The effect of a single mega dose injection of vitamin D on serum adiponectin concentration at first gestational diabetes mellitus: A randomized controlled clinical trial
Summary: Background & aims: Vitamin D is being increasingly recognized for its important non-skeletal functions including endocrine actions. This study investigated if a single, large, intramuscular postpartum injection of vitamin D improve adiponectin levels among women with gestational di...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-10-01
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| Series: | Clinical Nutrition Experimental |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S235293932030018X |
| _version_ | 1828914226178031616 |
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| author | Mahdieh Hosseinzadeh Elham Razmpoosh Elham shareghfarid Elham Hosseinzadeh Hossein Hadinedoushan Maryam-Alsadat Salami Maryam Khosravi Maryam Amini Hassan Mozaffari-Khosravi |
| author_facet | Mahdieh Hosseinzadeh Elham Razmpoosh Elham shareghfarid Elham Hosseinzadeh Hossein Hadinedoushan Maryam-Alsadat Salami Maryam Khosravi Maryam Amini Hassan Mozaffari-Khosravi |
| author_sort | Mahdieh Hosseinzadeh |
| collection | DOAJ |
| description | Summary: Background & aims: Vitamin D is being increasingly recognized for its important non-skeletal functions including endocrine actions. This study investigated if a single, large, intramuscular postpartum injection of vitamin D improve adiponectin levels among women with gestational diabetes mellitus (GDM). Methods: A total of 45 pregnant women with GDM participated in this randomized clinical trial. They were randomly divided into intervention and control group. The intervention group received an intramuscular injection of 300,000 IU of vitamin D during 3–10 days after their child delivery, but controls did not. Serum 25-hydroxyvitamin D, fasting plasma glucose (FPG), hemoglobin A1c (HbA1c) and serum adiponectin were measured at baseline and after 3 months of intervention. Results: Serum 25 OH vitamin D increase significantly in the intervention but not in the control group from 24.25 to 62.10 (nmol/L) (p-value < 0.01). Comparison in within group showed that adiponectin level increased significantly only among intervention group after the vitamin D injection from 7.45 to 8.98 (ngr/dL) (P-value = 0.01), while between group comparisons showed no significant differences in adiponectin concentration after the intervention (P-value < 0.05). Between and within group comparisons reported no significant alterations in the levels of HbA1c and FPG , as well. Conclusions: The 300,000 IU single dose of intramuscular injection of vitamin D is regarded as an effective procedure to improve vitamin D status which significantly increased the adiponectin levels among mothers with gestational diabetes after delivery. |
| first_indexed | 2024-12-13T19:50:28Z |
| format | Article |
| id | doaj.art-59dfcbd726314bb38d955a032c94b567 |
| institution | Directory Open Access Journal |
| issn | 2352-9393 |
| language | English |
| last_indexed | 2024-12-13T19:50:28Z |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Nutrition Experimental |
| spelling | doaj.art-59dfcbd726314bb38d955a032c94b5672022-12-21T23:33:26ZengElsevierClinical Nutrition Experimental2352-93932020-10-01333948The effect of a single mega dose injection of vitamin D on serum adiponectin concentration at first gestational diabetes mellitus: A randomized controlled clinical trialMahdieh Hosseinzadeh0Elham Razmpoosh1 Elham shareghfarid2Elham Hosseinzadeh3Hossein Hadinedoushan4Maryam-Alsadat Salami5Maryam Khosravi6Maryam Amini7Hassan Mozaffari-Khosravi8Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Food Science, College of Agriculture, Islamic Azad University, Yazd, IranDepartment of Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Internal Medicine, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Public Health, North Khorasan University of Medical Sciences, Bojnurd, IranDepartment of Nutrition Research, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding author.Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Corresponding author. Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Summary: Background & aims: Vitamin D is being increasingly recognized for its important non-skeletal functions including endocrine actions. This study investigated if a single, large, intramuscular postpartum injection of vitamin D improve adiponectin levels among women with gestational diabetes mellitus (GDM). Methods: A total of 45 pregnant women with GDM participated in this randomized clinical trial. They were randomly divided into intervention and control group. The intervention group received an intramuscular injection of 300,000 IU of vitamin D during 3–10 days after their child delivery, but controls did not. Serum 25-hydroxyvitamin D, fasting plasma glucose (FPG), hemoglobin A1c (HbA1c) and serum adiponectin were measured at baseline and after 3 months of intervention. Results: Serum 25 OH vitamin D increase significantly in the intervention but not in the control group from 24.25 to 62.10 (nmol/L) (p-value < 0.01). Comparison in within group showed that adiponectin level increased significantly only among intervention group after the vitamin D injection from 7.45 to 8.98 (ngr/dL) (P-value = 0.01), while between group comparisons showed no significant differences in adiponectin concentration after the intervention (P-value < 0.05). Between and within group comparisons reported no significant alterations in the levels of HbA1c and FPG , as well. Conclusions: The 300,000 IU single dose of intramuscular injection of vitamin D is regarded as an effective procedure to improve vitamin D status which significantly increased the adiponectin levels among mothers with gestational diabetes after delivery.http://www.sciencedirect.com/science/article/pii/S235293932030018XVitamin DMegadoseAdiponectinGestational diabetes mellitusFasting plasma glucoseHbA1c |
| spellingShingle | Mahdieh Hosseinzadeh Elham Razmpoosh Elham shareghfarid Elham Hosseinzadeh Hossein Hadinedoushan Maryam-Alsadat Salami Maryam Khosravi Maryam Amini Hassan Mozaffari-Khosravi The effect of a single mega dose injection of vitamin D on serum adiponectin concentration at first gestational diabetes mellitus: A randomized controlled clinical trial Clinical Nutrition Experimental Vitamin D Megadose Adiponectin Gestational diabetes mellitus Fasting plasma glucose HbA1c |
| title | The effect of a single mega dose injection of vitamin D on serum adiponectin concentration at first gestational diabetes mellitus: A randomized controlled clinical trial |
| title_full | The effect of a single mega dose injection of vitamin D on serum adiponectin concentration at first gestational diabetes mellitus: A randomized controlled clinical trial |
| title_fullStr | The effect of a single mega dose injection of vitamin D on serum adiponectin concentration at first gestational diabetes mellitus: A randomized controlled clinical trial |
| title_full_unstemmed | The effect of a single mega dose injection of vitamin D on serum adiponectin concentration at first gestational diabetes mellitus: A randomized controlled clinical trial |
| title_short | The effect of a single mega dose injection of vitamin D on serum adiponectin concentration at first gestational diabetes mellitus: A randomized controlled clinical trial |
| title_sort | effect of a single mega dose injection of vitamin d on serum adiponectin concentration at first gestational diabetes mellitus a randomized controlled clinical trial |
| topic | Vitamin D Megadose Adiponectin Gestational diabetes mellitus Fasting plasma glucose HbA1c |
| url | http://www.sciencedirect.com/science/article/pii/S235293932030018X |
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