |
| title_sort | localized therapeutic approaches based on micro nanofibers for cancer treatment |
| topic | cancer drug delivery system nanofibers nanoparticles theragnostic |
| url | https://www.mdpi.com/1420-3049/28/7/3053 |
| work_keys_str_mv | AT dianaalves localizedtherapeuticapproachesbasedonmicronanofibersforcancertreatment AT joanacaraujo localizedtherapeuticapproachesbasedonmicronanofibersforcancertreatment AT raulfangueiro localizedtherapeuticapproachesbasedonmicronanofibersforcancertreatment AT dianapferreira localizedtherapeuticapproachesbasedonmicronanofibersforcancertreatment |